3.4.24.51: ophiolysin
This is an abbreviated version!
For detailed information about ophiolysin, go to the full flat file.
Reaction
Cleavage of Asn3-/-Gln, Gln4-/-His, His10-/-Leu, Ala14-/-Leu, and Tyr16-/-Leu in insulin B chain =
Synonyms
ohagin, Ophiophagus metalloendopeptidase
ECTree
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Substrates Products
Substrates Products on EC 3.4.24.51 - ophiolysin
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REACTION DIAGRAM
insulin B chain + H2O
Phe-Val-Asn + Gln + HLCGSH + LVEA + Leu-Tyr + LVCGERGFFYTPKA
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Insulin B-chain + H2O
Hydrolyzed insulin B-chain
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cleavage of Asn3-Gln, Gln4-His, His10-Leu, Ala14-Leu and Tyr16-Leu
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human substrate, specific degradation of the alpha-chain, no activity with beta-chain and gamma-chain, the enzyme has a fibrinogenolytic activity and hemorrhagic activity in mice, overview
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Fibrinogen + H2O
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specific degradation of the alpha-chain of the human substrate, while the beta- and gamma-chains are not hydrolyzed
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the enzyme inhibits platelet aggregation induced by ADP, TMVA, and stejnulxin
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additional information
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the enzyme inhibits platelet aggregation induced by ADP, TMVA, and stejnulxin
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