3.4.24.70: oligopeptidase A
This is an abbreviated version!
For detailed information about oligopeptidase A, go to the full flat file.
Word Map on EC 3.4.24.70
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3.4.24.70
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prolyl
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typhimurium
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dipeptidyl
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carboxypeptidase
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neuropeptides
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endopeptidases
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oxyanion
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subtilisin
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octapeptide
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post-proline
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thimet
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neurolysin
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z-pro-prolinal
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bell-shaped
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product-like
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scissile
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3.4.24.15
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arrhenius
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metallopeptidase
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bradykinin
- 3.4.24.70
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prolyl
- typhimurium
-
dipeptidyl
- carboxypeptidase
- neuropeptides
- endopeptidases
-
oxyanion
- subtilisin
- octapeptide
-
post-proline
-
thimet
- neurolysin
- z-pro-prolinal
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bell-shaped
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product-like
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scissile
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3.4.24.15
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arrhenius
- metallopeptidase
- bradykinin
Reaction
hydrolysis of oligopeptides, with broad specificity. Gly or Ala commonly occur as P1 or P1' residues, but additional information distant residues are also important, as is shown by the fact that Z-Gly-Pro-Gly-/-Gly-Pro-Ala is cleaved, but not Z-(Gly)5 =
Synonyms
68000-M Signalpeptide hydrolase, More, oligopeptidase A, OpdA, prlC, TOP, Top1, Top2
ECTree
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Inhibitors
Inhibitors on EC 3.4.24.70 - oligopeptidase A
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phenylmethylsulfonyl fluoride
PMSF, 80% inhibition at 1 mM
salicylate
interacts with the isozyme and inhibits its peptidase activity to various degrees both in vitro and in plant extracts; interacts with the isozyme and inhibits its peptidase activity to various degrees both in vitro and in plant extracts. Specific isozyme TOP2salicylate interaction may be dependent on plant-specific modifications of isozyme TOP2
salicylic acid
inhibits the peptidase activity of isozyme TOP1 and to a lesser extent isozyme TOP2; inhibits the peptidase activity of isozyme TOP1 and to a lesser extent isozyme TOP2
trans-epoxysuccinyl L-leucylamido-(4-guanidino)butane
E-64, 25% inhibition at 0.01 mM
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not inhibited by 0.2 mM leupeptin, 0.1 mM PMSF, 0.1 mM E-64, 0.001 mM Z-pro-prolinal and 0.02 mM captopril
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additional information
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not inhibited by captopril
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