3.4.24.61: nardilysin

This is an abbreviated version!
For detailed information about nardilysin, go to the full flat file.

Reaction

hydrolysis of polypeptides, preferably at -Xaa-/-Arg-Lys-, and less commonly at -Arg-/-Arg-Xaa-, in which Xaa is not Arg or Lys =

Synonyms

hNRDc1, MGE, miniglucagon-generating endopeptidase, More, N-arginine dibasic (NRD) convertase, N-Arginine dibasic convertase, nardilysin, nardilysin (V8), nardilysin convertase, NRD convertase, NRD-convertase, Nrd1, Nrd1 and NRDc, NRDc

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.24 Metalloendopeptidases

                3.4.24.61 nardilysin

Advanced search results

Do not include text mining results

Include results (more...)

Include results (more...)

Results	in table
2	Activating Compound
34	AA Sequence
3	Application
2	CAS Registry Number
9	Cloned(Commentary)
125	Disease/ Diagnostics
4	Expression
20	General Information
50	Inhibitors
92	KM Value [mM]
20	Localization
15	Metals/Ions
17	Molecular Weight [Da]
18	Natural Substrates/ Products (Substrates)
40	Organism
7	pH Optimum
4	pH Range
1	pH Stability
12	Protein Variants
10	Purification (Commentary)
1	Reaction
1	Reaction Type
40	Reference
50	Source Tissue
172	Substrates and Products (Substrate)
7	Subunits
55	Synonyms
5	Temperature Optimum [°C]
1	Temperature Stability [°C]
66	Turnover Number [1/s]

KM Value

print visible entries

print all entries

Go back to the abbreviated version
of the Enzyme Summary Page.

KM Value on EC 3.4.24.61 - nardilysin

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

top print hide show all columns Go to KM Value Search

Please wait a moment until the data is sorted. This message will disappear when the data is sorted.

KM VALUE [mM]

SUBSTRATE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

0.0019

2-aminobenzoyl-GFSPFRSSRQED(2,4-dinitrophenyl)

Mus musculus

-

pH 7.0, 37°C

650203

0.0074

2-aminobenzoyl-GGALRKVGQ-ethylenediamine-2,4-dinitrophenyl

Rattus norvegicus

-

pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGXLRKVGQ-ethylenediamine-2,4-dinitrophenyl

652006

0.0061

2-aminobenzoyl-GGFARKVGQ-ethylenediamine-2,4-dinitrophenyl

Rattus norvegicus

-

pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGFXRKVGQ-ethylenediamine-2,4-dinitrophenyl

652006

0.0094

2-aminobenzoyl-GGFFRKVGQ-ethylenediamine-2,4-dinitrophenyl

Rattus norvegicus

-

pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGFXRKVGQ-ethylenediamine-2,4-dinitrophenyl

652006

0.0044

2-aminobenzoyl-GGFHRKVGQ-ethylenediamine-2,4-dinitrophenyl

Rattus norvegicus

-

pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGFXRKVGQ-ethylenediamine-2,4-dinitrophenyl

652006

0.0075

2-aminobenzoyl-GGFIKKVGQ-ethylenediamine-2,4-dinitrophenyl

Rattus norvegicus

-

pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGFIXXVGQ-ethylenediamine-2,4-dinitrophenyl

652006

0.0074

2-aminobenzoyl-GGFIKRVGQ-ethylenediamine-2,4-dinitrophenyl

Rattus norvegicus

-

pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGFIXXVGQ-ethylenediamine-2,4-dinitrophenyl

652006

0.0062 - 0.0072

2-aminobenzoyl-GGFIRKVGQ-ethylenediamine-2,4-dinitrophenyl

2 entries

0.0033

2-aminobenzoyl-GGFIRRVGQ-ethylenediamine-2,4-dinitrophenyl

Rattus norvegicus

-

pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGFIXXVGQ-ethylenediamine-2,4-dinitrophenyl

652006

0.0014

2-aminobenzoyl-GGFIRRVGQ-N-(2,4-dinitrophenyl)ethylenediamine

Mus musculus

-

pH 7.0, 37°C

650203

0.0073

2-aminobenzoyl-GGFLKKVGQ-ethylenediamine-2,4-dinitrophenyl

Rattus norvegicus

-

pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGFLXXVGQ-ethylenediamine-2,4-dinitrophenyl

652006

0.0051

2-aminobenzoyl-GGFLKRVGQ-ethylenediamine-2,4-dinitrophenyl

Rattus norvegicus

-

pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGFLXXVGQ-ethylenediamine-2,4-dinitrophenyl

652006

0.01

2-aminobenzoyl-GGFLRKAGQ-ethylenediamine-2,4-dinitrophenyl

Rattus norvegicus

-

pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGFLRKXGQ-ethylenediamine-2,4-dinitrophenyl

652006

0.011

2-aminobenzoyl-GGFLRKDGQ-ethylenediamine-2,4-dinitrophenyl

Rattus norvegicus

-

pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGFLRKXGQ-ethylenediamine-2,4-dinitrophenyl

652006

0.0066

2-aminobenzoyl-GGFLRKFGQ-ethylenediamine-2,4-dinitrophenyl

Rattus norvegicus

-

pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGFLRKXGQ-ethylenediamine-2,4-dinitrophenyl

652006

0.0048

2-aminobenzoyl-GGFLRKHGQ-ethylenediamine-2,4-dinitrophenyl

Rattus norvegicus

-

pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGFLRKXGQ-ethylenediamine-2,4-dinitrophenyl

652006

0.0051

2-aminobenzoyl-GGFLRKIGQ-ethylenediamine-2,4-dinitrophenyl

Rattus norvegicus

-

pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGFLRKXGQ-ethylenediamine-2,4-dinitrophenyl

652006

0.0049

2-aminobenzoyl-GGFLRKLGQ-ethylenediamine-2,4-dinitrophenyl

Rattus norvegicus

-

pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGFLRKXGQ-ethylenediamine-2,4-dinitrophenyl

652006

0.0075

2-aminobenzoyl-GGFLRKMGQ-ethylenediamine-2,4-dinitrophenyl

Rattus norvegicus

-

pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGFLRKXGQ-ethylenediamine-2,4-dinitrophenyl

652006

0.0097

2-aminobenzoyl-GGFLRKNGQ-ethylenediamine-2,4-dinitrophenyl

Rattus norvegicus

-

pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGFLRKXGQ-ethylenediamine-2,4-dinitrophenyl

652006

0.0101

2-aminobenzoyl-GGFLRKSGQ-ethylenediamine-2,4-dinitrophenyl

Rattus norvegicus

-

pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGFLRKXGQ-ethylenediamine-2,4-dinitrophenyl

652006

0.0057 - 0.0065

2-aminobenzoyl-GGFLRKVGQ-ethylenediamine-2,4-dinitrophenyl

2 entries

0.0055

2-aminobenzoyl-GGFLRKWGQ-ethylenediamine-2,4-dinitrophenyl

Rattus norvegicus

-

pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGFLRKXGQ-ethylenediamine-2,4-dinitrophenyl

652006

0.0036

2-aminobenzoyl-GGFLRRVGQ-ethylenediamine-2,4-dinitrophenyl

Rattus norvegicus

-

pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGFLXXVGQ-ethylenediamine-2,4-dinitrophenyl

652006

0.00023 - 0.03

2-aminobenzoyl-GGFLRRVGQ-N[2,4-dinitrophenyl]-ethylenediamine

7 entries

0.0072

2-aminobenzoyl-GGFMRKVGQ-ethylenediamine-2,4-dinitrophenyl

Rattus norvegicus

-

pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGFXRKVGQ-ethylenediamine-2,4-dinitrophenyl

652006

0.003

2-aminobenzoyl-GGFNRKVGQ-ethylenediamine-2,4-dinitrophenyl

Rattus norvegicus

-

pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGFXRKVGQ-ethylenediamine-2,4-dinitrophenyl

652006

0.004

2-aminobenzoyl-GGFSRKVGQ-ethylenediamine-2,4-dinitrophenyl

Rattus norvegicus

-

pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGFXRKVGQ-ethylenediamine-2,4-dinitrophenyl

652006

0.0095

2-aminobenzoyl-GGFVRKVGQ-ethylenediamine-2,4-dinitrophenyl

Rattus norvegicus

-

pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGFXRKVGQ-ethylenediamine-2,4-dinitrophenyl

652006

0.0053

2-aminobenzoyl-GGFWRKVGQ-ethylenediamine-2,4-dinitrophenyl

Rattus norvegicus

-

pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGFXRKVGQ-ethylenediamine-2,4-dinitrophenyl

652006

0.0039

2-aminobenzoyl-GGFYKKVGQ-ethylenediamine-2,4-dinitrophenyl

Rattus norvegicus

-

pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGFYXXVGQ-ethylenediamine-2,4-dinitrophenyl

652006

0.003

2-aminobenzoyl-GGFYKRVGQ-ethylenediamine-2,4-dinitrophenyl

Rattus norvegicus

-

pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGFYXXVGQ-ethylenediamine-2,4-dinitrophenyl

652006

0.0083 - 0.0094

2-aminobenzoyl-GGFYRKVGQ-ethylenediamine-2,4-dinitrophenyl

2 entries

0.0026

2-aminobenzoyl-GGFYRRVGQ-ethylenediamine-2,4-dinitrophenyl

Rattus norvegicus

-

pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGFYXXVGQ-ethylenediamine-2,4-dinitrophenyl

652006

0.0057

2-aminobenzoyl-GGHLRKVGQ-ethylenediamine-2,4-dinitrophenyl

Rattus norvegicus

-

pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGXLRKVGQ-ethylenediamine-2,4-dinitrophenyl

652006

0.0064

2-aminobenzoyl-GGILRKVGQ-ethylenediamine-2,4-dinitrophenyl

Rattus norvegicus

-

pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGXLRKVGQ-ethylenediamine-2,4-dinitrophenyl

652006

0.0091

2-aminobenzoyl-GGLLRKVGQ-ethylenediamine-2,4-dinitrophenyl

Rattus norvegicus

-

pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGXLRKVGQ-ethylenediamine-2,4-dinitrophenyl

652006

0.0067

2-aminobenzoyl-GGMLRKVGQ-ethylenediamine-2,4-dinitrophenyl

Rattus norvegicus

-

pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGXLRKVGQ-ethylenediamine-2,4-dinitrophenyl

652006

0.0054

2-aminobenzoyl-GGNLRKVGQ-ethylenediamine-2,4-dinitrophenyl

Rattus norvegicus

-

pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGXLRKVGQ-ethylenediamine-2,4-dinitrophenyl

652006

0.0065

2-aminobenzoyl-GGSLRKVGQ-ethylenediamine-2,4-dinitrophenyl

Rattus norvegicus

-

pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGXLRKVGQ-ethylenediamine-2,4-dinitrophenyl

652006

0.0092

2-aminobenzoyl-GGVLRKVGQ-ethylenediamine-2,4-dinitrophenyl

Rattus norvegicus

-

pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGXLRKVGQ-ethylenediamine-2,4-dinitrophenyl

652006

0.008

2-aminobenzoyl-GGWLRKVGQ-ethylenediamine-2,4-dinitrophenyl

Rattus norvegicus

-

pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGXLRKVGQ-ethylenediamine-2,4-dinitrophenyl

652006

0.0092

2-aminobenzoyl-GGYLRKVGQ-ethylenediamine-2,4-dinitrophenyl

Rattus norvegicus

-

pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGXLRKVGQ-ethylenediamine-2,4-dinitrophenyl

652006

0.0041

2-aminobenzoyl-MISLMKRPPGFSPFRSSRINH2

Mus musculus

-

pH 7.0, 37°C

650203

0.0035

2-aminobenzoyl-MISLMKRPQED(2,4-dinitrophenyl)

Mus musculus

-

pH 7.0, 37°C

650203

0.00054 - 0.0466

2-aminobenzoyl-TPLVTLX1X2NAIIKQED(2,4-dinitrophenyl)

8 entries

0.974

alpha-neoendorphin

Rattus norvegicus

-

-

31365, 31369

0.00625

ANF-(1-28)

Rattus norvegicus

-

-

31365, 31369

0.0014

betaendorphin

Mus musculus

-

pH 7.0, 37°C

650203

0.103

Bovine adrenal medulla dodecapeptide

Rattus norvegicus

-

-

31365, 31369

0.0017

calcitonin

Mus musculus

-

pH 7.0, 37°C

650203

0.00645

dynorphin A

Rattus norvegicus

-

-

31365, 31369

0.127

dynorphin A-(1-10)

Rattus norvegicus

-

-

31365, 31369

0.024

dynorphin A-(1-13)

Rattus norvegicus

-

-

31365, 31369

0.162

dynorphin A-(1-9)

Rattus norvegicus

-

-

31365, 31369

0.209

dynorphin B

Rattus norvegicus

-

-

31365, 31369

0.002

dynorphin B13

Mus musculus

-

pH 7.0, 37°C

650203

0.0173

Preproneurotensin-(154-170)

Rattus norvegicus

-

-

31365, 31369

0.0005 - 0.008

Somatostatin-14

2 entries

0.0055 - 0.043

Somatostatin-28

2 entries

0.428

[Ala17,Tyr20]-Somatostatin-28-(10-20)-NH2

2 entries

0.227

[Arg0,Ala17]-somatostatin-28-(1-19)-NH2

Rattus norvegicus

-

-

31365, 31369

0.0062

2-aminobenzoyl-GGFIRKVGQ-ethylenediamine-2,4-dinitrophenyl

Rattus norvegicus

-

pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGFXRKVGQ-ethylenediamine-2,4-dinitrophenyl

652006

0.0072

2-aminobenzoyl-GGFIRKVGQ-ethylenediamine-2,4-dinitrophenyl

Rattus norvegicus

-

pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGFIXXVGQ-ethylenediamine-2,4-dinitrophenyl

652006

0.0057

2-aminobenzoyl-GGFLRKVGQ-ethylenediamine-2,4-dinitrophenyl

Rattus norvegicus

-

pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGFLRKXGQ-ethylenediamine-2,4-dinitrophenyl

652006

0.0065

2-aminobenzoyl-GGFLRKVGQ-ethylenediamine-2,4-dinitrophenyl

Rattus norvegicus

-

pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGFXRKVGQ-ethylenediamine-2,4-dinitrophenyl and hydrolysis of the peptide series 2-aminobenzoyl-GGXLRKVGQ-ethylenediamine-2,4-dinitrophenyl and hydrolysis of the peptide series 2-aminobenzoyl-GGFLXXVGQ-ethylenediamine-2,4-dinitrophenyl

652006

0.00023

2-aminobenzoyl-GGFLRRVGQ-N[2,4-dinitrophenyl]-ethylenediamine

Rattus norvegicus

-

pH 6.5, 34°C

649420

0.00031

2-aminobenzoyl-GGFLRRVGQ-N[2,4-dinitrophenyl]-ethylenediamine

Rattus norvegicus

-

pH 8.0, 34°C

649420

0.0015

2-aminobenzoyl-GGFLRRVGQ-N[2,4-dinitrophenyl]-ethylenediamine

Rattus norvegicus

-

pH 6.0, 34°C

649420

0.00192

2-aminobenzoyl-GGFLRRVGQ-N[2,4-dinitrophenyl]-ethylenediamine

Rattus norvegicus

-

pH 8.0, 34°C, 25 mM KCl

649420

0.002

2-aminobenzoyl-GGFLRRVGQ-N[2,4-dinitrophenyl]-ethylenediamine

Rattus norvegicus

-

pH 6.5, 34°C, 50 mM KCl

649420

0.0158

2-aminobenzoyl-GGFLRRVGQ-N[2,4-dinitrophenyl]-ethylenediamine

Rattus norvegicus

-

pH 6.5, 34°C, 500 mM KCl

649420

0.03

2-aminobenzoyl-GGFLRRVGQ-N[2,4-dinitrophenyl]-ethylenediamine

Rattus norvegicus

-

pH 8.2, 34°C

649420

0.0083

2-aminobenzoyl-GGFYRKVGQ-ethylenediamine-2,4-dinitrophenyl

Rattus norvegicus

-

pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGFYXXVGQ-ethylenediamine-2,4-dinitrophenyl

652006

0.0094

2-aminobenzoyl-GGFYRKVGQ-ethylenediamine-2,4-dinitrophenyl

Rattus norvegicus

-

pH 7.0, hydrolysis of the peptide series 2-aminobenzoyl-GGFXRKVGQ-ethylenediamine-2,4-dinitrophenyl and hydrolysis of the peptide series 2-aminobenzoyl-GGFLXXVGQ-ethylenediamine-2,4-dinitrophenyl

652006

0.00054

2-aminobenzoyl-TPLVTLX1X2NAIIKQED(2,4-dinitrophenyl)

Mus musculus

-

pH 7.0, 37°C, R-K

650203

0.00117

2-aminobenzoyl-TPLVTLX1X2NAIIKQED(2,4-dinitrophenyl)

Mus musculus

-

pH 7.0, 37°C, KK

650203

0.0077

2-aminobenzoyl-TPLVTLX1X2NAIIKQED(2,4-dinitrophenyl)

Mus musculus

-

pH 7.0, 37°C, F-K

650203

0.0084

2-aminobenzoyl-TPLVTLX1X2NAIIKQED(2,4-dinitrophenyl)

Mus musculus

-

pH 7.0, 37°C, WK

650203

0.0135

2-aminobenzoyl-TPLVTLX1X2NAIIKQED(2,4-dinitrophenyl)

Mus musculus

-

pH 7.0, 37°C, MK

650203

0.0171

2-aminobenzoyl-TPLVTLX1X2NAIIKQED(2,4-dinitrophenyl)

Mus musculus

-

pH 7.0, 37°C, FR

650203

0.0266

2-aminobenzoyl-TPLVTLX1X2NAIIKQED(2,4-dinitrophenyl)

Mus musculus

-

pH 7.0, 37°C, YK

650203

0.0466

2-aminobenzoyl-TPLVTLX1X2NAIIKQED(2,4-dinitrophenyl)

Mus musculus

-

pH 7.0, 37°C, L-K

650203

0.0005

Somatostatin-14

Mus musculus

-

pH 7.0, 37°C

650203

0.008

Somatostatin-14

Mus musculus

-

pH 7.0, 37°C

650203

0.0055

Somatostatin-28

Rattus norvegicus

-

-

31366

0.043

Somatostatin-28

Rattus norvegicus

-

-

31365, 31369

0.428

[Ala17,Tyr20]-Somatostatin-28-(10-20)-NH2

Rattus norvegicus

-

-

31365

0.428

[Ala17,Tyr20]-Somatostatin-28-(10-20)-NH2

Rattus norvegicus

-

or peptide I

31369