3.4.24.39: deuterolysin
This is an abbreviated version!
For detailed information about deuterolysin, go to the full flat file.
Word Map on EC 3.4.24.39
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3.4.24.39
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gtpase-activating
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3.4.24.4
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metalloendopeptidase
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salmonicida
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achromogenes
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arf6
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invadopodia
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podosomes
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arfgap
- 3.4.24.39
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gtpase-activating
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3.4.24.4
- metalloendopeptidase
- salmonicida
- achromogenes
- arf6
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invadopodia
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podosomes
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arfgap
Reaction
Preferential cleavage of bonds with hydrophobic residues in P1'; also Asn3-/-Gln and Gly8-/-Ser bonds in insulin B chain =
Synonyms
Acid metalloproteinase, AsaP1, aspzincin, DeuA, deuB, Deuterolysin, EC 3.4.24.4, Mep-1 like, Mep-2 like, Mep-2-like, Mep1-like, Mep2, Mep2-like, Mep3, Mep3-like, Mep4, Mep4-1 like, Mep4-like, Mep5, Mep5-like, Mep6, Mep6-like, Mep7, Mep7-like, Mep8, Mep8-like, Microbial neutral proteinase II, Neutral proteinase II, NPII, Penicillium roqueforti metalloproteinase, Penicillium roqueforti protease II, Proteinase, Penicillium roqueforti metallo-
ECTree
Advanced search results
Substrates Products
Substrates Products on EC 3.4.24.39 - deuterolysin
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REACTION DIAGRAM
alpha-casein + H2O
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degradation with low specific activity
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-
?
benzyloxycarbonyl-Val-Lys-Met-7-amido-4-methylcoumarin + H2O
?
second-best substrate
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-
?
beta-lactoglobulin + H2O
?
degradation with low specific activity
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-
?
Boc-Arg-Val-Arg-Arg-7-amido-4-methylcoumarin + H2O
?
most favorable substrate
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-
?
carboxybenzyl-Gly-Phe amide + H2O
carboxybenzyl-Gly + Phe amide
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-
-
?
clupeine + H2O
?
degradation with high specific activity
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-
?
N-butoxycarbonyl-arginyl-valyl-arginyl-arginyl-4-methylcoumarin-7-amide + H2O
?
-
-
-
?
N-butoxycarbonyl-Leu-Arg-Arg-4-methylcoumarin-7-amide + H2O
?
-
-
-
?
N-butoxycarbonyl-Leu-Lys-Arg-4-methylcoumarin-7-amide + H2O
?
-
-
-
?
salmine + H2O
?
degradation with high specific activity
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-
?
Boc-Val-Leu-Lys-7-amido-4-methylcoumarin + H2O
?
degradation with low specific activity
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-
?
casein + H2O
?
degradation with low specific activity
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-
?
Fibrin + H2O
?
degradation with low specific activity
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-
?
Glt-Ala-Ala-Phe-7-amido-4-methylcoumarin + H2O
?
degradation with low specific activity
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-
?
?
degradation with high specific activity
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-
?
histone + H2O
?
degradation with high specific activity
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-
?
?
degradation with low specific activity
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-
?
ovalbumin + H2O
?
degradation with low specific activity
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-
?
Oxidized insulin B-chain + H2O
?
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cleavage at: Phe1-Val2, Asn3-Gln4, Gln4-His5, Gly8-Ser9, Ser9-His10, His10-Leu11, Leu11-Val12, Glu13-Ala14, Ala14-Leu15, Tyr16-Leu17, Arg22-Gly23, Tyr26-Thr27
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-
?
Suc-Leu-Val-Tyr-7-amido-4-methylcoumarin + H2O
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degradation with low specific activity
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-
?
?
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neither aminopeptidase nor carboxypeptidase activity
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-
?
additional information
?
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almost no hydrolysis toward mono or certain dibasic peptide 4-methylcoumarin-7-amides like N-butoxycarbonyl-Leu-Ser-Thr-Arg-4-methylcoumarin-7-amide, N-butoxycarbonyl-Ile-Glu-Gly-Arg-4-methylcoumarin-7-amide, N-butoxycarbonyl-Ala-Gly-Pro-Arg-4-methylcoumarin-7-amide, N-butoxycarbonyl-Gln-Gly-Arg-4-methylcoumarin-7-amide, N-butoxycarbonyl-Leu-Gly-Arg-4-methylcoumarin-7-amide, N-butoxycarbonyl-Leu-Thr-Arg-4-methylcoumarin-7-amide, Z-Phe-Arg-4-methylcoumarin-7-amide, Arg-4-methylcoumarin-7-amide, Lys-4-methylcoumarin-7-amide, N-butoxycarbonyl-Gly-Arg-Arg-4-methylcoumarin-7-amide, N-butoxycarbonyl-Gln-Arg-Arg-4-methylcoumarin-7-amide, and N-butoxycarbonyl-Gln-Lys-Lys-4-methylcoumarin-7-amide
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?
additional information
?
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DeuA can not digest elastin and collagen. No hydrolysis of benzyloxycarbonyl-Val-Lys-Met-7-amido-4-methylcoumarin, benzyloxycarbonyl-Leu-Arg-7-amido-4-methylcoumarin, benzyloxycarbonyl-Val-Val-Arg-7-amido-4-methylcoumarin and Suc-Gly-Pro-7-amido-4-methylcoumarin. DeuA and DeuB have similar digestion property against the protein substrates, but DeuB has a wider substrate specificity compared with DeuA
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-
?
additional information
?
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DeuA can not digest elastin and collagen. No hydrolysis of benzyloxycarbonyl-Val-Lys-Met-7-amido-4-methylcoumarin, benzyloxycarbonyl-Leu-Arg-7-amido-4-methylcoumarin, benzyloxycarbonyl-Val-Val-Arg-7-amido-4-methylcoumarin and Suc-Gly-Pro-7-amido-4-methylcoumarin. DeuA and DeuB have similar digestion property against the protein substrates, but DeuB has a wider substrate specificity compared with DeuA
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-
?
additional information
?
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-
DeuA can not digest elastin and collagen. No hydrolysis of benzyloxycarbonyl-Val-Lys-Met-7-amido-4-methylcoumarin, benzyloxycarbonyl-Leu-Arg-7-amido-4-methylcoumarin, benzyloxycarbonyl-Val-Val-Arg-7-amido-4-methylcoumarin and Suc-Gly-Pro-7-amido-4-methylcoumarin. DeuA and DeuB have similar digestion property against the protein substrates, but DeuB has a wider substrate specificity compared with DeuA
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-
?
additional information
?
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DeuB can not digest collagen. DeuA and DeuB have similar digestion property against the protein substrates, but DeuB has a wider substrate specificity compared with DeuA
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-
?
additional information
?
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DeuB can not digest collagen. DeuA and DeuB have similar digestion property against the protein substrates, but DeuB has a wider substrate specificity compared with DeuA
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-
?
additional information
?
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-
DeuB can not digest collagen. DeuA and DeuB have similar digestion property against the protein substrates, but DeuB has a wider substrate specificity compared with DeuA
-
-
?
additional information
?
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DeuA can not digest elastin and collagen. No hydrolysis of benzyloxycarbonyl-Val-Lys-Met-7-amido-4-methylcoumarin, benzyloxycarbonyl-Leu-Arg-7-amido-4-methylcoumarin, benzyloxycarbonyl-Val-Val-Arg-7-amido-4-methylcoumarin and Suc-Gly-Pro-7-amido-4-methylcoumarin. DeuA and DeuB have similar digestion property against the protein substrates, but DeuB has a wider substrate specificity compared with DeuA
-
-
?
additional information
?
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DeuA can not digest elastin and collagen. No hydrolysis of benzyloxycarbonyl-Val-Lys-Met-7-amido-4-methylcoumarin, benzyloxycarbonyl-Leu-Arg-7-amido-4-methylcoumarin, benzyloxycarbonyl-Val-Val-Arg-7-amido-4-methylcoumarin and Suc-Gly-Pro-7-amido-4-methylcoumarin. DeuA and DeuB have similar digestion property against the protein substrates, but DeuB has a wider substrate specificity compared with DeuA
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-
?
additional information
?
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DeuB can not digest collagen. DeuA and DeuB have similar digestion property against the protein substrates, but DeuB has a wider substrate specificity compared with DeuA
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-
?
additional information
?
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DeuB can not digest collagen. DeuA and DeuB have similar digestion property against the protein substrates, but DeuB has a wider substrate specificity compared with DeuA
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-
?
additional information
?
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not: benzyloxycarbonyl-Gly-Phe-NH2 and benzyloxycarbonyl-Gly-Leu-NH2
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-
?
additional information
?
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no cleavage of any disubstituted dipeptides
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-
?