3.4.24.70: oligopeptidase A

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For detailed information about oligopeptidase A, go to the full flat file.

Reaction

hydrolysis of oligopeptides, with broad specificity. Gly or Ala commonly occur as P1 or P1' residues, but additional information distant residues are also important, as is shown by the fact that Z-Gly-Pro-Gly-/-Gly-Pro-Ala is cleaved, but not Z-(Gly)5 =

Synonyms

68000-M Signalpeptide hydrolase, More, oligopeptidase A, OpdA, prlC, TOP, Top1, Top2

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.24 Metalloendopeptidases

                3.4.24.70 oligopeptidase A

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Results	in table
13052	AA Sequence
2	CAS Registry Number
14	Cloned(Commentary)
1	Cofactor
1	Crystallization (Commentary)
1	Expression
7	General Information
23	Inhibitors
14	kcat/KM [mM/s]
15	KM Value [mM]
6	Localization
18	Metals/Ions
4	Molecular Weight [Da]
6	Natural Substrates/ Products (Substrates)
62	Organism
1	PDB ID
3	pH Optimum
1	pH Range
3	Protein Variants
10	Purification (Commentary)
2	Reaction
1	Reaction Type
60	Reference
1	Source Tissue
5	Specific Activity [micromol/min/mg]
1	Storage Stability
57	Substrates and Products (Substrate)
3	Subunits
57	Synonyms
6	Temperature Optimum [°C]
14	Turnover Number [1/s]

Reaction

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Reaction on EC 3.4.24.70 - oligopeptidase A

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REACTION

REACTION DIAGRAM

COMMENTARY

ORGANISM

UNIPROT

LITERATURE

hydrolysis of oligopeptides, with broad specificity. Gly or Ala commonly occur as P1 or P1' residues, but more distant residues are also important, as is shown by the fact that Z-Gly-Pro-Gly-/-Gly-Pro-Ala is cleaved, but not Z-(Gly)5

2 entries

hydrolysis of oligopeptides, with broad specificity. Gly or Ala commonly occur as P1 or P1' residues, but more distant residues are also important, as is shown by the fact that Z-Gly-Pro-Gly-/-Gly-Pro-Ala is cleaved, but not Z-(Gly)5

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hydrolysis of oligopeptides, with broad specificity. Gly or Ala commonly occur as P1 or P1' residues, but more distant residues are also important, as is shown by the fact that Z-Gly-Pro-Gly-/-Gly-Pro-Ala is cleaved, but not Z-(Gly)5

the Tyr607 residue is involved in the recognition of the substrate with a key role in catalysis, it plays an important role in the enzyme-substrate interaction and in the hydrolytic activity

Escherichia coli

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707285