3.4.24.55: pitrilysin

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For detailed information about pitrilysin, go to the full flat file.

Reaction

Preferential cleavage of -Tyr16-/- Leu- and -Phe25-/- Tyr-bonds of oxidized insulin B chain. Also acts on other substrates of less than 7 kDa such as insulin and glucagon =

Synonyms

EC 3.4.99.44, Escherichia coli protease III, Pitrilysin, ppBH4, Protease Pi, Proteinase Pi, Proteinase, Escherichia coli metallo-, Pi, PTR

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.24 Metalloendopeptidases

                3.4.24.55 pitrilysin

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Results	in table
5806	AA Sequence
1	CAS Registry Number
2	Cloned(Commentary)
47	Inhibitors
13	KM Value [mM]
8	Localization
15	Metals/Ions
10	Molecular Weight [Da]
15	Organism
1	PDB ID
3	pH Optimum
1	pI Value
16	Protein Variants
5	Purification (Commentary)
1	Reaction
1	Reaction Type
15	Reference
1	Specific Activity [micromol/min/mg]
1	Storage Stability
43	Substrates and Products (Substrate)
7	Subunits
9	Synonyms
3	Temperature Optimum [°C]
3	Temperature Stability [°C]
10	Turnover Number [1/s]

pH Optimum

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pH Optimum on EC 3.4.24.55 - pitrilysin

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pH OPTIMUM

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

6.8 - 7.2

Acinetobacter calcoaceticus

-

insulin

31309

7.5

Escherichia coli

-

4-dinitrophenyl)Lys-Leu-Asp-D-Lys

31307

8

Halalkalibacterium halodurans

-

activity in sodium phosphate buffer is 3- to 4fold higher than in veronal or Tris/HCl buffer

667795