3.4.24.49: bothropasin
This is an abbreviated version!
For detailed information about bothropasin, go to the full flat file.
Word Map on EC 3.4.24.49
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3.4.24.49
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hemorrhagic
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metalloproteinases
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svmps
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envenom
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snakebite
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disintegrins
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disintegrin-like
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jararhagin
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antivenoms
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atrox
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viperid
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asper
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fibrinogenolytic
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trimeresurus
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agkistrodon
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flavoviridis
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echis
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atrolysin
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protobothrops
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pitviper
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reprolysins
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ammodytes
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adamalysins
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medicine
- 3.4.24.49
-
hemorrhagic
- metalloproteinases
-
svmps
-
envenom
-
snakebite
-
disintegrins
-
disintegrin-like
- jararhagin
- antivenoms
- atrox
-
viperid
- asper
-
fibrinogenolytic
- trimeresurus
-
agkistrodon
- flavoviridis
- echis
- atrolysin
- protobothrops
-
pitviper
-
reprolysins
- ammodytes
- adamalysins
- medicine
Reaction
Cleavage of His5-/-Leu, His10-/-Leu, Ala14-/-Leu, Tyr16-/-Leu and Phe24-/-Phe in insulin B chain =
Synonyms
Bothrops jararaca snake venom metalloproteinase, HF3, Proteinase, Bothrops jararaca venom metallo-, snake venom metalloproteinase, SVMP
ECTree
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Natural Substrates Products on EC 3.4.24.49 - bothropasin
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REACTION DIAGRAM
Fibrin + H2O
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the enzyme specifically cleaves the alpha-polymer and alpha-chain of the fibrin molecule, in contrast gamma-gamma dimer and beta-chain of the fibrin are found to be resistant to the enzyme
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comparison of hemorrhagic, caseinolytic and fibrinogenolytic activities of metalloproteinases HF3, bothropasin, the DC protein and metalloproteinase BJ-PI. Hemorrhagic activity of bothropasin is 0.006 mg to produce a hemorrhagic area of 1 cm2. Fibrinogenolytic activity of bothropasin is 9.8 units/mg
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additional information
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comparison of hemorrhagic, caseinolytic and fibrinogenolytic activities of metalloproteinases HF3, bothropasin, the DC protein and metalloproteinase BJ-PI. Hemorrhagic activity of bothropasin is 0.006 mg to produce a hemorrhagic area of 1 cm2. Fibrinogenolytic activity of bothropasin is 9.8 units/mg
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