3.4.24.45: atrolysin F
This is an abbreviated version!
For detailed information about atrolysin F, go to the full flat file.
Word Map on EC 3.4.24.45
Reaction
Cleavage of Val2-/-Asn, Gln4-/-His, Leu6-/-Cys, His10-/-Leu, Ala14-/-Leu and Tyr16-/-Leu bonds in insulin B chain =
Synonyms
Crotalus atrox metalloendopeptidase f, Hemorrhagic toxin f, HT-f
ECTree
3.4.24.45 atrolysin FAdvanced search results
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Substrates Products on EC 3.4.24.45 - atrolysin F
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
Basement membranes surrounding capillaries + H2O
?
-
involved in disruption of capillary membranes
-
-
?
Basement membranes surrounding capillaries + H2O
?
-
produces not only local hemorrhage in skin and muscle, but also systemic hemorrhage in internal organs such as intestine, kidney, lung, heart and liver
-
-
?
Basement membranes surrounding capillaries + H2O
?
-
together with atrolysin A member of the class P-III hemorrhagic toxins
-
-
?
Fibrinogen + H2O
Hydrolyzed fibrinogen
-
no coagulation
non-clottable products
?
Fibrinogen + H2O
Hydrolyzed fibrinogen
-
cleaves gamma-chain, Aalpha and Bbeta-chains remain intact
-
-
?
Fibrinogen + H2O
Hydrolyzed fibrinogen
-
cleaves gamma-chain, Aalpha and Bbeta-chains remain intact
non-clottable products
?
Oxidized insulin B-chain + H2O
Hydrolyzed oxidized insulin B-chain
-
cleaves Val2-Asn3, Gln4-His5, Leu6-Cys7, H10-Leu11, Ala14-Leu15, Tyr16-Leu17 bonds
several peptides
?
additional information
?
-
-
no hydrolysis of tosyl-L-Arg methyl ester or N-benzoyl-L-Arg ethyl ester
-
-
?
