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3.4.24.46: adamalysin

This is an abbreviated version!
For detailed information about adamalysin, go to the full flat file.

Word Map on EC 3.4.24.46

Reaction

Cleavage of Phe1-/-Val, His5-/-Leu, His10-/-Leu, Ala14-/-Leu, Leu15-/-Tyr, and Tyr16-/-Leu of insulin B chain =

Synonyms

Adamalysin II, Crotalus adamanteus metalloendopeptidase, Crotalus adamanteus venom proteinase II, metargidin, Proteinase I and II, Proteinase, Crotalus adamanteus venom, II

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.24 Metalloendopeptidases
                3.4.24.46 adamalysin

Reference

Reference on EC 3.4.24.46 - adamalysin

Please use the Reference Search for a specific query.
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Bode, W.; Gomis-Ruth, F.X.; Stöckler, W.
Astacins, serralysins, snake venom and matrix metalloproteinases exhibit identical zinc-binding environments (HEXXHXXGXXH and Met-turn) and topologies and should be grouped into a common family, the metzincins
FEBS Lett.
331
134-140
1993
Crotalus adamanteus
Manually annotated by BRENDA team
Kurecki, T.; Laskowski, M.; Kress, L.F.
Purification and some properties of two proteinases from Crotalus adamanteus venom that inactivate human alpha 1-proteinase inhibitor
J. Biol. Chem.
253
8340-8345
1978
Crotalus adamanteus
Manually annotated by BRENDA team
Kress, L.F.; Kurecki, T.
Studies on the complex between human alpha 2-macroglobulin and Crotalus adamanteus proteinase II. Release of active proteinase from the complex
Biochim. Biophys. Acta
613
469-475
1980
Crotalus adamanteus
Manually annotated by BRENDA team
Kress, L.F.; Catanese, J.J.
Identification of the cleavage sites resulting from enzymatic inactivation of human antithrombin III by Crotalus adamanteus proteinase II in the the presence and absence of heparin
Biochemistry
20
7432-7438
1981
Crotalus adamanteus
Manually annotated by BRENDA team
Grams, F.; Huber, R.; Kress, L.F.; Moroder, L.; Bode, W.
Activation of snake venom metalloproteinases by a cysteine switch-like mechanism
FEBS Lett.
335
76-80
1993
Crotalus adamanteus
Manually annotated by BRENDA team
Gomis-Ruth, F.X.; Kress, L.F.; Kellermann, J.; Mayr, I.; Lee, X.; Huber, R.; Bode, W.
Refined 2.0 A X-ray crystal structure of the snake venom zinc-endopeptidase adamalysin II. Primary and tertiary structure determination, refinement, molecular structure and comparison with astacin, collagenase and thermolysin
J. Mol. Biol.
239
513-544
1994
Crotalus adamanteus
Manually annotated by BRENDA team
Bode, W.; Kress, L.F.
Crystallization and preliminary x-ray diffraction data of proteinase II from Crotalus adamanteus (eastern diamond rattlesnake)
FEBS Lett.
154
274-276
1983
Crotalus adamanteus
-
Manually annotated by BRENDA team
D'Alessio, S.; Gallina, C.; Gavuzzo, E.; Giordano, C.; Gorini, B.; Mazza, F.; Paradisi, M.P.; Panini, G.; Pochetti, G.; Sella, A.
Inhibition of adamalysin II and MMPs by phosphonate analogues of snake venom peptides
Bioorg. Med. Chem.
7
389-394
1999
Crotalus adamanteus
Manually annotated by BRENDA team
Cirilli, M.; Gallina, C.; Gavuzzo, E.; Giordano, C.; Gomis-Ruth, F.X.; Gorini, B.; Kress, L.F.; Mazza, F.; Paradisi, M.P.; Pochetti, G.; Politi, V.
2 angstrom X-ray structure of adamalysin II complexed with a peptide phosphonate inhibitor adopting a retro-binding mode
FEBS Lett.
418
319-322
1997
Crotalus adamanteus
Manually annotated by BRENDA team
Gomis-Rueth, F.X.; Meyer, E.F.; Kress, L.F.; Politi, V.
Structures of adamalysin II with peptidic inhibitors. Implications for the design of tumor necrosis factor alpha convertase inhibitors
Protein Sci.
7
283-292
1998
Crotalus adamanteus
Manually annotated by BRENDA team
Trochon-Joseph, V.; Martel-Renoir, D.; Mir, L.M.; Thomaidis, A.; Opolon, P.; Connault, E.; Li, H.; Grenet, C.; Fauvel-Lafeve, F.; Soria, J.; Legrand, C.; Soria, C.; Perricaudet, M.; Lu, H.
Evidence of antiangiogenic and antimetastatic activities of the recombinant disintegrin domain of metargidin
Cancer Res.
64
2062-2069
2004
Homo sapiens
Manually annotated by BRENDA team