3.4.24.61: nardilysin
This is an abbreviated version!
For detailed information about nardilysin, go to the full flat file.
Word Map on EC 3.4.24.61
-
3.4.24.61
-
metalloendopeptidase
-
ectodomain
-
heparin-binding
-
pitrilysins
-
adam17
-
hb-egf
-
insulysin
-
insulinase
-
hxxeh
-
dynorphins
-
medicine
- 3.4.24.61
- metalloendopeptidase
- ectodomain
-
heparin-binding
- pitrilysins
- adam17
- hb-egf
- insulysin
- insulinase
-
hxxeh
- dynorphins
- medicine
Reaction
hydrolysis of polypeptides, preferably at -Xaa-/-Arg-Lys-, and less commonly at -Arg-/-Arg-Xaa-, in which Xaa is not Arg or Lys =
Synonyms
hNRDc1, MGE, miniglucagon-generating endopeptidase, More, N-arginine dibasic (NRD) convertase, N-Arginine dibasic convertase, nardilysin, nardilysin (V8), nardilysin convertase, NRD convertase, NRD-convertase, Nrd1, Nrd1 and NRDc, NRDc
ECTree
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Substrates Products
Substrates Products on EC 3.4.24.61 - nardilysin
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REACTION DIAGRAM
2-aminobenzoyl-GGALRKVGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGA + LRKVGQ-ethylenediamine-2,4-dinitrophenyl
-
percentage cleaved 24% at AL and 76% at RK
-
-
?
2-aminobenzoyl-GGALRKVGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGALR + KVGQ-ethylenediamine-2,4-dinitrophenyl
-
percentage cleaved 24% at AL and 76% at RK
-
-
?
2-aminobenzoyl-GGFARKVGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGFA + RKVGQ-ethylenediamine-2,4-dinitrophenyl
-
percentage cleaved 65% at AR and 35% at RK
-
-
?
2-aminobenzoyl-GGFARKVGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGFAR + KVGQ-ethylenediamine-2,4-dinitrophenyl
-
percentage cleaved 65% at AR and 35% at RK
-
-
?
2-aminobenzoyl-GGFFRKVGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGFF + RKVGQ-ethylenediamine-2,4-dinitrophenyl
-
percentage cleaved 100% at FR
-
-
?
2-aminobenzoyl-GGFHRKVGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGFH + RKVGQ-ethylenediamine-2,4-dinitrophenyl
-
percentage cleaved 100% at HR
-
-
?
2-aminobenzoyl-GGFIKKVGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGFIK + KVGQ-ethylenediamine-2,4-dinitrophenyl
-
percentage cleaved 0% at IK and 100% at KK
-
-
?
2-aminobenzoyl-GGFIKRVGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGFIK + RVGQ-ethylenediamine-2,4-dinitrophenyl
-
percentage cleaved 0% at IK and 100% at KR
-
-
?
2-aminobenzoyl-GGFIRKVGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGFIR + KVGQ-ethylenediamine-2,4-dinitrophenyl
2-aminobenzoyl-GGFIRRVGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGFIR + RVGQ-ethylenediamine-2,4-dinitrophenyl
-
percentage cleaved 0% at IR and 100% at RR
-
-
?
2-aminobenzoyl-GGFLKKVGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGFL + KKVGQ-ethylenediamine-2,4-dinitrophenyl
-
percentage cleaved 5% at LL and 95% at KK
-
-
?
2-aminobenzoyl-GGFLKKVGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGFLK + KVGQ-ethylenediamine-2,4-dinitrophenyl
-
percentage cleaved 5% at LL and 95% at KK
-
-
?
2-aminobenzoyl-GGFLKRVGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGFL + KRVGQ-ethylenediamine-2,4-dinitrophenyl
-
percentage cleaved 1% at LK and 99% at KR
-
-
?
2-aminobenzoyl-GGFLKRVGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGFLK + RVGQ-ethylenediamine-2,4-dinitrophenyl
-
percentage cleaved 1% at LK and 99% at KR
-
-
?
2-aminobenzoyl-GGFLRKAGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGFLR + KAGQ-ethylenediamine-2,4-dinitrophenyl
-
percentage cleaved 25% at KA and 75% at RK
-
-
?
2-aminobenzoyl-GGFLRKAGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGFLRK + AGQ-ethylenediamine-2,4-dinitrophenyl
-
percentage cleaved 25% at KA and 75% at RK
-
-
?
2-aminobenzoyl-GGFLRKDGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGFLR + KDGQ-ethylenediamine-2,4-dinitrophenyl
-
percentage cleaved 23% at KD and 77% at RK
-
-
?
2-aminobenzoyl-GGFLRKDGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGFLRK + DGQ-ethylenediamine-2,4-dinitrophenyl
-
percentage cleaved 23% at KD and 77% at RK
-
-
?
2-aminobenzoyl-GGFLRKFGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGFLR + KFGQ-ethylenediamine-2,4-dinitrophenyl
-
percentage cleaved 17% at KF and 83% at RK
-
-
?
2-aminobenzoyl-GGFLRKFGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGFLRK + FGQ-ethylenediamine-2,4-dinitrophenyl
-
percentage cleaved 17% at KF and 83% at RK
-
-
?
2-aminobenzoyl-GGFLRKHGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGFLR + KHGQ-ethylenediamine-2,4-dinitrophenyl
-
percentage cleaved 10% at KH and 90% at RK
-
-
?
2-aminobenzoyl-GGFLRKHGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGFLRK + HGQ-ethylenediamine-2,4-dinitrophenyl
-
percentage cleaved 10% at KH and 90% at RK
-
-
?
2-aminobenzoyl-GGFLRKIGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGFLR + KIGQ-ethylenediamine-2,4-dinitrophenyl
-
percentage cleaved 19% at KI and 81% at RK
-
-
?
2-aminobenzoyl-GGFLRKIGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGFLRK + IGQ-ethylenediamine-2,4-dinitrophenyl
-
percentage cleaved 19% at KI and 81% at RK
-
-
?
2-aminobenzoyl-GGFLRKLGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGFLR + KLGQ-ethylenediamine-2,4-dinitrophenyl
-
percentage cleaved 26% at KL and 74% at RK
-
-
?
2-aminobenzoyl-GGFLRKLGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGFLRK + LGQ-ethylenediamine-2,4-dinitrophenyl
-
percentage cleaved 26% at KL and 74% at RK
-
-
?
2-aminobenzoyl-GGFLRKMGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGFLR + KMGQ-ethylenediamine-2,4-dinitrophenyl
-
percentage cleaved 14% at KM and 86% at RK
-
-
?
2-aminobenzoyl-GGFLRKMGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGFLRK + MGQ-ethylenediamine-2,4-dinitrophenyl
-
percentage cleaved 14% at KM and 86% at RK
-
-
?
2-aminobenzoyl-GGFLRKNGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGFLR + KNGQ-ethylenediamine-2,4-dinitrophenyl
-
percentage cleaved 24% at KN and 76% at RK
-
-
?
2-aminobenzoyl-GGFLRKNGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGFLRK + NGQ-ethylenediamine-2,4-dinitrophenyl
-
percentage cleaved 24% at KN and 76% at RK
-
-
?
2-aminobenzoyl-GGFLRKSGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGFLR + KSGQ-ethylenediamine-2,4-dinitrophenyl
-
percentage cleaved 25% at KS and 75% at RK
-
-
?
2-aminobenzoyl-GGFLRKSGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGFLRK + SGQ-ethylenediamine-2,4-dinitrophenyl
-
percentage cleaved 25% at KS and 75% at RK
-
-
?
2-aminobenzoyl-GGFLRKVGQ-(N-2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-GGFL + RKVGQ-(N-2,4-dinitrophenyl)ethylenediamine
-
percentage cleaved 23% at LR and 77% at RK
-
-
?
2-aminobenzoyl-GGFLRKVGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGF + LRKVGQ-ethylenediamine-2,4-dinitrophenyl
-
percentage cleaved 23% at FL and 77% at RK
-
-
?
2-aminobenzoyl-GGFLRKVGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGFL + RKVGQ-ethylenediamine-2,4-dinitrophenyl
-
percentage cleaved 23% at LR and 77% at RK
-
-
?
2-aminobenzoyl-GGFLRKVGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGFLR + KVGQ-ethylenediamine-2,4-dinitrophenyl
2-aminobenzoyl-GGFLRKVGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGFLRK + VGQ-ethylenediamine-2,4-dinitrophenyl
-
percentage cleaved 23% at KV and 77% at RK
-
-
?
2-aminobenzoyl-GGFLRKWGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGFLR + KWGQ-ethylenediamine-2,4-dinitrophenyl
-
percentage cleaved 13% at KW and 87% at RK
-
-
?
2-aminobenzoyl-GGFLRKWGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGFLRK + WGQ-ethylenediamine-2,4-dinitrophenyl
-
percentage cleaved 13% at KW and 87% at RK
-
-
?
2-aminobenzoyl-GGFLRRVGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGFL + RRVGQ-ethylenediamine-2,4-dinitrophenyl
-
percentage cleaved 7% at LR and 93% at RR
-
-
?
2-aminobenzoyl-GGFLRRVGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGFLR + RVGQ-ethylenediamine-2,4-dinitrophenyl
-
percentage cleaved 7% at LR and 93% at RR
-
-
?
2-aminobenzoyl-GGFLRRVGQ-N[2,4-dinitrophenyl]-ethylenediamine + H2O
?
-
-
-
?
2-aminobenzoyl-GGFMRKVGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGFM + RKVGQ-ethylenediamine-2,4-dinitrophenyl
-
percentage cleaved 29% at MR and 71% at RK
-
-
?
2-aminobenzoyl-GGFMRKVGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGFMR + KVGQ-ethylenediamine-2,4-dinitrophenyl
-
percentage cleaved 29% at MR and 71% at RK
-
-
?
2-aminobenzoyl-GGFNRKVGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGFN + RKVGQ-ethylenediamine-2,4-dinitrophenyl
-
percentage cleaved 100% at NR
-
-
?
2-aminobenzoyl-GGFSRKVGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGFS + RKVGQ-ethylenediamine-2,4-dinitrophenyl
-
percentage cleaved 76% at SR and 24% at RK
-
-
?
2-aminobenzoyl-GGFSRKVGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGFSR + KVGQ-ethylenediamine-2,4-dinitrophenyl
-
percentage cleaved 76% at SR and 24% at RK
-
-
?
2-aminobenzoyl-GGFVRKVGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGFVR + KVGQ-ethylenediamine-2,4-dinitrophenyl
-
percentage cleaved 100% at RK
-
-
?
2-aminobenzoyl-GGFWRKVGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGFW + RKVGQ-ethylenediamine-2,4-dinitrophenyl
-
percentage cleaved 100% at WR
-
-
?
2-aminobenzoyl-GGFYKKVGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGFYKKVGQ-ethylenediamine-2,4-dinitrophenyl
-
percentage cleaved 100% at YK and 0% at KK
-
-
?
2-aminobenzoyl-GGFYKRVGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGFY + KRVGQ-ethylenediamine-2,4-dinitrophenyl
-
percentage cleaved 64% at YK and 36% at KR
-
-
?
2-aminobenzoyl-GGFYKRVGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGFYK + RVGQ-ethylenediamine-2,4-dinitrophenyl
-
percentage cleaved 64% at YK and 36% at KR
-
-
?
2-aminobenzoyl-GGFYRKVGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGFY + RKVGQ-ethylenediamine-2,4-dinitrophenyl
2-aminobenzoyl-GGFYRRVGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGFY + RRVGQ-ethylenediamine-2,4-dinitrophenyl
-
percentage cleaved 65% at YR and 35% at RR
-
-
?
2-aminobenzoyl-GGFYRRVGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGFYR + RVGQ-ethylenediamine-2,4-dinitrophenyl
-
percentage cleaved 65% at YR and 35% at RR
-
-
?
2-aminobenzoyl-GGHLRKVGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGH + LRKVGQ-ethylenediamine-2,4-dinitrophenyl
-
percentage cleaved 26% at HL and 74% at RK
-
-
?
2-aminobenzoyl-GGHLRKVGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGHLR + KVGQ-ethylenediamine-2,4-dinitrophenyl
-
percentage cleaved 26% at HL and 74% at RK
-
-
?
2-aminobenzoyl-GGILRKVGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGI + LRKVGQ-ethylenediamine-2,4-dinitrophenyl
-
percentage cleaved 56% at IL and 44% at RK
-
-
?
2-aminobenzoyl-GGILRKVGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGILR + KVGQ-ethylenediamine-2,4-dinitrophenyl
-
percentage cleaved 56% at IL and 44% at RK
-
-
?
2-aminobenzoyl-GGLLRKVGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGL + LRKVGQ-ethylenediamine-2,4-dinitrophenyl
-
percentage cleaved 73% at LL and 27% at RK
-
-
?
2-aminobenzoyl-GGLLRKVGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGLLR + KVGQ-ethylenediamine-2,4-dinitrophenyl
-
percentage cleaved 73% at LL and 27% at RK
-
-
?
2-aminobenzoyl-GGMLRKVGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGM + LRKVGQ-ethylenediamine-2,4-dinitrophenyl
-
percentage cleaved 81% at ML and 19% at RK
-
-
?
2-aminobenzoyl-GGMLRKVGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGMLR + KVGQ-ethylenediamine-2,4-dinitrophenyl
-
percentage cleaved 81% at ML and 19% at RK
-
-
?
2-aminobenzoyl-GGNLRKVGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGN + LRKVGQ-ethylenediamine-2,4-dinitrophenyl
-
percentage cleaved 23% at NL and 77% at RK
-
-
?
2-aminobenzoyl-GGNLRKVGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGNLR + KVGQ-ethylenediamine-2,4-dinitrophenyl
-
percentage cleaved 23% at NL and 77% at RK
-
-
?
2-aminobenzoyl-GGSLRKVGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGS + LRKVGQ-ethylenediamine-2,4-dinitrophenyl
-
percentage cleaved 4% at SL and 96% at RK
-
-
?
2-aminobenzoyl-GGSLRKVGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGSLR + KVGQ-ethylenediamine-2,4-dinitrophenyl
-
percentage cleaved 4% at SL and 96% at RK
-
-
?
2-aminobenzoyl-GGVLRKVGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGV + LRKVGQ-ethylenediamine-2,4-dinitrophenyl
-
percentage cleaved 19% at VL and 81% at RK
-
-
?
2-aminobenzoyl-GGVLRKVGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGVLR + KVGQ-ethylenediamine-2,4-dinitrophenyl
-
percentage cleaved 19% at VL and 81% at RK
-
-
?
2-aminobenzoyl-GGWLRKVGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGW + LRKVGQ-ethylenediamine-2,4-dinitrophenyl
-
percentage cleaved 18% at WL and 82% at RK
-
-
?
2-aminobenzoyl-GGWLRKVGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGWLR + KVGQ-ethylenediamine-2,4-dinitrophenyl
-
percentage cleaved 18% at WL and 82% at RK
-
-
?
2-aminobenzoyl-GGYLRKVGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGY + LRKVGQ-ethylenediamine-2,4-dinitrophenyl
-
percentage cleaved 2% at YL and 98% at RK
-
-
?
2-aminobenzoyl-GGYLRKVGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGYLR + KVGQ-ethylenediamine-2,4-dinitrophenyl
-
percentage cleaved 2% at YL and 98% at RK
-
-
?
2-aminobenzoyl-MISLMKRPPGFSPFRSSRI-NH2 + H2O
desArg10 kallidin (KRPPGFSPF) + ?
-
kallidin model peptide, nardilysin does not release desArg10 kallidin from the physiological precursor low molecular weight kiniogen
-
?
2-aminobenzoyl-TPLVTLX1X2NAIIKQED(2,4-dinitrophenyl) + H2O
?
-
fluorogenic substrate based on beta-endorphin, nardilysin hydrolyzes peptides when X1-X2 are F-K, F-R, W-K, M-K,Y-K, or L-K, K-F is not hydrolyzed
-
?
amyloid precursor protein + H2O
?
the enzyme enhances alpha-cleavage of amyloid precursor protein, which results in the decreased generation of amyloid beta in vitro
-
-
?
ANF-(1-28) + H2O
?
-
i.e. atrial natriuretic factor, cleavage site: Arg+Arg
-
-
?
beta-endorphin + H2O
Tyr-Gly-Gly-Phe-Met-Thr-Ser-Glu-Lys-Ser-Gln-Thr-Pro-Leu-Val-Thr-Leu-Phe + Lys-Asn-Ala-Ile-Ile-Lys-Asn-Ala-Tyr-Lys-Lys-Gly-Gln + ?
-
-
-
?
Bovine adrenal medulla dodecapeptide + H2O
Tyr-Gly-Gly-Phe-Met-Arg + Arg-Val-Gly-Arg-Pro-Glu
dynorphin A + H2O
Tyr-Gly-Gly-Phe-Leu-Arg + Arg-Ile-Arg-Pro-Lys-Leu-Lys-Trp-Asp-Asn-Gln-NH2
heparin-binding epidermal growth factor-like growth factor + H2O
?
substrate is synthesized as a transmembrane protein. Enzyme enhances ectodomain shedding of substrate in coperation with tumor necrosis factor-alpha-converting enzyme. Metalloendopeptidase activity of enzyme is not required for enhancement of shedding
-
-
?
peptide I + H2O
Pro-Arg-Glu-Arg-Lys + Ala-Gly-Ala-Lys-Asn-Tyr-NH2
-
i.e. Pro-Arg-Glu-Arg-Lys-Ala-Gly-Ala-Lys-Asn125I-Tyr-NH2
i.e. peptide II
?
Peptide III + H2O
Pro-Arg-Glu-Arg + Arg-Ala-Gly-Ala-Lys-Asn-Tyr-NH2
-
i.e. Pro-Arg-Glu-Arg-Arg-Ala-Gly-Ala-Lys-Asn-Tyr-NH2
-
?
PGC-1alpha + H2O
?
nardilysin and PGC-1alpha interact and colocalize at the uncoupling protein 1 enhancer, where the enzyme represses PGC-1alpha activity
-
-
?
PRAME190-198 + H2O
?
-
nardilysin produces precursors of tumor-associated protein PRAME(190-198) by producing cleavage after Lys200, Arg201 and Lys202 but does not excise precisely at the C terminus (Lys198)
-
-
?
[Ala17,Tyr20]-Somatostatin-28-(10-20)-NH2 + H2O
Pro-Arg-Glu + Arg-Lys-Ala-Gly-Ala-Lys-Asn-Tyr-NH2
2-aminobenzoyl-GGFIR + KVGQ-ethylenediamine-2,4-dinitrophenyl
-
percentage cleaved 0% at IR and 100% at RK
-
-
?
2-aminobenzoyl-GGFIRKVGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGFIR + KVGQ-ethylenediamine-2,4-dinitrophenyl
-
percentage cleaved 100% at RK
-
-
?
2-aminobenzoyl-GGFLR + KVGQ-ethylenediamine-2,4-dinitrophenyl
-
percentage cleaved 23% at FL and 77% at RK
-
-
?
2-aminobenzoyl-GGFLRKVGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGFLR + KVGQ-ethylenediamine-2,4-dinitrophenyl
-
percentage cleaved 23% at KV and 77% at RK
-
-
?
2-aminobenzoyl-GGFLRKVGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGFLR + KVGQ-ethylenediamine-2,4-dinitrophenyl
-
percentage cleaved 23% at LR and 77% at RK
-
-
?
2-aminobenzoyl-GGFY + RKVGQ-ethylenediamine-2,4-dinitrophenyl
-
percentage cleaved 100% at YR
-
-
?
2-aminobenzoyl-GGFYRKVGQ-ethylenediamine-2,4-dinitrophenyl + H2O
2-aminobenzoyl-GGFY + RKVGQ-ethylenediamine-2,4-dinitrophenyl
-
percentage cleaved 100% at YR and 0% at RK
-
-
?
Tyr-Gly-Gly-Phe-Leu-Arg + Lys-Tyr-Pro-Leu
-
i.e. Tyr-Gly-Gly-Phe-Leu-Arg-Lys-Tyr-Pro-Leu, cleavage at Arg-Lys processing site
-
?
alpha-Neoendorphin + H2O
Tyr-Gly-Gly-Phe-Leu-Arg + Lys-Tyr-Pro-Leu
-
i.e. Tyr-Gly-Gly-Phe-Leu-Arg-Lys-Tyr-Pro-Leu, cleavage at Arg-Lys processing site
-
?
Tyr-Gly-Gly-Phe-Met-Arg + Arg-Val-Gly-Arg-Pro-Glu
-
-
-
-
?
Bovine adrenal medulla dodecapeptide + H2O
Tyr-Gly-Gly-Phe-Met-Arg + Arg-Val-Gly-Arg-Pro-Glu
-
i.e. Tyr-Gly-Gly-Phe-Met-Arg-Arg-Val-Gly-Arg-Pro-Glu
-
?
Tyr-Gly-Gly-Phe-Leu-Arg + Arg-Ile-Arg-Pro-Lys-Leu-Lys-Trp-Asp-Asn-Gln-NH2
-
i.e. Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Lys-Leu-Lys-Trp-Asp-Asn-Gln-NH2
-
?
dynorphin A + H2O
Tyr-Gly-Gly-Phe-Leu-Arg + Arg-Ile-Arg-Pro-Lys-Leu-Lys-Trp-Asp-Asn-Gln-NH2
-
i.e. Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Lys-Leu-Lys-Trp-Asp-Asn-Gln-NH2
-
?
Tyr-Gly-Gly-Phe-Leu-Arg + Arg-Ile-Arg-Pro
-
i.e. Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro, cleavage site: Arg-Arg
-
?
dynorphin A-(1-10) + H2O
Tyr-Gly-Gly-Phe-Leu-Arg + Arg-Ile-Arg-Pro
-
i.e. Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro, cleavage site: Arg-Arg
-
?
Tyr-Gly-Gly-Phe-Leu-Arg + Arg-Ile-Arg-Pro-Lys-Leu-Lys
-
i.e. Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Lys-Leu-Lys, cleavage site: Arg-Arg
-
?
dynorphin A-(1-13) + H2O
Tyr-Gly-Gly-Phe-Leu-Arg + Arg-Ile-Arg-Pro-Lys-Leu-Lys
-
i.e. Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Lys-Leu-Lys, cleavage site: Arg-Arg
-
?
Tyr-Gly-Gly-Phe-Leu-Arg + Arg-Ile-Arg
-
i.e. Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg, cleavage site: Arg-Arg
-
?
dynorphin A-(1-9) + H2O
Tyr-Gly-Gly-Phe-Leu-Arg + Arg-Ile-Arg
-
i.e. Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg, cleavage site: Arg-Arg
-
?
Tyr-Gly-Gly-Phe-Leu-Arg + Arg-Gln-Phe-Lys-Val-Val-Thr
-
i.e. Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Gln-Phe-Lys-Val-Val-Thr
-
?
dynorphin B + H2O
Tyr-Gly-Gly-Phe-Leu-Arg + Arg-Gln-Phe-Lys-Val-Val-Thr
-
i.e. Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Gln-Phe-Lys-Val-Val-Thr
-
?
miniglucagon + ?
-
-
miniglucagon, C-terminal glucagon fragment, resulted from cleavage at Arg17-Arg18
-
?
glucagon + H2O
miniglucagon + ?
-
-
miniglucagon, C-terminal glucagon fragment, resulted from cleavage at Arg17-Arg18
-
?
?
-
cleavage site: prohormonal maturation site, Lys-Arg
-
-
?
Somatostatin-28-(13-28) + somatostatin-28-(1-12)
-
-
-
-
?
Somatostatin-28 + H2O
Somatostatin-28-(13-28) + somatostatin-28-(1-12)
-
cleavage on amino side of Arg-Lys doublet
-
-
?
Somatostatin-28 + H2O
Somatostatin-28-(13-28) + somatostatin-28-(1-12)
-
cleavage site: Xaa-+-Arg-Lys, the term -+- depicts the point of cleavage
-
-
?
Somatostatin-28 + H2O
Somatostatin-28-(13-28) + somatostatin-28-(1-12)
-
cleavage site: Glu12-+-Arg13-Lys14, the term -+- depicts the point of cleavage
-
-
?
Somatostatin-28 + H2O
Somatostatin-28-(13-28) + somatostatin-28-(1-12)
-
i.e. octacosapeptide
-
-
?
Pro-Arg-Glu + Arg-Lys-Ala-Gly-Ala-Lys-Asn-Tyr-NH2
-
i.e. model peptide I
-
-
?
[Ala17,Tyr20]-Somatostatin-28-(10-20)-NH2 + H2O
Pro-Arg-Glu + Arg-Lys-Ala-Gly-Ala-Lys-Asn-Tyr-NH2
-
i.e. desiodinated peptide I
-
-
?
[Ala17,Tyr20]-Somatostatin-28-(10-20)-NH2 + H2O
Pro-Arg-Glu + Arg-Lys-Ala-Gly-Ala-Lys-Asn-Tyr-NH2
-
derived from somatostatin-28, mimicking the peptide sequence around the dibasic (i.e. maturation) site
-
-
?
[Ala17,Tyr20]-Somatostatin-28-(10-20)-NH2 + H2O
Pro-Arg-Glu + Arg-Lys-Ala-Gly-Ala-Lys-Asn-Tyr-NH2
-
i.e. Pro-Arg-Glu-Arg-Lys-Ala-Gly-Ala-Lys-Asn-Tyr-NH2
-
-
?
?
-
-
enhancement of alpha-secretase cleavage of amyloid precursor protein by a metalloendopeptidase nardilysin, resulting in down-regulation of beta-amyloid protein, overview, the enzyme also enhances ectodomain shedding of heparin-binding epidermal growth factor-like growth factor through activation of ADAM17, NRDc is regulatorally involved in the metabolism
-
-
?
additional information
?
-
-
expression of nardilysin synergistically enhances TNF-alpha-converting enzyme-induced TNF-alpha ectodomain-shedding via activation of ADAM proteases ADAM9 and ADAM10, activation is independent of protein kinase C, overview
-
-
?
additional information
?
-
-
the enzyme interacts with the brain-specific protein p42IP4/centaurin-alpha1, the interactionis regulated by phosphatidylinositol 3,4,5-triphosphate and inositol-1,3,4,5-tetrakisphophate, nardilysin might play a role in brain development, overview
-
-
?
additional information
?
-
-
the metalloendopeptidase cleaves N-terminal Arg or Lys residues of peptides
-
-
?
additional information
?
-
NRDc interacts with the NCoR/SMRT corepressor complex
-
-
?
additional information
?
-
NRDc is identifiend as a H3K4me2-binding protein. The H3K4me2-binding activity resides in the N-terminal region of NRDc
-
-
?
additional information
?
-
-
tubulin enhances the binding of NRD to functionally p42IP4
-
-
?
additional information
?
-
-
nardilysin can generate both N termini and C termini of CTL epitopes
-
-
?
additional information
?
-
-
physiological substrates of nardilysin have yet to be identified
-
?
additional information
?
-
-
nardilysin enhances ectodomain shedding of neuregulin1, NRG1, a master regulator of myelination in the peripheral nervous system
-
-
?
additional information
?
-
-
[Tyr18]-pro-oxytocin/neurophysin-(1-18)-NH2, Pro-Glu-D-Arg-Lys-Tyr-NH2, Pro-Glu-Arg-D-Lys-Tyr-NH2
-
-
?
additional information
?
-
-
[Tyr20]-somatostatin-28-(13-20)-NH2, dynorphin A-(1-7), [Ala17]-somatostatin-(6-19)-NH2, prosomatostatin-(56-68)-NH2, the Lys-Arg-doublet in preproenkephalin-(128-140) or pro-oxytocin/neurophysin-(1-20)
-
-
?
additional information
?
-
-
[Tyr20]-somatostatin-28-(13-20)-NH2, dynorphin A-(1-7), [Ala17]-somatostatin-(6-19)-NH2, prosomatostatin-(56-68)-NH2, the Lys-Arg-doublet in preproenkephalin-(128-140) or pro-oxytocin/neurophysin-(1-20)
-
-
?
additional information
?
-
-
cleavage occurs selectively at amino-terminal side of an Arg-residue in dibasic stretches
-
-
?
additional information
?
-
-
cleavage occurs selectively at amino-terminal side of an Arg-residue in dibasic stretches
-
-
?
additional information
?
-
-
cleavage occurs selectively at amino-terminal side of an Arg-residue in dibasic stretches
-
-
?
additional information
?
-
-
no aminopeptidase or carboxypeptidase activity
-
-
?
additional information
?
-
-
strict specificity depending upon sequence around Arg-Lys-pair
-
-
?
additional information
?
-
-
cleavage efficiency is higher for the larger substrates
-
-
?
additional information
?
-
-
independent of the nature of the basic doublet of the peptide
-
-
?
additional information
?
-
-
no substrates are dodecapeptide fragment of corticotropin-releasing factor (i.e. Ala-Tyr-Ser-Asn-Arg-Lys-Leu-Leu-Asp-Ile-Ala-NH2)
-
-
?
additional information
?
-
-
utilization of series of fluorogenic peptides containing the sequence 2-aminobenzoyl-GGX1X2RKX3GQ-ethylenediamine-2,4-dinitrophenyl. Residues at positions X1, X2, and X3 are varied to study effects at the P3, P2, and P29 positions, respectively
-
-
?