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3.4.24.71: endothelin-converting enzyme 1

This is an abbreviated version!
For detailed information about endothelin-converting enzyme 1, go to the full flat file.

Word Map on EC 3.4.24.71

Reaction

Hydrolysis of the -Trp21-/-Val- bond in big endothelin to form endothelin 1 =

Synonyms

ECE, ECE-1, ECE-1b, ECE-3, ECE1, endothelin converting enzyme, endothelin converting enzyme-1, Endothelin-converting enzyme, endothelin-converting enzyme 1, endothelin-converting enzyme 1 (ECE-1), endothelin-converting enzyme I, endothelin-converting enzyme-1, endothelin-converting-enzyme-1, ET converting enzyme, hECE-1, More, sECE, solECE-1

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.24 Metalloendopeptidases
                3.4.24.71 endothelin-converting enzyme 1

Natural Substrates Products

Natural Substrates Products on EC 3.4.24.71 - endothelin-converting enzyme 1

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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
amyloid beta peptide + H2O
?
show the reaction diagram
amyloid-beta peptide + H2O
?
show the reaction diagram
angiotensin I + H2O
?
show the reaction diagram
-
-
-
?
angiotensin-I + H2O
?
show the reaction diagram
-
degradation, no activity with angiotensin-II
-
-
?
big endothelin + H2O
endothelin + ?
show the reaction diagram
big endothelin + H2O
endothelin 1 + ?
show the reaction diagram
-
-
-
-
?
big endothelin + H2O
endothelin-1 + ?
show the reaction diagram
Big endothelin 1 + H2O
?
show the reaction diagram
-
key enzyme in endothelin production, generates potent vasoconstrictor endothelin from its inactive precursor
-
-
?
big endothelin-1 + H2O
big endothelin fragment 22-38 + ?
show the reaction diagram
-
-
-
?
big endothelin-1 + H2O
endothelin + ?
show the reaction diagram
big endothelin-1 + H2O
endothelin-1 + ?
show the reaction diagram
big endothelin-3 + H2O
endothelin-3 + ?
show the reaction diagram
-
specific for this substrate, big-endothelin-1 is no substrate
-
?
big endothelin-I + H2O
endothelin + ?
show the reaction diagram
-
key enzyme in the biosynthesis of the endothelins
-
?
bradykinin + H2O
?
show the reaction diagram
calcitonin gene-related peptide + H2O
?
show the reaction diagram
-
degradation, co-internalization with ECE-1 into early endosomes, calcitonin gene-related peptide degradation promotes CLR/RAMP1 recycling and beta-arrestin2 redistribution into the cytosol, ECE-1 inhibition or knockdown traps CLR/RAMP1 and beta-arrestin2 in endosomes and inhibits CLR/RAMP1 recycling and resensitization, whereas ECE-1 overexpression has the opposite effect, mechanism, overview
-
-
?
neurotensin + H2O
?
show the reaction diagram
-
-
-
?
preendothelin + H2O
endothelin + ?
show the reaction diagram
-
-
-
?
preproendothelin-1 + H2O
endothelin-1 + ?
show the reaction diagram
-
-
-
-
?
proendothelin + H2O
endothelin-1 + ?
show the reaction diagram
-
-
-
?
proendothelin-1 + H2O
endothelin + ?
show the reaction diagram
activation
-
-
?
somatostatin + H2O
?
show the reaction diagram
-
-
-
?
Substance P + H2O
?
show the reaction diagram
additional information
?
-