3.4.24.73: jararhagin

This is an abbreviated version!
For detailed information about jararhagin, go to the full flat file.

Reaction

Hydrolysis of -His10-/-Leu-, -Ala14-/-Leu-, -Tyr16-/-Leu-and -Phe24-/-Phe- bonds in insulin B chain =

Synonyms

haemolytic factor-2, hemorrhagic svMP, HF2, HF2-proteinase, Jar, Jar-C, jararafibrase 1, jararhagin, jararhagin-c, JF1, JG, More, PIII snake venom metalloprotease, PIII snake venom metalloproteinase, PIII SVMP, rCDJARA, snake venom metalloproteinase, snake venom metalloproteinase-disintegrin, soluble haemorrhagic snake venom metalloproteinase, SVMP

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.24 Metalloendopeptidases

                3.4.24.73 jararhagin

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Results	in table
1	AA Sequence
2	Application
1	CAS Registry Number
2	Cloned(Commentary)
1	Crystallization (Commentary)
3	General Information
15	Inhibitors
6	KM Value [mM]
8	Localization
11	Metals/Ions
18	Molecular Weight [Da]
30	Natural Substrates/ Products (Substrates)
31	Organism
4	pH Optimum
1	pH Range
2	pH Stability
2	pI Value
11	Purification (Commentary)
2	Reaction
1	Reaction Type
31	Reference
1	Renatured (Commentary)
23	Source Tissue
4	Specific Activity [micromol/min/mg]
79	Substrates and Products (Substrate)
7	Subunits
31	Synonyms
4	Temperature Optimum [°C]
1	Temperature Stability [°C]
3	Turnover Number [1/s]

Inhibitors

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Inhibitors on EC 3.4.24.73 - jararhagin

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INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

1,10-phenanthroline

4 entries

Alpha-macroglobulin

Bothrops jararaca

-

no effective inhibition

668820

-

alpha2-Macroglobulin

Bothrops jararaca

-

-

31489

-

BJ46a

Bothrops jararaca

-

SVMP inhibitor forming a monovalent complex with jararhagin thus inhibiting its hemorrhagic and catalytic activities

670962

-

DM 43

Bothrops jararaca

-

SVMP inhibitor isolated from the venom of Didelphis marsupialis forming stable complexes with jararhagin thus inhibiting its hemorrhagic, fibrinolytic and proteolytic activities

670962

-

DTT

Bothrops jararaca

-

-

668820

EDTA

3 entries

metalloproteinase inhibitor POL 647

Bothrops jararaca

-

-

649140

-

PO41

Bothrops jararaca

-

SVMP inhibitor isolated from the venom of Philander opossum forming stable complexes with jararhagin thus inhibiting its hemorrhagic, fibrinolytic and proteolytic activities

670962

-

additional information

Bothrops jararaca

-

no inhibition by alpha2-macroblobulin

670962

-

1,10-phenanthroline

Bothrops jararaca

-

-

668820

1,10-phenanthroline

Bothrops jararaca

-

10 mM, at 37°C

670959

1,10-phenanthroline

Bothrops jararaca

-

1 mM

670965

1,10-phenanthroline

Bothrops jararaca

P30431

-

753848

EDTA

Bothrops jararaca

-

0.5 nM

31485

EDTA

Bothrops jararaca

-

1 mM

667233

EDTA

Bothrops jararaca

-

-

668820