3.4.24.40: serralysin

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For detailed information about serralysin, go to the full flat file.

Reaction

Preferential cleavage of bonds with hydrophobic residues in P1' =

Synonyms

aeruginolysin, Alkaline protease, AMP-P, AP, APR, AprA, AprX, arazyme, calcium-regulated alkaline protease, DR2310 protease, Escherichia freundii proteinase, Extracellular metalloproteinase, LupA, More, protease B, protease C, protease I, Proteinase, Serratia marcescens metallo-, PrtA, PrtA metalloprotease, PrtC, pseudomonal serralysin, Pseudomonas aeruginosa alk. protease, Pseudomonas aeruginosa alkaline protease, Pseudomonas aeruginosa alkaline proteinase, Pseudomonas alkaline protease, psychrophilic alkaline metalloprotease, serralysin, serralysin-like metalloprotease, Serratia marcescens extracellular proteinase, Serratia marcescens metalloprotease, Serratia marcescens metalloproteinase, SlpB, SMP, thermoalkaline protease, thermostable alkaline protease, zinc proteinase

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.24 Metalloendopeptidases

                3.4.24.40 serralysin

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Results	in table
1	Activating Compound
1130	AA Sequence
4	Application
1	CAS Registry Number
16	Cloned(Commentary)
9	Crystallization (Commentary)
2	Expression
8	General Information
2	General Stability
176	Inhibitors
36	kcat/KM [mM/s]
12	Ki Value [mM]
77	KM Value [mM]
37	Localization
89	Metals/Ions
49	Molecular Weight [Da]
11	Natural Substrates/ Products (Substrates)
74	Organism
13	PDB ID
34	pH Optimum
9	pH Range
12	pH Stability
3	pI Value
1	Posttranslational Modification
13	Protein Variants
29	Purification (Commentary)
1	Reaction
1	Reaction Type
72	Reference
1	Renatured (Commentary)
12	Source Tissue
10	Specific Activity [micromol/min/mg]
4	Storage Stability
261	Substrates and Products (Substrate)
19	Subunits
64	Synonyms
15	Temperature Optimum [°C]
3	Temperature Range [°C]
25	Temperature Stability [°C]
48	Turnover Number [1/s]

pH Range

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pH Range on EC 3.4.24.40 - serralysin

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pH RANGE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

4.5 - 9.5

Deinococcus radiodurans

-

-

696410

5.2 - 8.8

Pseudomonas sp.

-

more than 90% of maximal activity between pH 6.0 and 8.8, 44% activity at pH 5.2

734494

6 - 10

Pseudomonas aeruginosa

-

about half-maximal activity at pH 6 and about 80% of maximal activity at pH 10, casein as substrate, about 75% of maximal activity at pH 6 and about 60% of maximal activity at pH 10, egg white albumin as substrate

31249

6 - 8

Pseudomonas fluorescens

-

in absence and presence of Co2+

665417

6.5 - 10

Pseudomonas aeruginosa

-

about half-maximal activity at pH 6.5 and about 65% of maximal activity at pH 10, hemoglobin as substrate

31249

7 - 11

Serratia marcescens

-

more than 50% activity between pH 7.0 and 11.0

733986

7.2 - 10.8

Citrobacter freundii

-

about half-maximal activity at pH 7.2 and 10.8

31243

7.5 - 10.6

Serratia marcescens

-

-

31245

8 - 9

Pseudomonas fluorescens

-

with substrate t-butyloxycarbonyl-Arg-Val-Arg-Arg-4-methylcoumaryl-7-amide in the presence of Co2+

665417