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3.4.24.65: macrophage elastase

This is an abbreviated version!
For detailed information about macrophage elastase, go to the full flat file.

Word Map on EC 3.4.24.65

Reaction

Hydrolysis of soluble and insoluble elastin. Specific cleavages are also produced at -Ala14-/-Leu- and -Tyr16-/-Leu- in the B chain of insulin =

Synonyms

HME, hMMP-12, human macrophage elastase, Human macrophage metalloelastase, human metalloelastase, Macrophage elastase, macrophage matrix metalloproteinase, macrophage metalloelastase, macrophage-specific metalloelastase, matrix metalloproteinase 12, Matrix metalloproteinase-12, ME, Metalloelastase, MME, MMP-12, MMP12, More, mouse macrophage metalloelastase, rHME

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.24 Metalloendopeptidases
                3.4.24.65 macrophage elastase

Cloned

Cloned on EC 3.4.24.65 - macrophage elastase

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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
cloned and expressed in Escherichia coli BL21(DE3)
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expressed in Escherichia coli
expression analysis
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expression analysis of MMP12 in cancerous and healthy oral tissues, overview
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expression of a cDNA encoding the fragment Gly106-Gly263 of the enzyme F171D mutant in Escherichia coli strain BL21
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gene MMP-12, quantitative real-time PCR enzyme expression analysis
generation of transgenic rabbits that express human (h)MMP-12 gene under the control of a macrophage-specific promoter, the human scavenger receptor promoter. This transgenic rabbit model with increased expression of hMMP-12 may become a useful model for further mechanistic studies of MMP-12 in in inflammatory diseases and cancer invasion, it is also an ideal model for testing the in vivo action of MMP-12 inhibitors
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MMP-12 catalytic domain, cd(EA)MMP-12 overexpressed in Escherichia coli strain BL21 (DE3)
MMP-12 mRNA and protein level increased with the progression of renal disease in glomerulonephritic ICGN mouse compared to non-glomerulonephritic mouse
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molecular cloning of the proteinase domain of MMP12
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overexpression of the MMP-12 catalytic domain, residues Phe100-Gly263, in Escherichia coli strain BL21(DE3) inclusion bodies
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recombinant expression of C-terminally His-tagged catalytic domain of MMP-12 in Escherichia coli strain BL21(DE3)
stable expression of MME domains 1 and 2 in enzyme-deficient murine CT-26 colon cancer cells suppresses orthotopic tumor growth, angiogenesis and vascular endothelial growth factor expression, expression analysis and orthotopic animal tumor model study, overview
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