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3.4.24.51: ophiolysin

This is an abbreviated version!
For detailed information about ophiolysin, go to the full flat file.

Reaction

Cleavage of Asn3-/-Gln, Gln4-/-His, His10-/-Leu, Ala14-/-Leu, and Tyr16-/-Leu in insulin B chain =

Synonyms

ohagin, Ophiophagus metalloendopeptidase

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.24 Metalloendopeptidases
                3.4.24.51 ophiolysin

Substrates Products

Substrates Products on EC 3.4.24.51 - ophiolysin

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
casein + H2O
?
show the reaction diagram
-
-
-
-
?
Fibrinogen + H2O
?
show the reaction diagram
insulin B chain + H2O
Phe-Val-Asn + Gln + HLCGSH + LVEA + Leu-Tyr + LVCGERGFFYTPKA
show the reaction diagram
-
-
-
-
?
Insulin B-chain + H2O
Hydrolyzed insulin B-chain
show the reaction diagram
-
cleavage of Asn3-Gln, Gln4-His, His10-Leu, Ala14-Leu and Tyr16-Leu
-
?
additional information
?
-