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3.4.24.65: macrophage elastase

This is an abbreviated version!
For detailed information about macrophage elastase, go to the full flat file.

Word Map on EC 3.4.24.65

Reaction

Hydrolysis of soluble and insoluble elastin. Specific cleavages are also produced at -Ala14-/-Leu- and -Tyr16-/-Leu- in the B chain of insulin =

Synonyms

HME, hMMP-12, human macrophage elastase, Human macrophage metalloelastase, human metalloelastase, Macrophage elastase, macrophage matrix metalloproteinase, macrophage metalloelastase, macrophage-specific metalloelastase, matrix metalloproteinase 12, Matrix metalloproteinase-12, ME, Metalloelastase, MME, MMP-12, MMP12, More, mouse macrophage metalloelastase, rHME

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.24 Metalloendopeptidases
                3.4.24.65 macrophage elastase

Substrates Products

Substrates Products on EC 3.4.24.65 - macrophage elastase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
2,4-dinitrophenyl-Arg-Pro-Leu-Ala-Ala-Trp-Arg-Ser-NH2 + H2O
?
show the reaction diagram
-
-
-
?
2,4-dinitrophenyl-Arg-Pro-Leu-Ala-Arg-Trp-Arg-Ser-NH2 + H2O
?
show the reaction diagram
-
-
-
?
2,4-dinitrophenyl-Arg-Pro-Leu-Ala-Glu-Trp-Arg-Ser-NH2 + H2O
?
show the reaction diagram
-
-
-
?
2,4-dinitrophenyl-Arg-Pro-Leu-Ala-Leu-Trp-Arg-Ser-NH2 + H2O
?
show the reaction diagram
-
-
-
?
2,4-dinitrophenyl-Arg-Pro-Leu-Ala-Lys-Trp-Arg-Ser-NH2 + H2O
?
show the reaction diagram
-
-
-
?
2,4-dinitrophenyl-Arg-Pro-Leu-Ala-Phe-Trp-Arg-Ser-NH2 + H2O
?
show the reaction diagram
-
-
-
?
2,4-dinitrophenyl-Arg-Pro-Leu-Ala-Ser-Trp-Arg-Ser-NH2 + H2O
?
show the reaction diagram
-
-
-
?
2,4-dinitrophenyl-Arg-Pro-Leu-Ala-Trp-Trp-Arg-Ser-NH2 + H2O
?
show the reaction diagram
-
-
-
?
2,4-dinitrophenyl-Arg-Pro-Leu-Ala-Tyr-Trp-Arg-Ser-NH2 + H2O
?
show the reaction diagram
-
-
-
?
2-aminobenzoyl-ASVATELRAQ-2-(2,4-dinitrophenyl)aminoethylamide + H2O
2-aminobenzoyl-ASVATE + LRAQ-2-(2,4-dinitrophenyl)aminoethylamide
show the reaction diagram
2-aminobenzoyl-EAAPSSVIAATE-2-(2,4-dinitrophenyl)aminoethylamide + H2O
?
show the reaction diagram
2-aminobenzoyl-EPLALWRSQ-2-(2,4-dinitrophenyl)aminoethylamide + H2O
2-aminobenzoyl-EPLA + LWRSQ-2-(2,4-dinitrophenyl)aminoethylamide
show the reaction diagram
2-aminobenzoyl-GAMFLEAIPMSIP-2-(2,4-dinitrophenyl)aminoethylamide + H2O
2-aminobenzoyl-GAMF + LEAIPMSIP-2-(2,4-dinitrophenyl)aminoethylamide
show the reaction diagram
2-aminobenzoyl-GPLELEEAQ-2-(2,4-dinitrophenyl)aminoethylamide + H2O
2-aminobenzoyl-GPLE + LEEAQ-2-(2,4-dinitrophenyl)aminoethylamide
show the reaction diagram
2-aminobenzoyl-GPLGLERAQ-2-(2,4-dinitrophenyl)aminoethylamide + H2O
2-aminobenzoyl-GPLG + LERAQ-2-(2,4-dinitrophenyl)aminoethylamide
show the reaction diagram
2-aminobenzoyl-GPLGLREAQ-2-(2,4-dinitrophenyl)aminoethylamide + H2O
2-aminobenzoyl-GPLG + LREAQ-2-(2,4-dinitrophenyl)aminoethylamide
show the reaction diagram
2-aminobenzoyl-PLALWRSQ-2-(2,4-dinitrophenyl)aminoethylamide + H2O
2-aminobenzoyl-PLA + LWRSQ-2-(2,4-dinitrophenyl)aminoethylamide
show the reaction diagram
2-aminobenzoyl-PLGLEEA-2-(2,4-dinitrophenyl)aminoethylamide + H2O
2-aminobenzoyl-PLG + LEEA-2-(2,4-dinitrophenyl)aminoethylamide
show the reaction diagram
2-aminobenzoyl-RGLALWRSQ-2-(2,4-dinitrophenyl)aminoethylamide + H2O
2-aminobenzoyl-RGLA + LWRSQ-2-(2,4-dinitrophenyl)aminoethylamide
show the reaction diagram
2-aminobenzoyl-RNALAVERTAS-2-(2,4-dinitrophenyl)aminoethylamide + H2O
2-aminobenzoyl-RNALA + VERTAS-2-(2,4-dinitrophenyl)aminoethylamide
show the reaction diagram
2-aminobenzoyl-RPLALEESQ-2-(2,4-dinitrophenyl)aminoethylamide + H2O
2-aminobenzoyl-RPLA + LEESQ-2-(2,4-dinitrophenyl)aminoethylamide
show the reaction diagram
2-aminobenzoyl-RPLALRRSQ-2-(2,4-dinitrophenyl)aminoethylamide + H2O
2-aminobenzoyl-RPLA + LRRSQ-2-(2,4-dinitrophenyl)aminoethylamide
show the reaction diagram
2-aminobenzoyl-RPLALWEEQ-2-(2,4-dinitrophenyl)aminoethylamide + H2O
2-aminobenzoyl-RPLA + LWEEQ-2-(2,4-dinitrophenyl)aminoethylamide
show the reaction diagram
2-aminobenzoyl-RPLALWESQ-2-(2,4-dinitrophenyl)aminoethylamide + H2O
2-aminobenzoyl-RPLA + LWESQ-2-(2,4-dinitrophenyl)aminoethylamide
show the reaction diagram
2-aminobenzoyl-RPLALWRSQ-2-(2,4-dinitrophenyl)aminoethylamide + H2O
2-aminobenzoyl-RPLA + LWRSQ-2-(2,4-dinitrophenyl)aminoethylamide
show the reaction diagram
2-aminobenzoyl-RPLELWRSQ-2-(2,4-dinitrophenyl)aminoethylamide + H2O
2-aminobenzoyl-RPLE + LWRSQ-2-(2,4-dinitrophenyl)aminoethylamide
show the reaction diagram
2-aminobenzoyl-RPLGLEEA-2-(2,4-dinitrophenyl)aminoethylamide + H2O
2-aminobenzoyl-RPLG + LEEA-2-(2,4-dinitrophenyl)aminoethylamide
show the reaction diagram
2-aminobenzoyl-RPLGLGAAQ-2-(2,4-dinitrophenyl)aminoethylamide + H2O
2-aminobenzoyl-RPLG + LGAAQ-2-(2,4-dinitrophenyl)aminoethylamide
show the reaction diagram
2-aminobenzoyl-RPLGLGGAQ-2-(2,4-dinitrophenyl)aminoethylamide + H2O
2-aminobenzoyl-RPLG + LGGAQ-2-(2,4-dinitrophenyl)aminoethylamide
show the reaction diagram
2-aminobenzoyl-RPLGLWGAQ-2-(2,4-dinitrophenyl)aminoethylamide + H2O
2-aminobenzoyl-RPLG + LWGAQ-2-(2,4-dinitrophenyl)aminoethylamide
show the reaction diagram
alpha-1-antitrypsin + H2O
?
show the reaction diagram
-
recombinant enzyme rHME
-
?
alpha-casein + H2O
?
show the reaction diagram
-
-
-
-
?
alpha1-antitrypsin + H2O
?
show the reaction diagram
beta-casein + H2O
?
show the reaction diagram
-
-
-
-
?
casein + H2O
?
show the reaction diagram
chondroitan sulfate + H2O
?
show the reaction diagram
-
recombinant enzyme rHME
-
?
Collagen type I + H2O
?
show the reaction diagram
-
the potential of MMP-12 in recognizing sites in human skin collagen types I and III has been investigated. The catalytic domain of MMP-12 binds to the triple helix and cleaves the typical sites -Gly775-Leu776- in alpha-2 type I collagen and -Gly775-Ile776- in alpha-1 type I and type III collagens and at multiple other sites in both collagen types. The region around these typical sites contains comparatively less prolines, of which some have been proven to be only partially hydroxylated
-
-
?
Collagen type III + H2O
?
show the reaction diagram
-
the potential of MMP-12 in recognizing sites in human skin collagen types I and III has been investigated. The catalytic domain of MMP-12 binds to the triple helix and cleaves the typical sites -Gly775-Leu776- in alpha-2 type I collagen and -Gly775-Ile776- in alpha-1 type I and type III collagens and at multiple other sites in both collagen types. The region around these typical sites contains comparatively less prolines, of which some have been proven to be only partially hydroxylated
-
-
?
DQ-collagen I + H2O
?
show the reaction diagram
-
-
-
-
?
DQ-collagen IV + H2O
?
show the reaction diagram
-
-
-
-
?
Elastin + H2O
?
show the reaction diagram
elastin fELN-125 + H2O
?
show the reaction diagram
-
-
-
-
?
enactin + H2O
?
show the reaction diagram
-
recombinant enzyme rHME
-
?
extracellular matrix protein + H2O
?
show the reaction diagram
-
may be required for macrophages to penetrate basement membranes and remodel injured tissue during inflammation
-
?
fEln-100 + H2O
?
show the reaction diagram
-
alpha-elastin
-
-
?
Fibronectin + H2O
?
show the reaction diagram
Gelatin + H2O
?
show the reaction diagram
heparan sulfate + H2O
?
show the reaction diagram
-
recombinant enzyme rHME
-
?
human apolipoprotein (alpha) + H2O
?
show the reaction diagram
-
cleaves in the linker region between kringles IV-4 and IV-5
-
?
Insulin B-chain + H2O
?
show the reaction diagram
-
hydrolyzes Ala-Leu and Tyr-Leu, not His10-Leu11, on amino side of Leu-residue, not Val-residue
-
-
?
Laminin + H2O
?
show the reaction diagram
Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 + H2O
?
show the reaction diagram
Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 + H2O
Mca-Pro-Leu-Gly + Leu-Dpa-Ala-Arg-NH2
show the reaction diagram
-
-
-
-
?
Mca-Pro-Leu-Gly-Leu-Glu-Glu-Ala-Dpa-NH2 + H2O
Mca-Pro-Leu-Gly + Leu-Glu-Glu-Ala-Dpa-NH2
show the reaction diagram
-
selective cleavage, the Glu-Glu motif interacts with the S'2 and S'3 subsites of MMP-12
-
-
?
TNF-alpha + H2O
?
show the reaction diagram
triple helical peptide alpha1(V) + H2O
?
show the reaction diagram
-
collagen V fibrils
-
-
?
Type IV collagen + H2O
?
show the reaction diagram
type-IV collagen + H2O
?
show the reaction diagram
-
degradation
-
-
?
Elastin + H2O
additional information
-