3.4.24.57: O-sialoglycoprotein endopeptidase
This is an abbreviated version!
For detailed information about O-sialoglycoprotein endopeptidase, go to the full flat file.
Word Map on EC 3.4.24.57
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3.4.24.57
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o-sialoglycoproteins
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pasteurella
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haemolytica
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neuraminidase
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psgl-1
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p-selectin
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ligand-1
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pasteurellosis
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sialomucins
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leukotoxin
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drug development
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medicine
- 3.4.24.57
- o-sialoglycoproteins
- pasteurella
- haemolytica
- neuraminidase
- psgl-1
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p-selectin
- ligand-1
- pasteurellosis
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sialomucins
- leukotoxin
- drug development
- medicine
Reaction
Hydrolysis of O-sialoglycoproteins; cleaves -Arg31-/-Asp- bond in glycophorin A. Does not cleave unglycosylated proteins, desialylated glycoproteins or glycoproteins that are only N-glycosylated =
Synonyms
Gcp, Glycophorin A proteinase, Glycoprotease, Glycoproteinase, O-sialoglycoprotein endopeptidase, OSE, OSGE, PG0778, PG1724, Proteinase, glyco-, Sialoglycoprotease, Sialoglycoproteinase
ECTree
3.4.24.57 O-sialoglycoprotein endopeptidaseAdvanced search results
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results (Substrates Products
Substrates Products on EC 3.4.24.57 - O-sialoglycoprotein endopeptidase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
Fetuin + H2O
N-terminal fragment of MW 45000 + a 20000 MW fragment at Val50 + C-terminal fragment at Val273 + C-terminal fragment at His287
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?
glycoprotein Ibalpha + H2O
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extracellular GPIbalpha is removed by O-sialoglycoprotein endopeptidase treatment
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?
surface CD43 + H2O
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OSGE improves T-cell function even in mice lacking CD43, showing that other glycoproteins must contribute to the OSGE effect on function, overview
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?
Cell-surface O-sialoglycoproteins + H2O
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no activity with glycoproteins which contain N-linked glycans but no O-sialo-glycans, leukocyte integrins, transferrin receptor, HLA class I and 8A3 Ag
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?
Cell-surface O-sialoglycoproteins + H2O
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CD34, CD43 (leukosialin), CD44 (hyaluronic acid receptor) and CD45 (leukocyte common Ag)
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?
Cell-surface O-sialoglycoproteins + H2O
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no activity with glycoproteins which contain N-linked glycans but no O-sialo-glycans, leukocyte integrins, transferrin receptor, HLA class I and 8A3 Ag
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?
Cell-surface O-sialoglycoproteins + H2O
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CD34, CD43 (leukosialin), CD44 (hyaluronic acid receptor) and CD45 (leukocyte common Ag)
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?
Glycophorin A + H2O
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?
additional information
?
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the enzyme removes the ligand for P-selectin from the surface of the myeloid cells, HL-60 cells and human neutrophils
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?
additional information
?
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the enzyme is immunogenic and may have a role in inducing a protective immune response against the pathogen Pasteurella haemolytica
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?
additional information
?
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removal of GPIbalpha N-terminal domain from human or mouse platelet GPIb-V-IX complex, overview
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?
additional information
?
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the enzyme is immunogenic and may have a role in inducing a protective immune response against the pathogen Pasteurella haemolytica
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?
additional information
?
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the enzyme removes the ligand for P-selectin from the surface of the myeloid cells, HL-60 cells and human neutrophils
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?
additional information
?
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increases alpha-CD3-induced Ca2+ responses in CD4+ T cells, and enhances cytokine production by CD4+ T cells, of both young and old mice, treatment with OSGE can enhance the expression of early activation markers in both WT and CD43 KO mice, overview
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?
additional information
?
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the enzyme is required for staphylococcal growth in the culture
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?
additional information
?
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Gcp is required for growth and is essential for bacteria, the essential Gcp is involved in the modification of substrates of murein hydrolases as well as in the regulation of expression and/or activity of some murein hydrolases, which, in turn, may play important roles in bacterial viability, Gcp may function independently from several key autolysins, e.g. Atl, LytM, and LytN, and regulators, e.g. ArlRS, Mgr/Rat, and CidA, overview
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?
