3.4.24.75: lysostaphin
This is an abbreviated version!
For detailed information about lysostaphin, go to the full flat file.
Word Map on EC 3.4.24.75
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3.4.24.75
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staphylococci
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methicillin-resistant
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vancomycin
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simulans
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bactericidal
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pentaglycine
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bacteriolytic
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methicillin
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epidermidis
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mastitis
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antistaphylococcal
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cross-bridge
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bacteriocins
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staphylolyticus
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medicine
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autolysins
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oxacillin
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endolysins
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interpeptide
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teichoic
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biovar
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intramammary
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coagulase-negative
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muropeptide
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teicoplanin
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methicillin-sensitive
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cowan
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micrococci
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murein
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haemolyticus
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coagulase
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daptomycin
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mutanolysine
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diagnostics
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pharmacology
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food industry
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analysis
- 3.4.24.75
-
staphylococci
-
methicillin-resistant
- vancomycin
- simulans
-
bactericidal
- pentaglycine
-
bacteriolytic
- methicillin
- epidermidis
- mastitis
-
antistaphylococcal
-
cross-bridge
-
bacteriocins
- staphylolyticus
- medicine
- autolysins
- oxacillin
- endolysins
-
interpeptide
-
teichoic
-
biovar
-
intramammary
-
coagulase-negative
-
muropeptide
- teicoplanin
-
methicillin-sensitive
-
cowan
-
micrococci
- murein
- haemolyticus
- coagulase
-
daptomycin
-
mutanolysine
- diagnostics
- pharmacology
- food industry
- analysis
Reaction
Hydrolysis of the -Gly-/-Gly- bond in the pentaglycine inter-peptide link joining staphylococcal cell wall peptidoglycans =
Synonyms
ALE-1, BSYX-L210, Glycyl-glycine endopeptidase, Glycylglycine endopeptidase, Lspn, Lss, Lst, LYS, lysostaphin, Lysostaphin endopeptidase, LytU, More, peptidoglycan endopeptidase, r-Lys, r-lysostaphin, sa0205, SH3b, Staphylococcus aureus-specific cell wall endopeptidase lysostaphin
ECTree
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Application
Application on EC 3.4.24.75 - lysostaphin
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medicine
pharmacology
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lysostaphin is useful for treatment for systemic Staphylococcus aureus infection in a mouse model
additional information
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antistaphylococcal agent in clinical laboratories
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application as effective antibiotic drug against infections with Staphylococcus aureus
medicine
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therapeutic agent for the treatment of Staphylococcus aureus infections
medicine
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lysostaphin is useful in treatment of neonatal Staphylococcus aureus infection, overview
medicine
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potential therapeutic agent against antibiotic-resistant Staphylococcus aureus infections
medicine
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lysostaphin can be used potentially as a topical disinfectant or decolonizing agent against methicillin-resistant Staphylococcus aureus infection on on human skin prior to operations. The combination is significantly more effective than treatment with ranalexin or lysostaphin alone, overview
medicine
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lysostaphin is an effective treatment as well as prophylaxis for Staphylococcus aureus biofilms on indwelling catheters
medicine
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lysostaphin, in combinantion with the antibiotic ranalexin, is effective against wound or systemic infections caused by meticillin-resistant Staphylococcus aureus. The combination is significantly more effective than treatment with ranalexin or lysostaphin alone. Ranalexin and lysostaphin can be incorporated in wound dressings for the prevention and treatment of topical Staphylococcus aureus infections
medicine
lysostaphin can be used in combination with clarithromycin for the eradication of Staphylococcus aureus biofilms with a minimal biofilm eradication concentration reduction of 9 and 6fold dilutions on meticillin-resistant S. aureus and meticillin-susceptible S. aureus, respectively
medicine
lysostaphin has potential for use as an antistaphylococcal agent for treatment of infections caused by antibiotic-resistant strains of Staphylococcus aureus
medicine
lysostaphin is an antistaphylococcal agent. The enzyme is efficacious in the treatment of bovine mastitis caused by staphylococci
medicine
lysostaphin-functionalized cellulose fibers show activity against Staphylococcus aureus in an in vitro skin model (HaCaT keratinocyte) with low toxicity toward keratinocytes, suggesting good biocompatibility for these materials as antimicrobial matrices in wound healing applications
medicine
lysostaphin exerts high levels of activity against antibiotic-resistant strains of Staphylococcus aureus
medicine
lysostaphin is a therapeutic agent for methicillin-resistant Staphylococcus aureus pneumonia
medicine
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a bone morphogenetic protein 2-loaded lysostaphin-delivering hydrogel simultaneously prevents Staphylococcus aureus infection and repairs nonhealing segmental bone defects in the murine radius
medicine
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enzyme-functionalized gold and silver nanoparticles are an antibacterial platform for combating methicillin-resistant Staphylococcus aureus bacterial infections
medicine
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the enzyme can be used in life-threatening infections, such as endocarditis to increase the early in vivo activity of the antibiotics, and to prevent the emergence of linezolid resistant mutants
medicine
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the enzyme is a potential antimicrobial agent for Staphylococcus aureus infections
medicine
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the enzyme is used against established staphylococcal biofilms as an alternative to bovine mastitis control
medicine
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the enzyme is a potential antimicrobial agent for Staphylococcus aureus infections
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