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3.4.24.54: mucrolysin

This is an abbreviated version!
For detailed information about mucrolysin, go to the full flat file.

Word Map on EC 3.4.24.54

Reaction

Cleavage of Ser9-/-His, His10-/-Leu, Ala14-/-Leu, Leu15-/-Tyr and Tyr16-/-Leu bonds in insulin B chain =

Synonyms

Mucrotoxin A, Trimeresurus metalloendopeptidase A

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.24 Metalloendopeptidases
                3.4.24.54 mucrolysin

Substrates Products

Substrates Products on EC 3.4.24.54 - mucrolysin

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
Ala-Leu + H2O
?
show the reaction diagram
-
-
-
-
?
Ala-Leu + H2O
Alanine + leucine
show the reaction diagram
-
less effective than Gly-Pro, Leu-Gly or Gly-Leu
-
?
Dimethylcasein + H2O
?
show the reaction diagram
-
-
-
-
?
Fibrinogen + H2O
?
show the reaction diagram
-
-
-
-
?
Fibrinogen + H2O
Hydrolyzed fibrinogen
show the reaction diagram
-
hydrolyzes first the Aalpha and then the Bbeta chain
-
?
Gly-Gly + H2O
?
show the reaction diagram
-
-
-
-
?
Gly-Gly + H2O
Glycine + glycine
show the reaction diagram
-
less effective than Gly-Pro, Leu-Gly or Gly-Leu
-
?
Gly-Leu + H2O
Glycine + leucine
show the reaction diagram
-
-
-
?
Gly-Met + H2O
?
show the reaction diagram
-
-
-
-
?
Gly-Met + H2O
glycine + L-methionine
show the reaction diagram
-
less effective than Gly-Pro, Leu-Gly or Gly-Leu
-
-
?
Gly-Pro + H2O
?
show the reaction diagram
-
-
-
-
?
Gly-Pro + H2O
Glycine + proline
show the reaction diagram
-
-
-
?
Gly-Tyr + H2O
?
show the reaction diagram
-
-
-
-
?
Gly-Tyr + H2O
Glycine + tyrosine
show the reaction diagram
-
less effective than Gly-Pro, Leu-Gly or Gly-Leu
-
?
His-Leu + H2O
?
show the reaction diagram
-
-
-
-
?
His-Leu + H2O
Histidine + leucine
show the reaction diagram
-
less effective than Gly-Pro, Leu-Gly or Gly-Leu
-
?
insulin B chain + H2O
?
show the reaction diagram
-
hydrolyzes Aalpha chain first and then the Bbeta chain
-
-
?
Leu-Gly + H2O
?
show the reaction diagram
-
-
-
-
?
Leu-Gly + H2O
Leucine + glycine
show the reaction diagram
-
-
-
?
Leu-Tyr + H2O
?
show the reaction diagram
-
-
-
-
?
Leu-Tyr + H2O
Leucine + tyrosine
show the reaction diagram
-
less effective than Gly-Pro, Leu-Gly or Gly-Leu
-
?
Oxidized insulin B-chain + H2O
Hydrolyzed insulin B-chain
show the reaction diagram
-
cleavage at Ser9-His10, His10-Leu11, Ala14-Leu15, Leu15-Tyr16 and Tyr16-Leu17
-
?
Tyr-Leu + H2O
?
show the reaction diagram
-
-
-
-
?
Tyr-Leu + H2O
Tyrosine + leucine
show the reaction diagram
-
less effective than Gly-Pro, Leu-Gly or Gly-Leu
-
?
additional information
?
-