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3.4.24.49: bothropasin

This is an abbreviated version!
For detailed information about bothropasin, go to the full flat file.

Word Map on EC 3.4.24.49

Reaction

Cleavage of His5-/-Leu, His10-/-Leu, Ala14-/-Leu, Tyr16-/-Leu and Phe24-/-Phe in insulin B chain =

Synonyms

Bothrops jararaca snake venom metalloproteinase, HF3, Proteinase, Bothrops jararaca venom metallo-, snake venom metalloproteinase, SVMP

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.24 Metalloendopeptidases
                3.4.24.49 bothropasin

Natural Substrates Products

Natural Substrates Products on EC 3.4.24.49 - bothropasin

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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
Fibrin + H2O
?
show the reaction diagram
the enzyme specifically cleaves the alpha-polymer and alpha-chain of the fibrin molecule, in contrast gamma-gamma dimer and beta-chain of the fibrin are found to be resistant to the enzyme
-
-
?
Fibrinogen + H2O
?
show the reaction diagram
-
-
-
?
Fibronectin + H2O
?
show the reaction diagram
additional information
?
-