3.4.24.72: fibrolase

This is an abbreviated version!
For detailed information about fibrolase, go to the full flat file.

Reaction

Hydrolysis of -Ala14-/-Leu- in insulin B chain and -Lys413-/-Leu- in Aalpha-chain of fibrinogen =

Synonyms

3-203-fibrolase[3-serine], AfeE, Agkistrodon contortrix contortrix metalloproteinase, ALF, Alfimeprase, brevilysin L6, brevithrombolase, broad bean-fibrinolytic enzyme, CFR15-protease, fibrinolytic enzyme, fibrinolytic protease, Fibrinolytic proteinase, FIIa, neuwiedase, Non-hemorrhagic fibrinolytic metalloproteinase, plasmin, Proteinase, Agkistrodon contortrix contortrix venom metallo-, snake venom fibrinolytic enzyme, starase, UFEIII, VlF, wulfase

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.24 Metalloendopeptidases

                3.4.24.72 fibrolase

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Results	in table
12	Activating Compound
6	AA Sequence
13	Application
1	CAS Registry Number
6	Cloned(Commentary)
1	Crystallization (Commentary)
120	Disease/ Diagnostics
5	Expression
2	General Information
1	General Stability
1	IC50 Value
183	Inhibitors
1	Ki Value [mM]
33	KM Value [mM]
6	Localization
55	Metals/Ions
29	Molecular Weight [Da]
39	Natural Substrates/ Products (Substrates)
61	Organism
18	pH Optimum
11	pH Range
12	pH Stability
9	pI Value
3	Posttranslational Modification
1	Protein Variants
26	Purification (Commentary)
1	Reaction
1	Reaction Type
61	Reference
1	Renatured (Commentary)
27	Source Tissue
10	Specific Activity [micromol/min/mg]
4	Storage Stability
214	Substrates and Products (Substrate)
36	Subunits
62	Synonyms
20	Temperature Optimum [°C]
8	Temperature Range [°C]
13	Temperature Stability [°C]
30	Turnover Number [1/s]

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TURNOVER NUMBER [1/s]

SUBSTRATE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

6.03

Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg

Agkistrodon contortrix

-

-

668337, 670960

5

His-Thr-Glu-Ala-Leu-Val-Thr-Ser

Agkistrodon contortrix

-

-

668337, 670960

1.97

His-Thr-Glu-Arg-Leu-Val-Thr-Ser

Agkistrodon contortrix

-

-

668337, 670960

65.7

His-Thr-Glu-Asn-Leu-Val-Thr-Ser

Agkistrodon contortrix

-

-

668337, 670960

0.46

His-Thr-Glu-Glu-Leu-Val-Thr-Ser

Agkistrodon contortrix

-

-

668337, 670960

5.19

His-Thr-Glu-His-Leu-Val-Thr-Ser

Agkistrodon contortrix

-

-

668337, 670960

0.16

His-Thr-Glu-Leu-Leu-Val-Thr-Ser

Agkistrodon contortrix

-

-

668337, 670960

2.23

His-Thr-Glu-Lys-Leu-Val-Thr-Ser

Agkistrodon contortrix

-

-

668337, 670960

0.2

His-Thr-Glu-Lys-Phe-Val-Thr-Ser

Agkistrodon contortrix

-

-

668337, 670960

0.45

His-Thr-Glu-Phe-Leu-Val-Thr-Ser

Agkistrodon contortrix

-

-

668337, 670960

1.59

His-Thr-Glu-Pro-Leu-Val-Thr-Ser

Agkistrodon contortrix

-

-

668337, 670960

3.98

His-Thr-Glu-Ser-Leu-Val-Thr-Ser

Agkistrodon contortrix

-

-

668337, 670960

0.09

Leu-Val-Glu-Ala-Leu-Tyr-Leu-Val

Agkistrodon contortrix

-

-

668337, 670960

0.0086

low molecular weight kininogen

Agkistrodon contortrix

-

-

668337, 670960

-

additional information

Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg

2 entries

additional information

Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg

Agkistrodon contortrix

-

-

668337

additional information

Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg

Agkistrodon contortrix

-

-

670960