3.4.24.41: atrolysin B
This is an abbreviated version!
For detailed information about atrolysin B, go to the full flat file.
Reaction
Cleavage of His5-/-Leu, His10-/-Leu, Ala14-/-Leu, Tyr16-/-Leu and Gly23-/-Phe of insulin B chain; identical to the cleavage of insulin B chain by atrolysin C. Also cleaves -/-Ser bonds in glucagon =
Synonyms
Crotalus atrox metalloendopeptidase b, Hemorrhagic toxin b, hemorrhagic toxin b metalloproteinase, HT-b
ECTree
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Inhibitors
Inhibitors on EC 3.4.24.41 - atrolysin B
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rosmarinic acid
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isolated from a methanolic extract of Argusia argentea (Boraginaceae) which significantly inhibits snake venom-induced hemorrhage; significantly inhibits the hemorrhagic effect of crude venom of Crotalus atrox and others as well as snake venom metalloproteinase HT-b