3.4.24.43: atroxase

This is an abbreviated version!
For detailed information about atroxase, go to the full flat file.

Cleavage of His5-/-Leu, Ser9-/-His, His10-/-Leu, Ala14-/-Leu and Tyr16-/-Leu of insulin B chain =

Atroxase (Crotalus atrox), Crotalus atrox fibrinogenase, Crotalus atrox nonhemorrhagic metalloendopeptidase

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Results	in table
1	AA Sequence
1	Application
2	CAS Registry Number
1	Cloned(Commentary)
3	Inhibitors
4	Metals/Ions
4	Molecular Weight [Da]
1	Natural Substrates/ Products (Substrates)
3	Organism
2	pH Optimum
1	pH Stability
2	Purification (Commentary)
1	Reaction
1	Reaction Type
3	Reference
3	Source Tissue
1	Specific Activity [micromol/min/mg]
11	Substrates and Products (Substrate)
1	Subunits
3	Synonyms
3	Temperature Optimum [°C]
1	Temperature Stability [°C]

Substrates Products on EC 3.4.24.43 - atroxase

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Dimethylcasein + H2O

Fibrin + H2O

both alpha and beta chains hydrolyzed, but the gamma-gamma chain not affected

Fibrinogen + H2O

Aalpha and Bbeta chains readily hydrolyzed, but gamma chain resistant to hydrolysis

Human fibrinogen + H2O

Oxidized insulin B-chain

cleavage of His5-Leu6, Ser9-His10, His10-Leu11, Ala14-Leu15, Tyr16-Leu17

Oxidized insulin B-chain + H2O

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