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3.4.24.7: interstitial collagenase

This is an abbreviated version!
For detailed information about interstitial collagenase, go to the full flat file.

Word Map on EC 3.4.24.7

Reaction

Cleavage of the triple helix of collagen at about three-quarters of the length of the molecule from the N-terminus, at Gly775-/-Ile in the alpha1(I) chain. Cleaves synthetic substrates and alpha-macroglobulins at bonds where P1' is a hydrophobic residue =

Synonyms

azocollase, collagen peptidase, collagen protease, collagenase, collagenase 1, collagenase A, collagenase MMP-1, collagenase-1, collagenolytic matrix metalloproteinase, EC 3.4.99.5, ect-MMP-14, Fibroblast collagenase, HSFC, kollaza, macrophage matrix metalloproteinase, matrix metalloproteinase 1, matrix metalloproteinase-1, matrix metalloproteinase-18, matrix-metalloproteinase-1, membrane-type 1-MMP, metallocollagenase, metalloproteinase-1, MMP-1, MMP-12, MMP-14, MMP-1A, mmp1, MT1-MMP, Myocardial collagenase, nucleolysin, soycollagestin, TC1, tumor collagenase, vertebrate collagenase

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.24 Metalloendopeptidases
                3.4.24.7 interstitial collagenase

Source Tissue

Source Tissue on EC 3.4.24.7 - interstitial collagenase

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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
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MMP-1 is upregulated by TGF-beta, EGF and IL-1beta
Manually annotated by BRENDA team
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cell line JJ, increased MMP1 expression in chondrosarcoma, mechanism, overview
Manually annotated by BRENDA team
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mucosa, immunohistochemic analysis of MMP-1 and TIMP-1 levels, overview. Overall plasma levels of MMP-1 and TIMP-1 in ulcerative colitis patients are significantly higher than those of the control group
Manually annotated by BRENDA team
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acceleration of matrix metalloproteinase-1 production by oxidized low-sensity lipoprotein and 4-hydroxynonenal
Manually annotated by BRENDA team
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MMP-1 is expressed by migrating enterocytes bordering intestinal ulcers. In the fetal gut model, MMP-1 expression by migrating enterocytes is detected
Manually annotated by BRENDA team
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primary epithelial ovarian tumor cell
Manually annotated by BRENDA team
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MMP-14 is expressed and active in cultured ES2 cells. ES2 cells also exhibit MMP-dependent invasion of and proliferation within three-dimensional collagen gels
Manually annotated by BRENDA team
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immortalized human keratinocyte cells
Manually annotated by BRENDA team
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MMP-10 and MMP-1 are up-regulated in HaCaT II-4 cells
Manually annotated by BRENDA team
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the MMP-1 levels are altered in the left ventricle and serum in case of hypertrophy through hyperthyroid conditions with 3,5,3'-triiodo-L-thyroine or dexamethasone application, tissue distribution, overview
Manually annotated by BRENDA team
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glycine-extended gastrin renders colon cancer cells more invasive by increasing MMP-I expression via the putative glycine-extended gastrin receptor
Manually annotated by BRENDA team
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primary, monocyte-derived
Manually annotated by BRENDA team
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high MMP-1 level
Manually annotated by BRENDA team
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Muller glia cell line
Manually annotated by BRENDA team
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saphenous vein smooth muscle
Manually annotated by BRENDA team
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UM1 and UM2 are oral tongue squamous cell carcinoma cell lines
Manually annotated by BRENDA team
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ovarian clear cell carcinoma cell
Manually annotated by BRENDA team
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follicular expression of MMP-1 increases following the gonadotropin surge. Abundance of MMP-1 mRNA increases at 6, 12, and 48 h post-gonadotropin releasing hormone injection. MMP-1 is localized to granulosal and thecal layers of preovulatory follicles. MMP-1 is increased in bovine preovulatory follicles following the gonadotropin surge
Manually annotated by BRENDA team
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enzyme expression is significantly stronger in the epithelium than in the stroma
Manually annotated by BRENDA team
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the mean salivary MMP-1 concentration in patients with chronic periodontitis is significantly higher before and after treatment with aprotinin, as compared to healthy subjects
Manually annotated by BRENDA team
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disruption of caveolae by addition of methyl-beta-cyclodextrin results in a dramatic decline in both motility and invasion abilities of cells with concomitant increase in secreted MMP-2 expression and expression levels of MMP-1 and MMP-9
Manually annotated by BRENDA team
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disruption of caveolae by addition of methyl-beta-cyclodextrin results in a dramatic decline in both motility and invasion abilities of cells with concomitant increase in secreted MMP-2 expression and expression levels of MMP-1 and MMP-9
Manually annotated by BRENDA team
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SCL-1 cell. MMP-1 is upregulated 4 h after UVA and 16 h after UVB irradiation of tumor cells. Incubation of cells with the MEK1/2 inhibitor U0126 or the p38 inhibitor SB202190 abolishes the UVA and UVB mediated induction of MMP-1
Manually annotated by BRENDA team
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a human chondrosarcoma cell line
Manually annotated by BRENDA team
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rheumatoid
Manually annotated by BRENDA team
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fibroblast-like, from rheumatoid arthritis patients
Manually annotated by BRENDA team
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Manually annotated by BRENDA team
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from Achilles tendon, immunohistochemic analysis of MMP-1, overview
Manually annotated by BRENDA team
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leg ulcer tissue from patients with chronic venous insufficiency
Manually annotated by BRENDA team
additional information