3.4.24.59: mitochondrial intermediate peptidase

This is an abbreviated version, for detailed information about mitochondrial intermediate peptidase, go to the full flat file.

Reaction

release of an N-terminal octapeptide as second stage of processing of some proteins imported into the mitochondrion =

Synonyms

hMIP, Icp55, MIP, MIP1, MIPEP, mitochondrial intermediate peptidase, OCT1, octapeptidyl aminopeptidase 1, Proteinase, mitochondrial intermediate precursor-processing

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.24 Metalloendopeptidases
                3.4.24.59 mitochondrial intermediate peptidase

Inhibitors

Inhibitors on EC 3.4.24.59 - mitochondrial intermediate peptidase

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INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1,10-phenanthroline
-
total inhibition at 10 mM
amastatin
-
-
bestatin
-
significant inhibition
captopril
-
-
DTT
-
inhibits enzymatic activity above to 0.1 mM
iodoacetamide
-
-
iodoacetic acid
-
-
JA-2
-
-
leupeptin
-
-
N-ethylmaleimide
-
-
p-hydroxymercuribenzoate
-
-
Pepstatin
-
-
Synthetic peptides
-
thiol-blocking agent
-
-
-
Thiol-blocking reagents
-
-
-
thiorphan
-
-
additional information
-