3.4.24.73: jararhagin
This is an abbreviated version!
For detailed information about jararhagin, go to the full flat file.
Word Map on EC 3.4.24.73
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3.4.24.73
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bothrops
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jararaca
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metalloproteinases
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disintegrin-like
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svmps
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cysteine-rich
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envenom
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disintegrins
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viper
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collagen-induced
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alpha2beta1
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snakebite
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antivenoms
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marsupialis
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atrolysin
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trigramin
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atrox
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reprolysin
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didelphis
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hemorrhagins
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medicine
- 3.4.24.73
- bothrops
- jararaca
- metalloproteinases
-
disintegrin-like
-
svmps
-
cysteine-rich
-
envenom
-
disintegrins
- viper
-
collagen-induced
- alpha2beta1
-
snakebite
- antivenoms
- marsupialis
- atrolysin
-
trigramin
- atrox
-
reprolysin
-
didelphis
-
hemorrhagins
- medicine
Reaction
Hydrolysis of -His10-/-Leu-, -Ala14-/-Leu-, -Tyr16-/-Leu-and -Phe24-/-Phe- bonds in insulin B chain =
Synonyms
haemolytic factor-2, hemorrhagic svMP, HF2, HF2-proteinase, Jar, Jar-C, jararafibrase 1, jararhagin, jararhagin-c, JF1, JG, More, PIII snake venom metalloprotease, PIII snake venom metalloproteinase, PIII SVMP, rCDJARA, snake venom metalloproteinase, snake venom metalloproteinase-disintegrin, soluble haemorrhagic snake venom metalloproteinase, SVMP
ECTree
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General Information
General Information on EC 3.4.24.73 - jararhagin
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physiological function
additional information
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jararhagin toxin binding to collagen appears to be sufficient to inhibit collagen-induced platelet aggregation in the human host
jararhagin 0.03 mg/ml upregulated genes TP53, CDKN1A, CDKN2A, CASP3, CASP5, CASP6, CASP8, and E-CDH in SKMel-28, and genes ITGB6, ITGB7, CASP3, TP53, and CDKN1B in mouse fibroblasts
physiological function
jararhagin induces strong hemorrhage accompanied by hydrolysis of collagen fibers in the hypodermis and a marked degradation of type IV collagen at the vascular basement membrane. Toxin accumulation near blood vessels leads to enhanced catalysis of basement membrane components, resulting in the strong hemorrhagic activity of jararhagin