3.4.24.59: mitochondrial intermediate peptidase
This is an abbreviated version!
For detailed information about mitochondrial intermediate peptidase, go to the full flat file.
Word Map on EC 3.4.24.59
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3.4.24.59
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mpp
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presequence
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oct1
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mating-type
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tetrapolarity
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schizophyllum
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homobasidiomycetes
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heterothallic
- 3.4.24.59
- mpp
- presequence
- oct1
-
mating-type
-
tetrapolarity
-
schizophyllum
- homobasidiomycetes
-
heterothallic
Reaction
release of an N-terminal octapeptide as second stage of processing of some proteins imported into the mitochondrion =
Synonyms
At1g09300, hMIP, Icp55, MIP, MIP1, MIPEP, mitochondrial intermediate peptidase, OCT1, octapeptidyl aminopeptidase 1, Proteinase, mitochondrial intermediate precursor-processing
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Natural Substrates Products
Natural Substrates Products on EC 3.4.24.59 - mitochondrial intermediate peptidase
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REACTION DIAGRAM
cytochrome c oxidase 4 precursor protein + H2O
mature cytochrome c oxidase + propeptide
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enzyme inhibition leads to prevention of the normal processing of the precursor of cytochrome c oxidase, i.e. COX, subunit 4 and induced COX degradation, overview
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Precursor proteins that have already been processed by mitochondrial processing peptidase + H2O
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serine hydroxymethyltransferase + H2O
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maturation of serine hydroxymethyltransferase by ICP55 involves breaking an aminoterminal diserine and appears to destabilize rather than stabilize this enzyme
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?
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required step for a subgroup of nuclear-encoded mitochondrial precursors
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Precursor proteins that have already been processed by mitochondrial processing peptidase + H2O
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Precursor proteins that have already been processed by mitochondrial processing peptidase + H2O
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a new component of the yeast mitochondrial import machinery
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