3.4.24.41: atrolysin B

This is an abbreviated version!
For detailed information about atrolysin B, go to the full flat file.

Reaction

Cleavage of His5-/-Leu, His10-/-Leu, Ala14-/-Leu, Tyr16-/-Leu and Gly23-/-Phe of insulin B chain; identical to the cleavage of insulin B chain by atrolysin C. Also cleaves -/-Ser bonds in glucagon =

Synonyms

Crotalus atrox metalloendopeptidase b, Hemorrhagic toxin b, hemorrhagic toxin b metalloproteinase, HT-b

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.24 Metalloendopeptidases

                3.4.24.41 atrolysin B

Advanced search results

Do not include text mining results

Include results (more...)

Include results (more...)

Results	in table
2	AA Sequence
1	Application
1	CAS Registry Number
1	Cloned(Commentary)
11	Inhibitors
3	Metals/Ions
6	Molecular Weight [Da]
1	Natural Substrates/ Products (Substrates)
5	Organism
2	pH Optimum
1	Posttranslational Modification
3	Purification (Commentary)
1	Reaction
1	Reaction Type
5	Reference
4	Source Tissue
20	Substrates and Products (Substrate)
3	Subunits
6	Synonyms
1	Temperature Optimum [°C]
5	Turnover Number [1/s]

Natural Substrates Products

print visible entries

print all entries

Go back to the abbreviated version
of the Enzyme Summary Page.

Natural Substrates Products on EC 3.4.24.41 - atrolysin B

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

top print hide show all columns Go to Natural Substrate Search

Please wait a moment until the data is sorted. This message will disappear when the data is sorted.

NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

Basement membranes surrounding capillaries + H2O

?

Crotalus atrox

-

involved in disruption of capillary membranes, together with atrolysins C and E member of the class P-I hemorrhagic toxins, most abundant hemorrhagic toxin in the venom

31259

-

-

?