3.4.24.61: nardilysin

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For detailed information about nardilysin, go to the full flat file.

Reaction

hydrolysis of polypeptides, preferably at -Xaa-/-Arg-Lys-, and less commonly at -Arg-/-Arg-Xaa-, in which Xaa is not Arg or Lys =

Synonyms

hNRDc1, MGE, miniglucagon-generating endopeptidase, More, N-arginine dibasic (NRD) convertase, N-Arginine dibasic convertase, nardilysin, nardilysin (V8), nardilysin convertase, NRD convertase, NRD-convertase, Nrd1, Nrd1 and NRDc, NRDc

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.24 Metalloendopeptidases

                3.4.24.61 nardilysin

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92	KM Value [mM]
20	Localization
15	Metals/Ions
17	Molecular Weight [Da]
18	Natural Substrates/ Products (Substrates)
40	Organism
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172	Substrates and Products (Substrate)
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Activating Compound

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Activating Compound on EC 3.4.24.61 - nardilysin

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ACTIVATING COMPOUND

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

p42IP4

Homo sapiens

-

p42IP4 (centaurin alpha1) enhances the enzymatic activity of NRD 3-4 times.

720552

-

additional information

Rattus norvegicus

-

increase in enzyme activity by 50% upon formation of complex with mitochondrial malate dehydrogenase

667791

-