3.4.24.59: mitochondrial intermediate peptidase

This is an abbreviated version, for detailed information about mitochondrial intermediate peptidase, go to the full flat file.

Reaction

release of an N-terminal octapeptide as second stage of processing of some proteins imported into the mitochondrion =

Synonyms

hMIP, Icp55, MIP, MIP1, MIPEP, mitochondrial intermediate peptidase, OCT1, octapeptidyl aminopeptidase 1, Proteinase, mitochondrial intermediate precursor-processing

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.24 Metalloendopeptidases
                3.4.24.59 mitochondrial intermediate peptidase

Reference

Reference on EC 3.4.24.59 - mitochondrial intermediate peptidase

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Isaya, G.; Kalousek, F.; Rosenberg, L.E.
Amino-terminal octapeptides function as recognition signals for the mitochondrial intermediate peptidase
J. Biol. Chem.
267
7904-7910
1992
Rattus norvegicus
Manually annotated by BRENDA team
Isaya, G.; Kalousek, F.; Rosenberg, L.E.
Sequence analysis of rat mitochondrial intermediate peptidase: similarity to zinc metallopeptidases and to a putative yeast homologue
Proc. Natl. Acad. Sci. USA
89
8317-8321
1992
Rattus norvegicus
Manually annotated by BRENDA team
Isaya, G.; Miklos, D.; Rollins, R.A.
MIP1, a new yeast gene homologous to the rat mitochondrial intermediate peptidase gene, is required for oxidative metabolism in Saccharomyces cerevisiae
Mol. Cell. Biol.
14
5603-5616
1994
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Isaya, G.; Kalousek, F.
Mitochondrial intermediate peptidase
Methods Enzymol.
248
556-567
1995
Rattus norvegicus
Manually annotated by BRENDA team
Kalousek, F.; Isaya, G.; Rosenberg, L.E.
Rat liver mitochondrial intermediate peptidase (MIP): purification and initial characterization
EMBO J.
11
2803-2809
1992
Rattus norvegicus
Manually annotated by BRENDA team
Branda, S.S.; Isaya, G.
Prediction and identification of new natural substrates of the yeast mitochondrial intermediate peptidase
J. Biol. Chem.
270
27366-27373
1995
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Isaya, G.
Mitochondrial intermediate peptidase
Handbook Of Proteolytic Enzymes(Barrett,A. J. ,Rawlings,N. D. ,Woessner,J. F. ,Eds. )Academic Press
1
366-369
2004
Homo sapiens, Mus musculus, Rattus norvegicus, Saccharomyces cerevisiae, Schizophyllum commune
-
Manually annotated by BRENDA team
Hervouet, E.; Pecina, P.; Demont, J.; Vojtiskova, A.; Simonnet, H.; Houstek, J.; Godinot, C.
Inhibition of cytochrome c oxidase subunit 4 precursor processing by the hypoxia mimic cobalt chloride
Biochem. Biophys. Res. Commun.
344
1086-1093
2006
Homo sapiens
Manually annotated by BRENDA team
van der Nest, M.A.; Slippers, B.; Stenlid, J.; Wilken, P.M.; Vasaitis, R.; Wingfield, M.J.; Wingfield, B.D.
Characterization of the systems governing sexual and self-recognition in the white rot homobasidiomycete Amylostereum areolatum
Curr. Genet.
53
323-336
2008
Amylostereum areolatum
Manually annotated by BRENDA team
Marcondes, M.; Torquato, R.; Assis, D.; Juliano, M.; Hayashi, M.; Oliveira, V.
Mitochondrial intermediate peptidase: Expression in Escherichia coli and improvement of its enzymatic activity detection with FRET substrates
Biochem. Biophys. Res. Commun.
391
123-128
2010
Homo sapiens
Manually annotated by BRENDA team
Lee, S.F.; Srinivasan, B.; Sephton, C.F.; Dries, D.R.; Wang, B.; Yu, C.; Wang, Y.; Dewey, C.M.; Shah, S.; Jiang, J.; Yu, G.
Gamma-secretase-regulated proteolysis of the Notch receptor by mitochondrial intermediate peptidase
J. Biol. Chem.
286
27447-27453
2011
Homo sapiens
Manually annotated by BRENDA team
Voegtle, F.N.; Prinz, C.; Kellermann, J.; Lottspeich, F.; Pfanner, N.; Meisinger, C.
Mitochondrial protein turnover: role of the precursor intermediate peptidase Oct1 in protein stabilization
Mol. Biol. Cell
22
2135-2143
2011
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Teixeira, P.; Glaser, E.
Processing peptidases in mitochondria and chloroplasts
Biochim. Biophys. Acta
1833
360-370
2013
Rattus norvegicus
Manually annotated by BRENDA team
Marcondes, M.; Alves, F.; Assis, D.; Hirata, I.; Juliano, L.; Oliveira, V.; Juliano, M.
Substrate specificity of mitochondrial intermediate peptidase analysed by a support-bound peptide library
FEBS Open Bio
5
429-436
2015
Homo sapiens
Manually annotated by BRENDA team
Carrie, C.; Venne, A.; Zahedi, R.; Soll, J.
Identification of cleavage sites and substrate proteins for two mitochondrial intermediate peptidases in Arabidopsis thaliana
J. Exp. Bot.
66
2691-2708
2015
Arabidopsis thaliana, Arabidopsis thaliana (W6HYK5)
Manually annotated by BRENDA team