3.4.24.72: fibrolase

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For detailed information about fibrolase, go to the full flat file.

Reaction

Hydrolysis of -Ala14-/-Leu- in insulin B chain and -Lys413-/-Leu- in Aalpha-chain of fibrinogen =

Synonyms

3-203-fibrolase[3-serine], AfeE, Agkistrodon contortrix contortrix metalloproteinase, ALF, Alfimeprase, brevilysin L6, brevithrombolase, broad bean-fibrinolytic enzyme, CFR15-protease, fibrinolytic enzyme, fibrinolytic protease, Fibrinolytic proteinase, FIIa, neuwiedase, Non-hemorrhagic fibrinolytic metalloproteinase, plasmin, Proteinase, Agkistrodon contortrix contortrix venom metallo-, snake venom fibrinolytic enzyme, starase, UFEIII, VlF, wulfase

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.24 Metalloendopeptidases

                3.4.24.72 fibrolase

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Results	in table
12	Activating Compound
6	AA Sequence
13	Application
1	CAS Registry Number
6	Cloned(Commentary)
1	Crystallization (Commentary)
120	Disease/ Diagnostics
5	Expression
2	General Information
1	General Stability
1	IC50 Value
183	Inhibitors
1	Ki Value [mM]
33	KM Value [mM]
6	Localization
55	Metals/Ions
29	Molecular Weight [Da]
39	Natural Substrates/ Products (Substrates)
61	Organism
18	pH Optimum
11	pH Range
12	pH Stability
9	pI Value
3	Posttranslational Modification
1	Protein Variants
26	Purification (Commentary)
1	Reaction
1	Reaction Type
61	Reference
1	Renatured (Commentary)
27	Source Tissue
10	Specific Activity [micromol/min/mg]
4	Storage Stability
214	Substrates and Products (Substrate)
36	Subunits
62	Synonyms
20	Temperature Optimum [°C]
8	Temperature Range [°C]
13	Temperature Stability [°C]
30	Turnover Number [1/s]

Engineering

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Engineering on EC 3.4.24.72 - fibrolase

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PROTEIN VARIANTS

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

additional information

Agkistrodon contortrix contortrix

-

construction of a heterobifunctional chimeric derivative of fibrolase through linking covalently with a RGD-like peptide via a surface residue distant from the active site, structure, overview, the chimera shows fibrolase and platelet-binding ability, the chimeric enzyme exhibits an IC50 of 105 nM in inhibition of platelet aggregation, overview

684096