3.4.24.7: interstitial collagenase

This is an abbreviated version!
For detailed information about interstitial collagenase, go to the full flat file.

Reaction

Cleavage of the triple helix of collagen at about three-quarters of the length of the molecule from the N-terminus, at Gly775-/-Ile in the alpha1(I) chain. Cleaves synthetic substrates and alpha-macroglobulins at bonds where P1' is a hydrophobic residue =

Synonyms

azocollase, collagen peptidase, collagen protease, collagenase, collagenase 1, collagenase A, collagenase MMP-1, collagenase-1, collagenolytic matrix metalloproteinase, EC 3.4.99.5, ect-MMP-14, Fibroblast collagenase, HSFC, kollaza, macrophage matrix metalloproteinase, matrix metalloproteinase 1, matrix metalloproteinase-1, matrix metalloproteinase-18, matrix-metalloproteinase-1, membrane-type 1-MMP, metallocollagenase, metalloproteinase-1, MMP-1, MMP-12, MMP-14, MMP-1A, mmp1, MT1-MMP, Myocardial collagenase, nucleolysin, soycollagestin, TC1, tumor collagenase, vertebrate collagenase

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.24 Metalloendopeptidases

                3.4.24.7 interstitial collagenase

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Results	in table
15	Activating Compound
38	AA Sequence
20	Application
1	CAS Registry Number
20	Cloned(Commentary)
2	Crystallization (Commentary)
7719	Disease/ Diagnostics
37	Expression
48	General Information
5	IC50 Value
181	Inhibitors
17	kcat/KM [mM/s]
111	Ki Value [mM]
52	KM Value [mM]
24	Localization
25	Metals/Ions
6	Molecular Weight [Da]
41	Natural Substrates/ Products (Substrates)
139	Organism
26	PDB ID
22	pH Optimum
7	pH Range
1	pH Stability
7	Posttranslational Modification
22	Protein Variants
11	Purification (Commentary)
1	Reaction
1	Reaction Type
137	Reference
2	Renatured (Commentary)
193	Source Tissue
6	Specific Activity [micromol/min/mg]
190	Substrates and Products (Substrate)
8	Subunits
161	Synonyms
9	Temperature Optimum [°C]
2	Temperature Stability [°C]
47	Turnover Number [1/s]

Natural Substrates Products

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Natural Substrates Products on EC 3.4.24.7 - interstitial collagenase

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

Collagen + H2O

?

3 entries

collagen I + H2O

?

2 entries

collagen III + H2O

?

Rattus norvegicus

-

degradation

683845

-

-

?

Collagen type I + H2O

?

Homo sapiens

P03956

-

754720

-

-

?

Collagen type III + H2O

?

2 entries

Type I collagen + H2O

?

6 entries

type I procollagen + H2O

type I collagen + ?

Homo sapiens

-

-

709482

-

-

?

type II collagen + H2O

?

Homo sapiens

-

interstitial collagen

709415

-

-

?

type III collagen + H2O

?

2 entries

additional information

?

-

11 entries

Collagen + H2O

?

Homo sapiens

P03956

-

755250

-

-

?

Collagen + H2O

?

Rattus norvegicus

B5DFD5

-

753882, 755250

-

-

?

Collagen + H2O

?

Rattus norvegicus Sprague-Dawley

B5DFD5

-

753882

-

-

?

collagen I + H2O

?

Homo sapiens

-

degradation

683445, 683451, 683633, 683988

-

-

?

collagen I + H2O

?

Rattus norvegicus

-

degradation

683845

-

-

?

Collagen type III + H2O

?

Homo sapiens

P03956

-

752753

-

-

?

Collagen type III + H2O

?

Homo sapiens

P03956

ability of MMP-1 to unwind triple-helical collagen

752420

-

-

?

Type I collagen + H2O

?

Bos taurus

-

-

709025

-

-

?

Type I collagen + H2O

?

Homo sapiens

-

-

707313, 707397, 708432, 708587, 709025, 709234, 709289, 709789

-

-

?

Type I collagen + H2O

?

Homo sapiens

-

a plasmin/MMP-10/MMP-1 proteolytic axis effectively enhances collagen type 1 degradation

707982

-

-

?

Type I collagen + H2O

?

Homo sapiens

-

interstitial collagen

709415

-

-

?

Type I collagen + H2O

?

Homo sapiens

-

production of type I collagen by periodontal ligament cells

708406

-

-

?

Type I collagen + H2O

?

Rattus norvegicus

-

-

709661

-

-

?

type III collagen + H2O

?

Homo sapiens

-

-

709789

-

-

?

type III collagen + H2O

?

Homo sapiens

-

interstitial collagen

709415

-

-

?

additional information

?

-

Homo sapiens

-

ligation of keratinocyte alpha2beta1 integrin by type 1 collagen induces expression of matrix metalloproteinase-1. The MMP-1 activity is required for the alpha2beta1 integrin-dependent migration of primary keratinocytes across collagenous matrices. MMP-1 binds to the I domain of the alpha2 intergrin subunit

656016

-

-

?

additional information

?

-

Homo sapiens

-

matrix metalloproteinase 1 interacts with neuronal integrins and stimulates dephosphorylation of Akt and neuronal death through a non-proteolytic mechanism. MMP-1 might contribute to the neuronal damage which occurs in association with degenerative and inflammatpry conditions characterized by elevated levels of this proteinase

656272

-

-

?

additional information

?

-

Homo sapiens

-

MMP-1 is involved in intestinal re-epithelization in vivo and is upregulated by cytokines relevant in wound repair

670882

-

-

?

additional information

?

-

Homo sapiens

-

enzyme regulation on expression and protein levels, overview

683633

-

-

?

additional information

?

-

Homo sapiens

-

MMP-1 is a single effector of the Raf/MEK/ERK signaling cascade, that prevents progression of melanoma from a primary to metastatic tumor

683330

-

-

?

additional information

?

-

Homo sapiens

-

MMP1 expression is increased in Xeroderma pigmentosum, a rare, recessively inherited genetic disease characterized by skin cancer proneness and premature aging in photoexposed area

682206

-

-

?

additional information

?

-

Homo sapiens

-

substance P up-regulates matrix metalloproteinase-1 and down-regulates collagen in human lung fibroblast, overview

683445

-

-

?

additional information

?

-

Homo sapiens

-

active MMP-10, EC 3.4.24.22, does not cleave collagen type 1 directly, it does activate the collagenase MMP-1

707982

-

-

?

additional information

?

-

Homo sapiens

-

matrix metalloproteinases are endopeptidases capable of cleaving various components of extracellular matrix

709669

-

-

?

additional information

?

-

Homo sapiens

-

MMP-1 cleaves a specific glycine-isoleucine or glycine-leucine bond in fibrillar collagens, despite the presence of this sequence in other parts of the protein

709789

-

-

?

additional information

?

-

Rattus norvegicus

-

myocardial matrix degradation by MMP-1 induced by thyroid hormone through enzyme activation, enzyme regulation involving suppression of tissue inhibitors of matrix metalloproteinases TIMPs and distribution, overview

683845

-

-

?