3.4.24.64: mitochondrial processing peptidase
This is an abbreviated version!
For detailed information about mitochondrial processing peptidase, go to the full flat file.
Word Map on EC 3.4.24.64
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3.4.24.64
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presequence
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nuclear-encoded
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preproteins
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intermembrane
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frataxin
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metalloendopeptidase
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friedreich
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matrix-targeting
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hxxeh
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mas1
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plumbaginifolia
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nuclearly
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matrix-localized
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intermediate-sized
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agriculture
- 3.4.24.64
- presequence
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nuclear-encoded
- preproteins
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intermembrane
- frataxin
- metalloendopeptidase
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friedreich
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matrix-targeting
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hxxeh
- mas1
- plumbaginifolia
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nuclearly
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matrix-localized
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intermediate-sized
- agriculture
Reaction
Release of N-terminal targetting peptides from precursor proteins imported into the mitochondrion, typically with Arg in position P2 =
Synonyms
Alpha-MPP, Atp23, Beta-MPP, EC 3.4.99.41, General mitochondrial processing peptidase, GPP, HA1523, HPP, Imp1, Imp2, inner membrane peptidase processing enzyme, Mas1, Mas2, Matrix peptidase, Matrix processing peptidase, Matrix processing proteinase, Mitochondrial chelator-sensitive protease, mitochondrial processing peptidase, mitochondrial processing peptidase-alpha protein, mitochondrial processing protease, Mitochondrial protein precursor-processing proteinase, MMP-beta, More, MPP, MPP-alpha, P-52, P-55, PEP, Plsp1, Plsp2, PMPCA, Processing enhancing peptidase, processing enhancing protein, processing peptidase, Proteinase, mitochondrial protein precursor-processing, thylakoidal processing peptidase, TPP, TTHA1264
ECTree
3.4.24.64 mitochondrial processing peptidaseAdvanced search results
results (
results (Inhibitors
Inhibitors on EC 3.4.24.64 - mitochondrial processing peptidase
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INHIBITOR 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
IMAGE
3-Oxoacyl-CoA thiolase signal peptide
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weak, cytochrome c oxidase subunit IV as substrate
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Aldehyde dehydrogenase precursor peptide
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cytochrome c oxidase subunit IV as substrate
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antisense RNA
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transformants expressing the anti-sense RNA of the beta subunit of MPP: beta subunit of MPP protein increases about 1.8-fold relative to the wild type, and its mRNA increases 4.5-fold, expression of alpha subunit also increases. Results indicate that expression is induced by the antisense RNA of the MPP's beta subunit gene
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IAA
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affects specifically MPP, less effective than NEM or PCMB, dithioerythritol protects
iodoacetic acid
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affects specifically MPP, less effective than NEM or PCMB, dithioerythritol protects
Linker-deleted aldehyde dehydrogenase signal peptide
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weak, cytochrome c oxidase subunit IV as substrate
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Peptide pb2(15-34)
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derived from prepeptide of cytochrome b2 peptide pb2(1-31)
Peptide pF1beta(1-18)
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derived from prepeptide of beta-subunit of F1-ATP-synthase, much less effective than pF1beta(38-54), N-terminal presequence
Peptide pF1beta(38-54)
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derived from prepeptide of beta-subunit of F1-ATP-synthase, C-terminal presequence
Prepeptide p25
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derived from amino terminal of cytochrome oxidase subunit IV precursor, kinetics
Prepeptide p34
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derived from amino terminal of cytochrome oxidase subunit IV precursor, kinetics
Prepeptide pF1beta(1-32)
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derived from beta-subunit of F1-ATPase presequence
1,10-phenanthroline
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excess Co2+ (rat) restores; excess Mn2+ (bovine, rat) restores
1,10-phenanthroline
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excess Zn2+ or Co2+ partially restores; soluble matrix enzyme
1,10-phenanthroline
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excess Zn2+ or Co2+ partially restores; in vitro and in vivo
EDTA
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excess Co2+ restores; excess Mn2+ restores; excess Zn2+, Co2+ partially restores
GTP
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soluble matrix enzyme; Zn2+ or Co2+ in excess partially restores
o-phenanthroline
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enzyme inhibition leads to degradation of the unprocessed preproteins in the mitochondrial matrix space
o-phenanthroline
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enzyme inhibition leads to degradation of the unprocessed preproteins in the mitochondrial matrix space
additional information
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antimycin, phenylmethylsulfonyl fluoride, hemin, pepstatin, and N-ethylmaleimide are no inhibitors
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additional information
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chicken cystatin; epoxysuccinyl-leucyl agmatine from Aspergillus japonicum (i.e. E-64)
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additional information
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glucagon, bovine serum albumin, rabbit reticulocyte lysate
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additional information
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isolated from dog; no inhibition by chymotryptic inhibitors; no inhibition by leupeptin or pepstatin; no inhibition by serine protease inhibitors, e.g. antipain, chymostatin; no inhibition by tryptic inhibitors; pancreas, chicken egg white or soybean
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additional information
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4-aminobenzamidine; tosyl-Lys chloromethyl ketone, tosyl-Phe chloromethyl ketone
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additional information
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4-aminobenzamidine; diisopropyl fluoride; isolated from bovine; no inhibition by leupeptin or pepstatin; no inhibition by serine protease inhibitors, e.g. antipain, chymostatin; no inhibition by tryptic inhibitors; pancreas, chicken egg white or soybean; PMSF
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additional information
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bestatin; no inhibition by leupeptin or pepstatin; PMSF
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additional information
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epoxysuccinyl-leucyl agmatine from Aspergillus japonicum (i.e. E-64); no inhibition by antimycin A, myxothiazol; no inhibition by leupeptin or pepstatin; PMSF
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additional information
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bestatin; no inhibition by leupeptin or pepstatin; PMSF
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additional information
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arginine, synthetic helical 22 amino acid peptide derived from heparin-binding domain of antithrombin III (ATIII); pF1beta(51-54), pF1beta(49-54) or pF1beta(44-54)
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