3.4.24.59: mitochondrial intermediate peptidase

This is an abbreviated version, for detailed information about mitochondrial intermediate peptidase, go to the full flat file.

Reaction

release of an N-terminal octapeptide as second stage of processing of some proteins imported into the mitochondrion =

Synonyms

hMIP, Icp55, MIP, MIP1, MIPEP, mitochondrial intermediate peptidase, OCT1, octapeptidyl aminopeptidase 1, Proteinase, mitochondrial intermediate precursor-processing

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.24 Metalloendopeptidases
                3.4.24.59 mitochondrial intermediate peptidase

Substrates Products

Substrates Products on EC 3.4.24.59 - mitochondrial intermediate peptidase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
51 kDa subunit of complex I + H2O
?
show the reaction diagram
W6HYK5
substrate of isoform ICP55
-
-
?
ABC transporter of the mitochondrion 1 + H2O
?
show the reaction diagram
W6HYK5
substrate of isoform ICP55
-
-
?
Abz-FQTKVAAK(Dnp)-NH2 + H2O
Abz-FQ + TKVAAK(Dnp)-NH2
show the reaction diagram
-
-
-
-
?
Abz-FRSGQPLQNKVQLQ-ED(Dnp) + H2O
Abz-FRSGQPLQ + NKVQLQ-ED(Dnp)
show the reaction diagram
-
-
-
-
?
Abz-FSSKTTVK(Dnp)-NH2 + H2O
Abz-FS + SKTTVK(Dnp)-NH2
show the reaction diagram
-
-
-
-
?
Abz-GFSPFRQ-EDDnp + H2O
Abz-GF + SPFRQ-EDDnp
show the reaction diagram
-
-
-
-
?
Abz-IKQSSLLK(Dnp)-NH2 + H2O
Abz-IKQ + SSLLK(Dnp)-NH2
show the reaction diagram
-
-
-
-
?
Abz-MTAALKTK(Dnp)-NH2 + H2O
Abz-MT + AALK + TK(Dnp)-NH2
show the reaction diagram
-
-
-
-
?
Abz-NLMKKSTK(Dnp)-NH2 + H2O
Abz-NLM + KKSTK(Dnp)-NH2
show the reaction diagram
-
-
-
-
?
Abz-QPLANKVQ-ED(Dnp) + H2O
Abz-QPLA + NKVQ-ED(Dnp)
show the reaction diagram
-
-
-
-
?
Abz-QPLQAKVQ-ED(Dnp) + H2O
Abz-QPLQ + AKVQ-ED(Dnp)
show the reaction diagram
-
-
-
-
?
Abz-QPLQNKVQ-ED(Dnp) + H2O
Abz-QPLQ + NKVQ-ED(Dnp)
show the reaction diagram
-
-
-
-
?
Abz-RPPGFSPFRQ-EDDnp + H2O
Abz-RPPGF + SPFRQ-EDDnp
show the reaction diagram
-
-
-
-
?
Abz-TTKLKAAK(Dnp)-NH2 + H2O
Abz-TTKL + L-Lys + L-Ala + AK(Dnp)-NH2
show the reaction diagram
-
-
-
-
?
Abz-VAAQTKTK(Dnp)-NH2 + H2O
Abz-VAA + QTKTK(Dnp)-NH2
show the reaction diagram
-
-
-
-
?
Abz-VISSRLEK(Dnp)-NH2 + H2O
Abz-VIS + SRLEK(Dnp)-NH2
show the reaction diagram
-
-
-
-
?
Abz-VRNFRSGQPLQNKVQED(Dnp) + H2O
Abz-VRNFRSGQPLQ + NKVQED(Dnp)
show the reaction diagram
-
-
-
-
?
Abz-WTTGGKAK(Dnp)-NH2 + H2O
Abz-WT + TGGKAK(Dnp)-NH2
show the reaction diagram
-
-
-
-
?
alanine aminotransferase + H2O
?
show the reaction diagram
W6HYK5
substrate of isoform ICP55
-
-
?
alanine aminotransferase 2 + H2O
?
show the reaction diagram
W6HYK5
substrate of isoform ICP55
-
-
?
alanine:glyoxylate aminotransferase 3 + H2O
?
show the reaction diagram
W6HYK5
substrate of isoform ICP55
-
-
?
aldehyde dehydrogenase 2B + H2O
?
show the reaction diagram
W6HYK5
substrate of isoform ICP55
-
-
?
aldehyde dehydrogenase 6B + H2O
?
show the reaction diagram
W6HYK5
substrate of isoform ICP55
-
-
?
alpha/beta-hydrolases superfamily protein + H2O
?
show the reaction diagram
W6HYK5
substrate of isoform ICP55
-
-
?
alternative oxidase 1D + H2O
?
show the reaction diagram
W6HYK5
substrate of isoform ICP55
-
-
?
arginase + H2O
?
show the reaction diagram
W6HYK5
substrate of isoform ICP55
-
-
?
ascorbate peroxidase + H2O
?
show the reaction diagram
W6HYK5
substrate of isoform ICP55
-
-
?
ATP synthase beta + H2O
?
show the reaction diagram
W6HYK5
substrate of isoform ICP55
-
-
?
ATP-dependent caseinolytic protease + H2O
?
show the reaction diagram
W6HYK5
substrate of isoform ICP55
-
-
?
B13 NADH complex protein + H2O
?
show the reaction diagram
W6HYK5
substrate of isoform OCT1
-
-
?
Bradykinin + H2O
?
show the reaction diagram
-
-
-
-
?
coenzyme Q 3 + H2O
?
show the reaction diagram
W6HYK5
substrate of isoform ICP55
-
-
?
cofactor of nitrate reductase + H2O
?
show the reaction diagram
W6HYK5
substrate of isoform ICP55
-
-
?
copper ion binding protein + H2O
?
show the reaction diagram
W6HYK5
substrate of isoform ICP55
-
-
?
cytochrome c oxidase 4 precursor protein + H2O
mature cytochrome c oxidase + propeptide
show the reaction diagram
dihydrolipoamide acetyltransferase + H2O
?
show the reaction diagram
W6HYK5
substrate of isoform ICP55
-
-
?
dihydrolipoamide succinyltransferase + H2O
?
show the reaction diagram
W6HYK5
substrate of isoform ICP55
-
-
?
electron transfer flavoprotein alpha + H2O
?
show the reaction diagram
W6HYK5
substrate of isoform ICP55
-
-
?
FAD-linked oxidases family protein + H2O
?
show the reaction diagram
W6HYK5
substrate of isoform ICP55
-
-
?
frataxin + H2O
?
show the reaction diagram
-
-
-
-
?
FTSH protease 4 + H2O
?
show the reaction diagram
W6HYK5
substrate of isoform ICP55
-
-
?
fumarase 1 + H2O
?
show the reaction diagram
W6HYK5
substrate of isoform ICP55
-
-
?
glutamate tRNA synthetase + H2O
?
show the reaction diagram
W6HYK5
substrate of isoform ICP55
-
-
?
glutathione reductase + H2O
?
show the reaction diagram
W6HYK5
substrate of isoform ICP55
-
-
?
HSP60 + H2O
?
show the reaction diagram
W6HYK5
substrate of isoform ICP55
-
-
?
Hsp60-3 + H2O
?
show the reaction diagram
W6HYK5
substrate of isoform ICP55
-
-
?
Hsp70-1 + H2O
?
show the reaction diagram
W6HYK5
substrate of isoform ICP55
-
-
?
Hsp70-2 + H2O
?
show the reaction diagram
W6HYK5
substrate of isoform ICP55
-
-
?
iron-sulfur cluster biosynthesis family protein + H2O
?
show the reaction diagram
W6HYK5
substrate of isoform ICP55
-
-
?
isopentenyl diphosphate isomerase + H2O
?
show the reaction diagram
W6HYK5
substrate of isoform ICP55
-
-
?
lactate/malate dehydrogenase family protein + H2O
?
show the reaction diagram
W6HYK5
substrate of isoform ICP55
-
-
?
lipoamide dehydrogenase 2 + H2O
?
show the reaction diagram
W6HYK5
substrate of isoform ICP55
-
-
?
methylenetetrahydrofolate reductase family protein + H2O
?
show the reaction diagram
W6HYK5
substrate of isoform ICP55
-
-
?
mitochondrial acyl carrier protein 1 + H2O
?
show the reaction diagram
W6HYK5
substrate of isoform ICP55
-
-
?
mitochondrial acyl carrier protein 2 + H2O
?
show the reaction diagram
W6HYK5
substrate of isoform ICP55
-
-
?
mitochondrial acyl carrier protein 3 + H2O
?
show the reaction diagram
W6HYK5
substrate of isoform ICP55
-
-
?
mitochondrial glycoprotein family protein + H2O
?
show the reaction diagram
W6HYK5
substrate of isoform ICP55
-
-
?
Mitochondrial intermediate proteins + H2O
?
show the reaction diagram
mitochondrial RNA helicase 2 + H2O
?
show the reaction diagram
W6HYK5
substrate of isoform OCT1
-
-
?
monodehydroascorbate reductase 6 + H2O
?
show the reaction diagram
W6HYK5
substrate of isoform ICP55
-
-
?
MPP beta + H2O
?
show the reaction diagram
W6HYK5
substrate of isoform ICP55
-
-
?
NAD(P)-binding Rossmann-fold superfamily protein + H2O
?
show the reaction diagram
W6HYK5
substrate of isoform ICP55
-
-
?
NADH-ubiquinone oxidoreductase-related protein + H2O
?
show the reaction diagram
W6HYK5
substrate of isoform ICP55
-
-
?
NADPH-dependent thioredoxin reductase B + H2O
?
show the reaction diagram
W6HYK5
substrate of isoform ICP55
-
-
?
Notch receptor + H2O
?
show the reaction diagram
-
Notch is proteolysed at the S5 site which is 8 amino acids downstream of the S3 site, generating a DELTA NICD (Notch intracellular domain) fragment
-
-
?
nuclear-encoded CLP protease P7 + H2O
?
show the reaction diagram
W6HYK5
substrate of isoform ICP55
-
-
?
O-acetylserine (thiol) lyase isoform C + H2O
?
show the reaction diagram
W6HYK5
substrate of isoform ICP55
-
-
?
octapeptide from the mitochondrial processing peptidase-generated N-terminus in the substrate proteins + H2O
?
show the reaction diagram
-
-
-
-
?
Oxa1 + H2O
?
show the reaction diagram
W6HYK5
substrate of isoform ICP55
-
-
?
pentatricopeptide repeat protein + H2O
?
show the reaction diagram
W6HYK5
substrate of isoform ICP55
-
-
?
peroxiredoxin IIF + H2O
?
show the reaction diagram
W6HYK5
substrate of isoform ICP55
-
-
?
phenylalanyl-tRNA synthetase + H2O
?
show the reaction diagram
W6HYK5
substrate of isoform ICP55
-
-
?
polyketide + H2O
?
show the reaction diagram
W6HYK5
substrate of isoform ICP55
-
-
?
Precursor proteins that have already been processed by mitochondrial processing peptidase + H2O
?
show the reaction diagram
primosome PriB/single-strand DNA-binding protein + H2O
?
show the reaction diagram
W6HYK5
substrate of isoform ICP55
-
-
?
proteinaceous RNase P1 + H2O
?
show the reaction diagram
W6HYK5
substrate of isoform OCT1
-
-
?
Proteins with the octapeptide Phe-Xaa-Xaa-Ser-Xaa-Xaa-Xaa-Xaa at the amino termini + H2O
Protein + Phe-Xaa-Xaa-Ser-Xaa-Xaa-Xaa-Xaa
show the reaction diagram
-
amino-terminal octapeptide can be cleaved only within the structural context of twice-cleaved precursors
-
-
-
radical SAM superfamily protein + H2O
?
show the reaction diagram
W6HYK5
substrate of isoform ICP55
-
-
?
ribosomal protein L3 + H2O
?
show the reaction diagram
W6HYK5
substrate of isoform ICP55
-
-
?
Rieske iron sulfur protein from complex III + H2O
?
show the reaction diagram
W6HYK5
substrate of isoform OCT1
-
-
?
rubredoxin-like superfamily protein + H2O
?
show the reaction diagram
W6HYK5
substrate of isoform ICP55
-
-
?
S-adenosyl-L-methionine-dependent methyltransferase + H2O
?
show the reaction diagram
W6HYK5
substrate of isoform ICP55
-
-
?
succinate dehydrogenase 1-1 + H2O
?
show the reaction diagram
W6HYK5
substrate of isoform ICP55
-
-
?
succinyl-CoA ligase + H2O
?
show the reaction diagram
W6HYK5
substrate of isoform ICP55
-
-
?
succinyl-CoA ligase alpha subunit + H2O
?
show the reaction diagram
W6HYK5
substrate of isoform ICP55
-
-
?
transketolase family protein + H2O
?
show the reaction diagram
W6HYK5
substrate of isoform ICP55
-
-
?
translation elongation factor Ts + H2O
?
show the reaction diagram
W6HYK5
substrate of isoform ICP55
-
-
?
UDP-3-O-acyl N-acetylglycosamine deacetylase + H2O
?
show the reaction diagram
W6HYK5
substrate of isoform ICP55
-
-
?
valyl-tRNA synthetase + H2O
?
show the reaction diagram
W6HYK5
substrate of isoform OCT1
-
-
?
Ygr031w/Imo32 + H2O
?
show the reaction diagram
-
Ygr031w/Imo32 encodes an Oct1 substrate protein with an unusual sequence motif
-
-
?
additional information
?
-