3.4.24.61: nardilysin
This is an abbreviated version!
For detailed information about nardilysin, go to the full flat file.
Word Map on EC 3.4.24.61
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3.4.24.61
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metalloendopeptidase
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ectodomain
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heparin-binding
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pitrilysins
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adam17
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hb-egf
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insulysin
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insulinase
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hxxeh
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dynorphins
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medicine
- 3.4.24.61
- metalloendopeptidase
- ectodomain
-
heparin-binding
- pitrilysins
- adam17
- hb-egf
- insulysin
- insulinase
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hxxeh
- dynorphins
- medicine
Reaction
hydrolysis of polypeptides, preferably at -Xaa-/-Arg-Lys-, and less commonly at -Arg-/-Arg-Xaa-, in which Xaa is not Arg or Lys =
Synonyms
hNRDc1, MGE, miniglucagon-generating endopeptidase, More, N-arginine dibasic (NRD) convertase, N-Arginine dibasic convertase, nardilysin, nardilysin (V8), nardilysin convertase, NRD convertase, NRD-convertase, Nrd1, Nrd1 and NRDc, NRDc
ECTree
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Natural Substrates Products on EC 3.4.24.61 - nardilysin
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
amyloid precursor protein + H2O
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the enzyme enhances alpha-cleavage of amyloid precursor protein, which results in the decreased generation of amyloid beta in vitro
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?
heparin-binding epidermal growth factor-like growth factor + H2O
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substrate is synthesized as a transmembrane protein. Enzyme enhances ectodomain shedding of substrate in coperation with tumor necrosis factor-alpha-converting enzyme. Metalloendopeptidase activity of enzyme is not required for enhancement of shedding
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?
PGC-1alpha + H2O
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nardilysin and PGC-1alpha interact and colocalize at the uncoupling protein 1 enhancer, where the enzyme represses PGC-1alpha activity
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?
additional information
?
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enhancement of alpha-secretase cleavage of amyloid precursor protein by a metalloendopeptidase nardilysin, resulting in down-regulation of beta-amyloid protein, overview, the enzyme also enhances ectodomain shedding of heparin-binding epidermal growth factor-like growth factor through activation of ADAM17, NRDc is regulatorally involved in the metabolism
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?
additional information
?
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expression of nardilysin synergistically enhances TNF-alpha-converting enzyme-induced TNF-alpha ectodomain-shedding via activation of ADAM proteases ADAM9 and ADAM10, activation is independent of protein kinase C, overview
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?
additional information
?
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the enzyme interacts with the brain-specific protein p42IP4/centaurin-alpha1, the interactionis regulated by phosphatidylinositol 3,4,5-triphosphate and inositol-1,3,4,5-tetrakisphophate, nardilysin might play a role in brain development, overview
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?
additional information
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NRDc interacts with the NCoR/SMRT corepressor complex
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?
additional information
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NRDc is identifiend as a H3K4me2-binding protein. The H3K4me2-binding activity resides in the N-terminal region of NRDc
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?
additional information
?
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tubulin enhances the binding of NRD to functionally p42IP4
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?
additional information
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physiological substrates of nardilysin have yet to be identified
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?
additional information
?
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nardilysin enhances ectodomain shedding of neuregulin1, NRG1, a master regulator of myelination in the peripheral nervous system
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?
