3.4.24.61: nardilysin

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For detailed information about nardilysin, go to the full flat file.

Word Map on EC 3.4.24.61

3.4.24.61

metalloendopeptidase

ectodomain

heparin-binding

pitrilysins

adam17

hb-egf

insulysin

insulinase

hxxeh

dynorphins

medicine

Reaction

hydrolysis of polypeptides, preferably at -Xaa-/-Arg-Lys-, and less commonly at -Arg-/-Arg-Xaa-, in which Xaa is not Arg or Lys =

Synonyms

hNRDc1, MGE, miniglucagon-generating endopeptidase, More, N-arginine dibasic (NRD) convertase, N-Arginine dibasic convertase, nardilysin, nardilysin (V8), nardilysin convertase, NRD convertase, NRD-convertase, Nrd1, Nrd1 and NRDc, NRDc

ECTree

3 Hydrolases

3.4 Acting on peptide bonds (peptidases)

3.4.24 Metalloendopeptidases

3.4.24.61 nardilysin

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2	Activating Compound
34	AA Sequence
3	Application
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125	Disease/ Diagnostics
4	Expression
20	General Information
50	Inhibitors
92	KM Value [mM]
20	Localization
15	Metals/Ions
17	Molecular Weight [Da]
18	Natural Substrates/ Products (Substrates)
40	Organism
7	pH Optimum
4	pH Range
1	pH Stability
12	Protein Variants
10	Purification (Commentary)
1	Reaction
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172	Substrates and Products (Substrate)
7	Subunits
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5	Temperature Optimum [°C]
1	Temperature Stability [°C]
66	Turnover Number [1/s]

Localization

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Localization on EC 3.4.24.61 - nardilysin

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axoneme

Mus musculus

Q8BHG1

strong and specific accumulation of nardilysin in the manchette and axoneme suggests that the enzyme probably contributes either to the establishment of these specific microtubular structures and/or to their functional properties

p42IP4 (centaurin-alpha), nardilysin and tubulin are found in the cytosol and at the plasma membrane of SH-SY5Y neuroblastoma cells

secretory granule membrane

2 entries

additional information

2 entries