3.4.24.52: trimerelysin I

This is an abbreviated version!
For detailed information about trimerelysin I, go to the full flat file.

Reaction

Cleavage of only two bonds His10-/-Leu and Ala14-/-Leu in the insulin B chain =

Synonyms

Hemorrhagic metalloproteinase HR1A, Hemorrhagic proteinase HR1A, HR1A, Metalloproteinase HR1A, metalloproteinase HR1b, Trimeresurus metalloendopeptidase I

ECTree

3 Hydrolases

3.4 Acting on peptide bonds (peptidases)

3.4.24 Metalloendopeptidases

3.4.24.52 trimerelysin I

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Results	in table
7	AA Sequence
1	Application
1	CAS Registry Number
3	Inhibitors
5	KM Value [mM]
1	Localization
3	Metals/Ions
6	Molecular Weight [Da]
4	Natural Substrates/ Products (Substrates)
7	Organism
3	pH Optimum
1	pH Range
1	Posttranslational Modification
2	Purification (Commentary)
1	Reaction
1	Reaction Type
7	Reference
7	Source Tissue
1	Specific Activity [micromol/min/mg]
22	Substrates and Products (Substrate)
3	Subunits
8	Synonyms
3	Temperature Optimum [°C]

Inhibitors

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Inhibitors on EC 3.4.24.52 - trimerelysin I

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1,10-phenanthroline

Protobothrops flavoviridis

inhibits the hemorrhagic and proteolytic activity of HR1A

668854

EDTA

Protobothrops flavoviridis

inhibits the hemorrhagic and proteolytic activity of HR1A

668854

additional information

Protobothrops flavoviridis

specific monoclonal human antibodies HuMAbs neutralize the HR1a, determined by in vitro neutralization assay and by neutralization of the hemorrhagic activity, overview, from hybridoma from the fusion of SP2/0-Ag14 myeloma cells and spleen cells from KM mice immunized with purified HR1a, epitope mapping, overview

684093