3.4.24.46: adamalysin
This is an abbreviated version!
For detailed information about adamalysin, go to the full flat file.
Word Map on EC 3.4.24.46
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3.4.24.46
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metalloproteinases
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disintegrin
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snake
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metzincins
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electrotransfer
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adam15
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astacins
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matrixins
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alpha-secretase
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met-turn
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hexxhxxgxxh
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medicine
- 3.4.24.46
- metalloproteinases
-
disintegrin
-
snake
-
metzincins
-
electrotransfer
- adam15
- astacins
- matrixins
- alpha-secretase
-
met-turn
-
hexxhxxgxxh
- medicine
Reaction
Cleavage of Phe1-/-Val, His5-/-Leu, His10-/-Leu, Ala14-/-Leu, Leu15-/-Tyr, and Tyr16-/-Leu of insulin B chain =
Synonyms
Adamalysin II, Crotalus adamanteus metalloendopeptidase, Crotalus adamanteus venom proteinase II, metargidin, Proteinase I and II, Proteinase, Crotalus adamanteus venom, II
ECTree
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Disease
Disease on EC 3.4.24.46 - adamalysin
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Adenocarcinoma
Inhibitory antibodies against endopeptidase activity of human adamalysin 19.
Carcinoma
Metargidin, a membrane-anchored metalloprotease-disintegrin protein with an RGD integrin binding sequence.
Melanoma
Biological Properties of Melanoma and Endothelial Cells after Plasmid AMEP Gene Electrotransfer Depend on Integrin Quantity on Cells.
Melanoma
Gene electrotransfer of plasmid AMEP, an integrin-targeted therapy, has antitumor and antiangiogenic action in murine B16 melanoma.
Melanoma
Gene Electrotransfer of Plasmid Antiangiogenic Metargidin Peptide (AMEP) in Disseminated Melanoma: Safety and Efficacy Results of a Phase I First-in-Man Study.
Neoplasms
Alternative splicing of ADAM15 regulates its interactions with cellular SH3 proteins.
Neoplasms
Characterization of growth factor-induced serine phosphorylation of tumor necrosis factor-alpha converting enzyme and of an alternatively translated polypeptide.
Neoplasms
P2Y2 nucleotide receptors mediate metalloprotease-dependent phosphorylation of epidermal growth factor receptor and ErbB3 in human salivary gland cells.
Neoplasms
Regulation of tumor necrosis factor-alpha and tumor necrosis factor converting enzyme in human osteoarthritis.
Neoplasms
Structures of adamalysin II with peptidic inhibitors. Implications for the design of tumor necrosis factor alpha convertase inhibitors.
Neoplasms
The secretases that cleave angiotensin converting enzyme and the amyloid precursor protein are distinct from tumour necrosis factor-alpha convertase.
Oligodendroglioma
Microvesicles shed by oligodendroglioma cells and rheumatoid synovial fibroblasts contain aggrecanase activity.
Osteoarthritis
Interleukin 13 (IL-13)-regulated expression of the chondroprotective metalloproteinase ADAM15 is reduced in aging cartilage.
Osteoarthritis
Regulation of tumor necrosis factor-alpha and tumor necrosis factor converting enzyme in human osteoarthritis.
Purpura, Thrombotic Thrombocytopenic
Complement activation in diseases presenting with thrombotic microangiopathy.
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