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3.4.24.44: atrolysin E

This is an abbreviated version!
For detailed information about atrolysin E, go to the full flat file.

Word Map on EC 3.4.24.44

Reaction

Cleavage of Asn3-/-Gln, Ser9-/-His and Ala14-/-Leu bonds in insulin B chain and Tyr14-/-Gln and Thr8-/-Ser in A chain. Cleaves type IV collagen at Ala73-/-Gln in alpha1(IV) and at Gly7-/-Leu in alpha2(IV) =

Synonyms

atrolysin E/D, Crotalus atrox metalloendopeptidase e, Hemorrhagic toxin e, HT-e

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.24 Metalloendopeptidases
                3.4.24.44 atrolysin E

Substrates Products

Substrates Products on EC 3.4.24.44 - atrolysin E

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
Basement membrane preparation + H2O
Soluble peptides
show the reaction diagram
basement membrane preperation from Engel-breth-Holm-Swarm tumor + H2O
?
show the reaction diagram
-
great proteolytic activity
-
-
?
Basement membranes surrounding capillaries + H2O
?
show the reaction diagram
collagen type IV + H2O
?
show the reaction diagram
-
-
-
-
?
Collagen type IV alphaI(IV) chains + H2O
?
show the reaction diagram
-
basement membrane component, cleavage at Ala219-Gln220
-
-
?
Collagen type IV alphaII(IV) chain + H2O
?
show the reaction diagram
-
basement membrane component, cleavage at Thr228-Leu229
-
-
?
Dimethylcasein + H2O
?
show the reaction diagram
-
-
-
-
?
Dimethylhemoglobin + H2O
?
show the reaction diagram
-
-
-
-
?
Fibrinogen + H2O
?
show the reaction diagram
-
rapid cleavage of the Aalpha chain followed by the Bbeta and gamma chains
-
-
?
Fibrinogen + H2O
Hydrolyzed fibrinogen
show the reaction diagram
Fibronectin + H2O
Hydrolyzed fibronectin
show the reaction diagram
-
-
lower MW fragments
?
Gelatin of collagen type I + H2O
?
show the reaction diagram
-
-
-
-
?
Gelatin of collagen type II + H2O
?
show the reaction diagram
-
-
-
-
?
Gelatin of collagen type III + H2O
?
show the reaction diagram
-
-
-
-
?
Gelatin of collagen type V + H2O
?
show the reaction diagram
-
-
-
-
?
Human alpha2-macroglobulin + H2O
?
show the reaction diagram
-
cleavage at Val689-Met690 and Gly693-His694
-
-
?
Laminin + H2O
?
show the reaction diagram
Laminin/nidogen complex + H2O
?
show the reaction diagram
-
cleavage at positions 322, 336, 351, 840 and 953
-
-
?
Nidogen + H2O
?
show the reaction diagram
o-aminobenzoyl-Ala-Gly-Leu-Ala-nitrobenzylamide + H2O
?
show the reaction diagram
-
-
-
-
?
Oxidized insulin A-chain + H2O
Hydrolyzed oxidized insulin A-chain
show the reaction diagram
-
rapid cleavage at Tyr14-Gln15, more slowly at Ala8-Ser9, kinetics
peptides (Gln15-Asn21) + (Gly1-Tyr14) + (Ser9-Tyr14) + (Gly1-Ala8)
?
Oxidized insulin B-chain + H2O
?
show the reaction diagram
-
-
-
-
?
Oxidized insulin B-chain + H2O
Hydrolyzed oxidized insulin B-chain
show the reaction diagram
additional information
?
-