3.4.24.61: nardilysin
This is an abbreviated version!
For detailed information about nardilysin, go to the full flat file.
Word Map on EC 3.4.24.61
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3.4.24.61
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metalloendopeptidase
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ectodomain
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heparin-binding
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pitrilysins
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adam17
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hb-egf
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insulysin
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insulinase
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hxxeh
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dynorphins
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medicine
- 3.4.24.61
- metalloendopeptidase
- ectodomain
-
heparin-binding
- pitrilysins
- adam17
- hb-egf
- insulysin
- insulinase
-
hxxeh
- dynorphins
- medicine
Reaction
hydrolysis of polypeptides, preferably at -Xaa-/-Arg-Lys-, and less commonly at -Arg-/-Arg-Xaa-, in which Xaa is not Arg or Lys =
Synonyms
hNRDc1, MGE, miniglucagon-generating endopeptidase, More, N-arginine dibasic (NRD) convertase, N-Arginine dibasic convertase, nardilysin, nardilysin (V8), nardilysin convertase, NRD convertase, NRD-convertase, Nrd1, Nrd1 and NRDc, NRDc
ECTree
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Subunits
Subunits on EC 3.4.24.61 - nardilysin
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additional information
interaction of enzyme with tumor necrosis factor-alpha-converting enzyme
additional information
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miniglucagon-generating endopeptidase is composed of N-arginine dibasic convertase and aminopeptidase B, acting sequentially
additional information
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enzyme interacts with its acidic domain with mitochondrial malate dehydrogenase and citrate synthase. Mitochondrial malate dehydrogenase increases enzyme activity by 50%, while enzyme stabilizes mitochondrial malate dehydrogenase towards heat inactivation
additional information
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interaction of brain-specific protein p42IP4/centaurin-alpha1 and its homologue centaurin-alpha2 with acidic domain of enzyme. Preincubation of p42IP4 with its cognate ligands D-inositol(1,3,4,5)tetrakisphosphate and diC8-phosphatidylinositol 3,4,5-trisphosphate negatively modultes interaction
additional information
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miniglucagon-generating endopeptidase is composed of N-arginine dibasic convertase and aminopeptidase B, acting sequentially