3.4.24.57: O-sialoglycoprotein endopeptidase

This is an abbreviated version!
For detailed information about O-sialoglycoprotein endopeptidase, go to the full flat file.

Reaction

Hydrolysis of O-sialoglycoproteins; cleaves -Arg31-/-Asp- bond in glycophorin A. Does not cleave unglycosylated proteins, desialylated glycoproteins or glycoproteins that are only N-glycosylated =

Synonyms

Gcp, Glycophorin A proteinase, Glycoprotease, Glycoproteinase, O-sialoglycoprotein endopeptidase, OSE, OSGE, PG0778, PG1724, Proteinase, glyco-, Sialoglycoprotease, Sialoglycoproteinase

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.24 Metalloendopeptidases

                3.4.24.57 O-sialoglycoprotein endopeptidase

Advanced search results

Do not include text mining results

Include results (more...)

Include results (more...)

Results	in table
1	Activating Compound
151	AA Sequence
2	Application
1	CAS Registry Number
1	Cloned(Commentary)
13	Disease/ Diagnostics
2	General Information
1	General Stability
3	Inhibitors
1	Ki Value [mM]
2	Localization
2	Metals/Ions
1	Molecular Weight [Da]
6	Natural Substrates/ Products (Substrates)
30	Organism
10	PDB ID
1	pH Optimum
1	pH Stability
1	Protein Variants
1	Purification (Commentary)
1	Reaction
1	Reaction Type
17	Reference
6	Source Tissue
1	Specific Activity [micromol/min/mg]
1	Storage Stability
31	Substrates and Products (Substrate)
14	Synonyms
2	Temperature Optimum [°C]

Engineering

print visible entries

print all entries

Go back to the abbreviated version
of the Enzyme Summary Page.

Engineering on EC 3.4.24.57 - O-sialoglycoprotein endopeptidase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

top print hide show all columns Go to Protein Variants Search

Please wait a moment until the data is sorted. This message will disappear when the data is sorted.

PROTEIN VARIANTS

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

additional information

Staphylococcus aureus

-

construction of a spacp-regulated gcp expression strain and a TetR-regulated gcp antisense expression strain, the down-regulation of gcp expression can effectively inhibit Triton X-100-induced lysis, eliminate penicillin- and vancomycin-caused cell lysis, and dramatically increase tolerance to hydrolases, overview

683606