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3.4.24.7: interstitial collagenase

This is an abbreviated version!
For detailed information about interstitial collagenase, go to the full flat file.

Word Map on EC 3.4.24.7

Reaction

Cleavage of the triple helix of collagen at about three-quarters of the length of the molecule from the N-terminus, at Gly775-/-Ile in the alpha1(I) chain. Cleaves synthetic substrates and alpha-macroglobulins at bonds where P1' is a hydrophobic residue =

Synonyms

azocollase, collagen peptidase, collagen protease, collagenase, collagenase 1, collagenase A, collagenase MMP-1, collagenase-1, collagenolytic matrix metalloproteinase, EC 3.4.99.5, ect-MMP-14, Fibroblast collagenase, HSFC, kollaza, macrophage matrix metalloproteinase, matrix metalloproteinase 1, matrix metalloproteinase-1, matrix metalloproteinase-18, matrix-metalloproteinase-1, membrane-type 1-MMP, metallocollagenase, metalloproteinase-1, MMP-1, MMP-12, MMP-14, MMP-1A, mmp1, MT1-MMP, Myocardial collagenase, nucleolysin, soycollagestin, TC1, tumor collagenase, vertebrate collagenase

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.24 Metalloendopeptidases
                3.4.24.7 interstitial collagenase

Cloned

Cloned on EC 3.4.24.7 - interstitial collagenase

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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expressed in Escherichia coli strain BL21(DE3)
expression analysis
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expression analysis of MMP1 in cancerous and healthy oral tissues, overview
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expression in Escherichia coli
gene MMP-1, quantitative RT-PCR expression analysis
integrity of MMP-1 promoter AP-1 binding site is necessary for transactivation by rapamycin, regulation, overview
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MMP-1 expression anaylsis, overview
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MMP-3/MMP-1 chimeras and variants are overexpressed in Escherichia coli, folded from inclusion bodies and isolated as zymogens
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quantitative MMP-1 expression analysis
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quantitative MMP-1 expression analysis in primary dermal fibroblasts
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quantitative MMP-1 expression analysis in skin fibroblasts
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quantitative MMP-1 expression analysis, overview
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quantitiative real-time PCR expression analysis of MMP-1 in brain regions in response to infection with Mycobacterium tuberculosis
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recombinant expression in bacterial cells
recombinant expression of His-tagged isolated MMP-1 catalytic domain as soluble cytoplasmic protein in Escherichia coli
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sitting drop vapor diffusion technique. Crystallization of recombinant human proMMP-1 and determination of its structure to 2.2 A resolution
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the enzyme forms insoluble inclusion bodies when over-expressed in Escherichia coli
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