3.4.24.61: nardilysin
This is an abbreviated version!
For detailed information about nardilysin, go to the full flat file.
Word Map on EC 3.4.24.61
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3.4.24.61
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metalloendopeptidase
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ectodomain
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heparin-binding
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pitrilysins
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adam17
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hb-egf
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insulysin
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insulinase
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hxxeh
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dynorphins
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medicine
- 3.4.24.61
- metalloendopeptidase
- ectodomain
-
heparin-binding
- pitrilysins
- adam17
- hb-egf
- insulysin
- insulinase
-
hxxeh
- dynorphins
- medicine
Reaction
hydrolysis of polypeptides, preferably at -Xaa-/-Arg-Lys-, and less commonly at -Arg-/-Arg-Xaa-, in which Xaa is not Arg or Lys =
Synonyms
hNRDc1, MGE, miniglucagon-generating endopeptidase, More, N-arginine dibasic (NRD) convertase, N-Arginine dibasic convertase, nardilysin, nardilysin (V8), nardilysin convertase, NRD convertase, NRD-convertase, Nrd1, Nrd1 and NRDc, NRDc
ECTree
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Source Tissue
Source Tissue on EC 3.4.24.61 - nardilysin
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in cortical neurons the enzyme is partially co-localized with parvalbumin, but not with calretinin
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NRD is expressed in the neurites of RA-stimulated SHSY5Y cells, and localized in vesicular structures
additional information
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NRDc is expressed almost exclusively in cortical neurons, particularly in large neurons, not in glial cells
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immunolocalisation of nardilysin. In Alzheimer's disease and in Down syndrome brains there is a decreased cellular expression of nardilysin
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reduced neuronal co-localisation of nardilysin and the putative alpha-secretases ADAM10 and ADAM17 in Alzheimers disease and Down syndrome brains
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cerebral cortex, enzyme is catalytically and immunologically related to testis enzyme
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enzyme is catalytically and immunologically related to brain enzyme