3.4.24.65: macrophage elastase

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For detailed information about macrophage elastase, go to the full flat file.

Word Map on EC 3.4.24.65

3.4.24.65

metalloproteinases

mmp-9

pulmonary

emphysema

collagen

alveolar

elastin

fibrosis

smoke

airway

timp-1

cigarette

lavage

bronchoalveolar

endothelial

metastasis

aortic

tnf

artery

chemokine

monocyte

smoking

plaque

aneurysm

angiogenesis

atherosclerotic

zymography

smoke-induced

elastolytic

proteinases

plasminogen

asthma

rupture

angiostatin

bal

instil

urokinase-type

matrilysin

airspace

mt1-mmp

cs-induced

elastases

smoke-exposed

emphysematous

diagnostics

drug development

elastase-induced

collagenase-3

cs-exposed

airflow

medicine

pharmacology

matrix-degrading

analysis

Reaction

Hydrolysis of soluble and insoluble elastin. Specific cleavages are also produced at -Ala14-/-Leu- and -Tyr16-/-Leu- in the B chain of insulin =

Synonyms

HME, hMMP-12, human macrophage elastase, Human macrophage metalloelastase, human metalloelastase, Macrophage elastase, macrophage matrix metalloproteinase, macrophage metalloelastase, macrophage-specific metalloelastase, matrix metalloproteinase 12, Matrix metalloproteinase-12, ME, Metalloelastase, MME, MMP-12, MMP12, More, mouse macrophage metalloelastase, rHME

ECTree

3 Hydrolases

3.4 Acting on peptide bonds (peptidases)

3.4.24 Metalloendopeptidases

3.4.24.65 macrophage elastase

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Results	in table
2	Activating Compound
9	AA Sequence
16	Application
2	CAS Registry Number
18	Cloned(Commentary)
3	Crystallization (Commentary)
2467	Disease/ Diagnostics
7	Expression
17	General Information
6	General Stability
14	IC50 Value
45	Inhibitors
121	kcat/KM [mM/s]
2	Ki Value [mM]
48	KM Value [mM]
21	Localization
11	Metals/Ions
20	Molecular Weight [Da]
31	Natural Substrates/ Products (Substrates)
192	Organism
131	PDB ID
12	pH Optimum
8	Posttranslational Modification
33	Protein Variants
11	Purification (Commentary)
1	Reaction
1	Reaction Type
53	Reference
2	Renatured (Commentary)
72	Source Tissue
3	Specific Activity [micromol/min/mg]
1	Storage Stability
141	Substrates and Products (Substrate)
15	Subunits
94	Synonyms
14	Temperature Optimum [°C]
48	Turnover Number [1/s]

Purification

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Purification on EC 3.4.24.65 - macrophage elastase

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2 entries

3 chromatographically distinct forms A, B and C, predominant form is B

Mus musculus

31409

partial, recombinant or native enzyme

Homo sapiens

31412

recombinant C-terminally His-tagged catalytic domain of MMP-12 from Escherichia coli strain BL21(DE3) by nickel affinity chromatography and desalting gel filtration

2 entries

recombinant F171D mutant fragment Gly106-Gly263 from Escherichia coli strain BL21 by gel filtration and anion exchange chromatography

recombinant MMP-12

refolded recombinant MMP-12 catalytic domain from Escherichia coli strain BL21(DE3) inclusion bodies by anion exchange chromatography

Homo sapiens

684029