3.4.24.61: nardilysin

This is an abbreviated version!
For detailed information about nardilysin, go to the full flat file.

Reaction

hydrolysis of polypeptides, preferably at -Xaa-/-Arg-Lys-, and less commonly at -Arg-/-Arg-Xaa-, in which Xaa is not Arg or Lys =

Synonyms

hNRDc1, MGE, miniglucagon-generating endopeptidase, More, N-arginine dibasic (NRD) convertase, N-Arginine dibasic convertase, nardilysin, nardilysin (V8), nardilysin convertase, NRD convertase, NRD-convertase, Nrd1, Nrd1 and NRDc, NRDc

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.24 Metalloendopeptidases

                3.4.24.61 nardilysin

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Results	in table
2	Activating Compound
34	AA Sequence
3	Application
2	CAS Registry Number
9	Cloned(Commentary)
125	Disease/ Diagnostics
4	Expression
20	General Information
50	Inhibitors
92	KM Value [mM]
20	Localization
15	Metals/Ions
17	Molecular Weight [Da]
18	Natural Substrates/ Products (Substrates)
40	Organism
7	pH Optimum
4	pH Range
1	pH Stability
12	Protein Variants
10	Purification (Commentary)
1	Reaction
1	Reaction Type
40	Reference
50	Source Tissue
172	Substrates and Products (Substrate)
7	Subunits
55	Synonyms
5	Temperature Optimum [°C]
1	Temperature Stability [°C]
66	Turnover Number [1/s]

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Turnover Number on EC 3.4.24.61 - nardilysin

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TURNOVER NUMBER [1/s]

SUBSTRATE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

0.031 - 7.68

2-aminobenzoyl-GFSPFRSSRQED(2,4-dinitrophenyl)

2 entries

3.88

2-aminobenzoyl-GGALRKVGQ-ethylenediamine-2,4-dinitrophenyl

Rattus norvegicus

-

pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGXLRKVGQ-ethylenediamine-2,4-dinitrophenyl

652006

1.08

2-aminobenzoyl-GGFARKVGQ-ethylenediamine-2,4-dinitrophenyl

Rattus norvegicus

-

pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGFXRKVGQ-ethylenediamine-2,4-dinitrophenyl

652006

2.83

2-aminobenzoyl-GGFFRKVGQ-ethylenediamine-2,4-dinitrophenyl

Rattus norvegicus

-

pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGFXRKVGQ-ethylenediamine-2,4-dinitrophenyl

652006

6.9

2-aminobenzoyl-GGFHRKVGQ-ethylenediamine-2,4-dinitrophenyl

Rattus norvegicus

-

pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGFXRKVGQ-ethylenediamine-2,4-dinitrophenyl

652006

0.198

2-aminobenzoyl-GGFIKKVGQ-ethylenediamine-2,4-dinitrophenyl

Rattus norvegicus

-

pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGFIXXVGQ-ethylenediamine-2,4-dinitrophenyl

652006

12.09

2-aminobenzoyl-GGFIKRVGQ-ethylenediamine-2,4-dinitrophenyl

Rattus norvegicus

-

pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGFIXXVGQ-ethylenediamine-2,4-dinitrophenyl

652006

1.22 - 1.23

2-aminobenzoyl-GGFIRKVGQ-ethylenediamine-2,4-dinitrophenyl

2 entries

15.73

2-aminobenzoyl-GGFIRRVGQ-ethylenediamine-2,4-dinitrophenyl

Rattus norvegicus

-

pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGFIXXVGQ-ethylenediamine-2,4-dinitrophenyl

652006

3.3 - 5.03

2-aminobenzoyl-GGFIRRVGQ-N-(2,4-dinitrophenyl)ethylenediamine

2 entries

2.16

2-aminobenzoyl-GGFLKKVGQ-ethylenediamine-2,4-dinitrophenyl

Rattus norvegicus

-

pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGFLXXVGQ-ethylenediamine-2,4-dinitrophenyl

652006

9.75

2-aminobenzoyl-GGFLKRVGQ-ethylenediamine-2,4-dinitrophenyl

Rattus norvegicus

-

pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGFLXXVGQ-ethylenediamine-2,4-dinitrophenyl

652006

2.04

2-aminobenzoyl-GGFLRKAGQ-ethylenediamine-2,4-dinitrophenyl

Rattus norvegicus

-

pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGFLRKXGQ-ethylenediamine-2,4-dinitrophenyl

652006

0.24

2-aminobenzoyl-GGFLRKDGQ-ethylenediamine-2,4-dinitrophenyl

Rattus norvegicus

-

pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGFLRKXGQ-ethylenediamine-2,4-dinitrophenyl

652006

2.94

2-aminobenzoyl-GGFLRKFGQ-ethylenediamine-2,4-dinitrophenyl

Rattus norvegicus

-

pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGFLRKXGQ-ethylenediamine-2,4-dinitrophenyl

652006

13.69

2-aminobenzoyl-GGFLRKHGQ-ethylenediamine-2,4-dinitrophenyl

Rattus norvegicus

-

pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGFLRKXGQ-ethylenediamine-2,4-dinitrophenyl

652006

2.04

2-aminobenzoyl-GGFLRKIGQ-ethylenediamine-2,4-dinitrophenyl

Rattus norvegicus

-

pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGFLRKXGQ-ethylenediamine-2,4-dinitrophenyl

652006

1.74

2-aminobenzoyl-GGFLRKLGQ-ethylenediamine-2,4-dinitrophenyl

Rattus norvegicus

-

pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGFLRKXGQ-ethylenediamine-2,4-dinitrophenyl

652006

2.77

2-aminobenzoyl-GGFLRKMGQ-ethylenediamine-2,4-dinitrophenyl

Rattus norvegicus

-

pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGFLRKXGQ-ethylenediamine-2,4-dinitrophenyl

652006

1.59

2-aminobenzoyl-GGFLRKNGQ-ethylenediamine-2,4-dinitrophenyl

Rattus norvegicus

-

pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGFLRKXGQ-ethylenediamine-2,4-dinitrophenyl

652006

4.65

2-aminobenzoyl-GGFLRKSGQ-ethylenediamine-2,4-dinitrophenyl

Rattus norvegicus

-

pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGFLRKXGQ-ethylenediamine-2,4-dinitrophenyl

652006

2.48

2-aminobenzoyl-GGFLRKVGQ-ethylenediamine-2,4-dinitrophenyl

Rattus norvegicus

-

pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGFXRKVGQ-ethylenediamine-2,4-dinitrophenyl and hydrolysis of the peptide series 2-aminobenzoyl-GGFLRKXGQ-ethylenediamine-2,4-dinitrophenyl and hydrolysis of the peptide series 2-aminobenzoyl-GGXLRKVGQ-ethylenediamine-2,4-dinitrophenyl and hydrolysis of the peptide series 2-aminobenzoyl-GGFLXXVGQ-ethylenediamine-2,4-dinitrophenyl

652006

5.61

2-aminobenzoyl-GGFLRKWGQ-ethylenediamine-2,4-dinitrophenyl

Rattus norvegicus

-

pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGFLRKXGQ-ethylenediamine-2,4-dinitrophenyl

652006

9.92

2-aminobenzoyl-GGFLRRVGQ-ethylenediamine-2,4-dinitrophenyl

Rattus norvegicus

-

pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGFLXXVGQ-ethylenediamine-2,4-dinitrophenyl

652006

4.86

2-aminobenzoyl-GGFMRKVGQ-ethylenediamine-2,4-dinitrophenyl

Rattus norvegicus

-

pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGFXRKVGQ-ethylenediamine-2,4-dinitrophenyl

652006

1.08

2-aminobenzoyl-GGFNRKVGQ-ethylenediamine-2,4-dinitrophenyl

Rattus norvegicus

-

pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGFXRKVGQ-ethylenediamine-2,4-dinitrophenyl

652006

0.353

2-aminobenzoyl-GGFSRKVGQ-ethylenediamine-2,4-dinitrophenyl

Rattus norvegicus

-

pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGFXRKVGQ-ethylenediamine-2,4-dinitrophenyl

652006

0.41

2-aminobenzoyl-GGFVRKVGQ-ethylenediamine-2,4-dinitrophenyl

Rattus norvegicus

-

pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGFXRKVGQ-ethylenediamine-2,4-dinitrophenyl

652006

0.705

2-aminobenzoyl-GGFWRKVGQ-ethylenediamine-2,4-dinitrophenyl

Rattus norvegicus

-

pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGFXRKVGQ-ethylenediamine-2,4-dinitrophenyl

652006

0.187

2-aminobenzoyl-GGFYKKVGQ-ethylenediamine-2,4-dinitrophenyl

Rattus norvegicus

-

pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGFYXXVGQ-ethylenediamine-2,4-dinitrophenyl

652006

0.405

2-aminobenzoyl-GGFYKRVGQ-ethylenediamine-2,4-dinitrophenyl

Rattus norvegicus

-

pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGFYXXVGQ-ethylenediamine-2,4-dinitrophenyl

652006

2.59 - 2.63

2-aminobenzoyl-GGFYRKVGQ-ethylenediamine-2,4-dinitrophenyl

2 entries

18.99

2-aminobenzoyl-GGFYRRVGQ-ethylenediamine-2,4-dinitrophenyl

Rattus norvegicus

-

pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGFYXXVGQ-ethylenediamine-2,4-dinitrophenyl

652006

4.36

2-aminobenzoyl-GGHLRKVGQ-ethylenediamine-2,4-dinitrophenyl

Rattus norvegicus

-

pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGXLRKVGQ-ethylenediamine-2,4-dinitrophenyl

652006

4.84

2-aminobenzoyl-GGILRKVGQ-ethylenediamine-2,4-dinitrophenyl

Rattus norvegicus

-

pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGXLRKVGQ-ethylenediamine-2,4-dinitrophenyl

652006

5.83

2-aminobenzoyl-GGLLRKVGQ-ethylenediamine-2,4-dinitrophenyl

Rattus norvegicus

-

pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGXLRKVGQ-ethylenediamine-2,4-dinitrophenyl

652006

7.84

2-aminobenzoyl-GGMLRKVGQ-ethylenediamine-2,4-dinitrophenyl

Rattus norvegicus

-

pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGXLRKVGQ-ethylenediamine-2,4-dinitrophenyl

652006

0.953

2-aminobenzoyl-GGNLRKVGQ-ethylenediamine-2,4-dinitrophenyl

Rattus norvegicus

-

pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGXLRKVGQ-ethylenediamine-2,4-dinitrophenyl

652006

8.53

2-aminobenzoyl-GGSLRKVGQ-ethylenediamine-2,4-dinitrophenyl

Rattus norvegicus

-

pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGXLRKVGQ-ethylenediamine-2,4-dinitrophenyl

652006

3.24

2-aminobenzoyl-GGVLRKVGQ-ethylenediamine-2,4-dinitrophenyl

Rattus norvegicus

-

pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGXLRKVGQ-ethylenediamine-2,4-dinitrophenyl

652006

4.95

2-aminobenzoyl-GGWLRKVGQ-ethylenediamine-2,4-dinitrophenyl

Rattus norvegicus

-

pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGXLRKVGQ-ethylenediamine-2,4-dinitrophenyl

652006

1.85

2-aminobenzoyl-GGYLRKVGQ-ethylenediamine-2,4-dinitrophenyl

Rattus norvegicus

-

pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGXLRKVGQ-ethylenediamine-2,4-dinitrophenyl

652006

0.04 - 9.48

2-aminobenzoyl-MISLMKRPQED(2,4-dinitrophenyl)

2 entries

0.216 - 6.08

2-aminobenzoyl-TPLVTLX1X2NAIIKQED(2,4-dinitrophenyl)

10 entries

3.3 - 5.03

beta-endorphin

2 entries

1.81 - 2.94

calcitonin

2 entries

0.783 - 6.08

Somatostatin-14

3 entries

additional information

2-aminobenzoyl-MISLMKRPPGFSPFRSSRI-NH2

Mus musculus

-

pH 7.0, 37°C

650203

0.031 - 0.51

2-aminobenzoyl-GFSPFRSSRQED(2,4-dinitrophenyl)

Mus musculus

-

pH 7.0, 37°C

650203

7.68

2-aminobenzoyl-GFSPFRSSRQED(2,4-dinitrophenyl)

Mus musculus

-

pH 7.0, 37°C

650203

1.22

2-aminobenzoyl-GGFIRKVGQ-ethylenediamine-2,4-dinitrophenyl

Rattus norvegicus

-

pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGFXRKVGQ-ethylenediamine-2,4-dinitrophenyl

652006

1.23

2-aminobenzoyl-GGFIRKVGQ-ethylenediamine-2,4-dinitrophenyl

Rattus norvegicus

-

pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGFIXXVGQ-ethylenediamine-2,4-dinitrophenyl

652006

3.3

2-aminobenzoyl-GGFIRRVGQ-N-(2,4-dinitrophenyl)ethylenediamine

Mus musculus

-

pH 7.0, 37°C

650203

5.03

2-aminobenzoyl-GGFIRRVGQ-N-(2,4-dinitrophenyl)ethylenediamine

Mus musculus

-

pH 7.0, 37°C

650203

2.59

2-aminobenzoyl-GGFYRKVGQ-ethylenediamine-2,4-dinitrophenyl

Rattus norvegicus

-

pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGFXRKVGQ-ethylenediamine-2,4-dinitrophenyl and hydrolysis of the peptide series 2-aminobenzoyl-GGFLXXVGQ-ethylenediamine-2,4-dinitrophenyl

652006

2.63

2-aminobenzoyl-GGFYRKVGQ-ethylenediamine-2,4-dinitrophenyl

Rattus norvegicus

-

pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGFYXXVGQ-ethylenediamine-2,4-dinitrophenyl

652006

0.04 - 1.97

2-aminobenzoyl-MISLMKRPQED(2,4-dinitrophenyl)

Mus musculus

-

pH 7.0, 37°C

650203

9.48

2-aminobenzoyl-MISLMKRPQED(2,4-dinitrophenyl)

Mus musculus

-

pH 7.0, 37°C

650203

0.216

2-aminobenzoyl-TPLVTLX1X2NAIIKQED(2,4-dinitrophenyl)

Mus musculus

-

pH 7.0, 37°C, LK

650203

0.455

2-aminobenzoyl-TPLVTLX1X2NAIIKQED(2,4-dinitrophenyl)

Mus musculus

-

pH 7.0, 37°C, WK and MK

650203

0.498

2-aminobenzoyl-TPLVTLX1X2NAIIKQED(2,4-dinitrophenyl)

Mus musculus

-

pH 7.0, 37°C, KK

650203

0.628

2-aminobenzoyl-TPLVTLX1X2NAIIKQED(2,4-dinitrophenyl)

Mus musculus

-

pH 7.0, 37°C, FK

650203

0.693

2-aminobenzoyl-TPLVTLX1X2NAIIKQED(2,4-dinitrophenyl)

Mus musculus

-

pH 7.0, 37°C, RK

650203

0.78

2-aminobenzoyl-TPLVTLX1X2NAIIKQED(2,4-dinitrophenyl)

Mus musculus

-

pH 7.0, 37°C, YK

650203

6.08

2-aminobenzoyl-TPLVTLX1X2NAIIKQED(2,4-dinitrophenyl)

Mus musculus

-

pH 7.0, 37°C, FK

650203

6.08

2-aminobenzoyl-TPLVTLX1X2NAIIKQED(2,4-dinitrophenyl)

Mus musculus

-

pH 7.0, 37°C, FR

650203

6.08

2-aminobenzoyl-TPLVTLX1X2NAIIKQED(2,4-dinitrophenyl)

Mus musculus

-

pH 7.0, 37°C, RK

650203

6.08

2-aminobenzoyl-TPLVTLX1X2NAIIKQED(2,4-dinitrophenyl)

Mus musculus

-

pH 7.0, 37°C, YK

650203

3.3

beta-endorphin

Mus musculus

-

pH 7.0, 37°C

650203

5.03

beta-endorphin

Mus musculus

-

pH 7.0, 37°C

650203

1.81

calcitonin

Mus musculus

-

pH 7.0, 37°C

650203

2.94

calcitonin

Mus musculus

-

pH 7.0, 37°C

650203

0.783

Somatostatin-14

Mus musculus

-

pH 7.0, 37°C

650203

0.95

Somatostatin-14

Mus musculus

-

pH 7.0, 37°C, reduced somatostatin

650203

6.08

Somatostatin-14

Mus musculus

-

pH 7.0, 37°C

650203