3.4.24.72: fibrolase

This is an abbreviated version!
For detailed information about fibrolase, go to the full flat file.

Word Map on EC 3.4.24.72

3.4.24.72

plasmin

thrombolytic

copperhead

fibrinogenolytic

medicine

nonhemorrhagic

neuwiedi

alteplase

pharmacology

drug development

Reaction

Hydrolysis of -Ala14-/-Leu- in insulin B chain and -Lys413-/-Leu- in Aalpha-chain of fibrinogen =

Synonyms

3-203-fibrolase[3-serine], AfeE, Agkistrodon contortrix contortrix metalloproteinase, ALF, Alfimeprase, brevilysin L6, brevithrombolase, broad bean-fibrinolytic enzyme, CFR15-protease, fibrinolytic enzyme, fibrinolytic protease, Fibrinolytic proteinase, FIIa, neuwiedase, Non-hemorrhagic fibrinolytic metalloproteinase, plasmin, Proteinase, Agkistrodon contortrix contortrix venom metallo-, snake venom fibrinolytic enzyme, starase, UFEIII, VlF, wulfase

ECTree

3 Hydrolases

3.4 Acting on peptide bonds (peptidases)

3.4.24 Metalloendopeptidases

3.4.24.72 fibrolase

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Results	in table
12	Activating Compound
6	AA Sequence
13	Application
1	CAS Registry Number
6	Cloned(Commentary)
1	Crystallization (Commentary)
120	Disease/ Diagnostics
5	Expression
2	General Information
1	General Stability
1	IC50 Value
183	Inhibitors
1	Ki Value [mM]
33	KM Value [mM]
6	Localization
55	Metals/Ions
29	Molecular Weight [Da]
39	Natural Substrates/ Products (Substrates)
61	Organism
18	pH Optimum
11	pH Range
12	pH Stability
9	pI Value
3	Posttranslational Modification
1	Protein Variants
26	Purification (Commentary)
1	Reaction
1	Reaction Type
61	Reference
1	Renatured (Commentary)
27	Source Tissue
10	Specific Activity [micromol/min/mg]
4	Storage Stability
214	Substrates and Products (Substrate)
36	Subunits
62	Synonyms
20	Temperature Optimum [°C]
8	Temperature Range [°C]
13	Temperature Stability [°C]
30	Turnover Number [1/s]

Expression

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Expression on EC 3.4.24.72 - fibrolase

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cotton cake as nitrogen source enhances fibrinolytic protease production substantially (71%) as compared to control

2 entries

soybean meal supports maximum protease production, followed by malt extract, cotton cake, gelatin and beef extract

2 entries

the optimal conditions to obtain high protease production are 1.26% soybean flour and 1.23% glucose concentration

Streptomyces sp.

733714