Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Aggrecan core protein + H2O
?
-
-
-
-
?
chondroitin sulfate proteoglycan + H2O
?
-
-
-
-
?
collagen I + H2O
?
-
-
-
-
?
Collagen type I + H2O
?
-
-
-
-
?
Collagen type III + H2O
?
-
-
-
-
?
collagen type XI + H2O
?
-
-
-
-
?
dentin sialoprotein + H2O
?
the enzyme highly efficiently cleaves dentin sialoprotein into distinct fragments in vitro, and the deletion of Mmp9 causes improper processing of dentin sialoprotein in natural teeth
-
-
?
epidermal growth factor + H2O
?
-
MMP-9 induces TGF-beta1 production in the airway epithelium through the cleavage of epidermal growth factor, EGF, and membrane-bound EGF-like ligands and activating epidermal growth factor receptor
-
-
?
fibrillar collagen + H2O
?
islet amyloid polypeptide + H2O
?
pro-urokinase + H2O
active urokinase + prosequence of urokinase
transforming growth factor-beta + H2O
?
-
MMP9 mediates activation of latent transforming growth factor-beta
-
-
?
additional information
?
-
Collagen + H2O
?
-
MMP-9 inhibits collagen-induced platelet aggregation
-
-
?
Collagen + H2O
?
-
-
-
-
?
collagen type IV + H2O
?
-
-
-
-
?
collagen type IV + H2O
?
-
-
-
-
?
collagen type V + H2O
?
-
-
-
-
?
collagen type V + H2O
?
-
-
-
-
?
Elastin + H2O
?
-
-
-
-
?
Elastin + H2O
?
-
MMP-9 activity leads to elastin breakdown in an animal model of Kawasaki disease, a multisystem vasculitis leading to damage in the coronary circulationand aneurysm formation, overview
-
-
?
fibrillar collagen + H2O
?
-
degradation
-
-
?
fibrillar collagen + H2O
?
-
degradation, MMP-9 is involved in development of osteoarthritis, overview
-
-
?
Fibronectin + H2O
?
-
-
-
-
?
Fibronectin + H2O
?
-
-
-
-
?
Gelatin + H2O
?
-
-
-
-
?
Gelatin + H2O
?
-
-
-
-
?
Gelatin + H2O
?
Gallus gallus Hy-Line Brown
-
-
-
?
Gelatin + H2O
?
-
-
-
-
?
Gelatin + H2O
?
-
-
-
-
?
Gelatin + H2O
?
-
-
-
-
?
Gelatin + H2O
?
-
MMP-9 is involved in the degradation of the extracellular matrix, and is implicated in a variety of pathological conditions including cardiovascular and neoplastic diseases
-
-
?
Gelatin + H2O
?
-
-
-
-
?
Gelatin + H2O
?
-
-
-
-
?
Gelatin + H2O
?
-
-
-
-
?
Gelatin + H2O
?
-
-
-
-
?
Gelatin + H2O
?
-
-
-
-
?
islet amyloid polypeptide + H2O
?
enzyme MMP-9 degrades amyloidogenic humanislet amyloid polypeptide but not nonamyloidogenic mouse islet amyloid polypeptide
-
-
?
islet amyloid polypeptide + H2O
?
enzyme MMP-9 degrades amyloidogenic human islet amyloid polypeptide but not nonamyloidogenic mouse islet amyloid polypeptide
-
-
?
islet amyloid polypeptide + H2O
?
enzyme MMP-9 degrades amyloidogenic human islet amyloid polypeptide but not nonamyloidogenic mouse islet amyloid polypeptide
-
-
?
Laminin + H2O
?
-
degradation
-
-
?
Laminin + H2O
?
-
degradation
-
-
?
Laminin + H2O
?
-
-
-
-
?
Laminin + H2O
?
-
-
-
-
?
Laminin + H2O
?
-
-
-
-
?
pro-urokinase + H2O
active urokinase + prosequence of urokinase
-
-
-
-
?
pro-urokinase + H2O
active urokinase + prosequence of urokinase
-
-
-
-
?
additional information
?
-
-
active host MMP-9 is expressed in walls and fluids of hydatid cysts of parasite Echinococcus granulosus in the environment of granulomatous reaction, in vivo activation of MMP-9 suggests its involvement in inflammatory reaction and in the chemotaxis of inflammatory cells to the cyst. However, the parasite can deal efficiently with MMP-9, overview
-
-
?
additional information
?
-
-
may be responsible for the pathological degradation and/or normal turnover of vitronectin
-
-
?
additional information
?
-
-
possible role of the enzyme in the structural tissue remodeling of the developing embryo
-
-
?
additional information
?
-
-
plays a role in tumor cell invasion and in destruction of cartilage in arthritis
-
-
?
additional information
?
-
-
enzyme may play a role in the destruction of the extracellular matrix, perhaps acting in concert with the metalloproteases produced by activated endothelial cells
-
-
?
additional information
?
-
associated with degradation of the extracellular matrix in normal and pathological conditions
-
?
additional information
?
-
-
central role in the degradation of the extracellular matrix
-
?
additional information
?
-
-
leading role in the catabolism of the macromolecular components of the extracellular matrix in a variety of normal and pathological processes, involved in inflammation, tissue remodeling and cancer
-
?
additional information
?
-
-
cells resistant to protein kinase C potentiated, transkription factor p53 mediated apoptosis express a higher level of matrix metalloproteinases MMP-9 and MMP-10. Matrix metalloproteinases function confers protection from protein kinase C/p53 induced apoptosis and are implicated in tumor cell resistance
-
-
?
additional information
?
-
-
collagen binding domains of matrix metalloproteinases MMP-2 and MMP-9 bind the same or closely positioned sites on type I collagen
-
-
?
additional information
?
-
-
enzyme and leucocyte elastase are essential for granulocyte-mediated proteolysis resulting in dermal-epidermal separation in epidermolysis bullosa acquisita and bullous pemphigoid patients skin
-
-
?
additional information
?
-
-
activated MMP-9 initially induces conformational changes in platelet membranes, affecting membrane fluidity, and hydroxyl radical formation and inhibits the Na+/H+ pump, both leading to inhibition of platelet aggregation, the latter via reduced Ca2+ mobilization, overview. MMP-9 also inhibits arachidonic acid, ADP, and U46619 inducetion of platelet aggregation, overview
-
-
?
additional information
?
-
-
activation of MMP-9 may contribute to dentin matrix degradation, which occurs during caries progression and follows resin bonding. Inhibition of MMP-9 proteolytic activity may slow caries progression and increase the durability of resin-dentin bond, overview
-
-
?
additional information
?
-
-
gelatinase B expression is a prognostic factor in patients with stage II/III rectal carcinoma treated by postoperative adjuvant therapy, overview
-
-
?
additional information
?
-
-
MMP-9 activity is associated with poor prognosis in T3-T4 node-negative colorectal cancer, its expression is not correlated with MMP-2 and reversion-inducing cysteine-rich protein, RECK, expression in cancer cells, overview
-
-
?
additional information
?
-
-
MMP-9 expression is increased in cancers, inhibition of MMP-9 has a therapeutic benefit to cancer
-
-
?
additional information
?
-
-
MMP-9 is activated by monomeric hemin and by MMP-3 cleaving at Glu40-Met41 and Arg87-Phe88, and at Glu40-Met41 and Leu52-Leu53, respectively, no effect by hemoglobin, overview
-
-
?
additional information
?
-
-
MMP-9 is involved in development of endometriosis, MMP-9 levels are decreased by about 50% after operation of endometriosis, overview
-
-
?
additional information
?
-
-
MMP-9 is secreted by macrophages at wound sites and is involved in wound repair together with relaxin, molecular mechanism, overview. Transcription factor NF-kappaB is important in MMP gene regulation in macrophage cells, overview, relaxin-induced tissue remodeling through increasing MMP-9 expression is dependent on NF-kappaB activation
-
-
?
additional information
?
-
-
the enzyme is involved in breakdown of extracellular matrix components, and basement membrane disruption, stroma and blood vessel penetration, and metastasis. It participates in tumor growth and angiogensis, overview
-
-
?
additional information
?
-
the enzyme cleaves many substrates
-
-
?
additional information
?
-
-
acrolein subtypes A and C from cigarette smoke induces persistent mucin production via activation of matrix metalloproteinase 9 through induction of pro-MMP-9 cleavage and activation and EGFR/MAPK signaling also leading to MMP-9 activation, regulation, overview
-
-
?
additional information
?
-
-
gastric gelatinase B is rapidly increased in Helicobacter felis-infected mice and is involved in induction of gastritis
-
-
?
additional information
?
-
-
MMP-9 activity plays a central role in modulating the clinical course and severity of respiratory tularemia, Pro-Gly-Pro, a potent neutrophil chemotactic tripeptide, is released from extracellular matrix through the action of MMP-9, MMP-9 is involved in leukocyte recruitment, pulmonary infection with the Gram-negative intracellular bacterium Francisella tularensis, a category A biological threat agent, induces MMP-9 expression, MMP-9 is associated with higher bacterial burdens in pulmonary and extrapulmonary tissues, development of more extensive histopathology predominated by neutrophils, and increased morbidity and mortality compared to mice lacking MMP-9
-
-
?
additional information
?
-
-
MMP-9 inhibitor completely inhibits PAF-induced B16F10 metastasis
-
-
?
additional information
?
-
-
MMP-9 is essential for neutrophil infiltration during zymosan peritonitis
-
-
?
additional information
?
-
-
MMP-9 is involved in murine peritonitis by participating in cellular migration, molecular mechanism, overview
-
-
?
additional information
?
-
-
MMP-9 plays an important role in degradation of gastric extracellular matrix proteins, MMP-9 is reduced by melatonin produced during gastric ulcer development, overview
-
-
?
additional information
?
-
-
nitric oxide regulates matrix metalloproteinase-9 activity by guanylyl-cyclase-dependent and -independent pathways, Sper/NO shows biphasic regulation of MMP-9 inactivated macrophages, overview
-
-
?
additional information
?
-
-
MMP-9 is involved in murine peritonitis by participating in cellular migration, molecular mechanism, overview
-
-
?
additional information
?
-
-
MMP-9 plays an important role in degradation of gastric extracellular matrix proteins, MMP-9 is reduced by melatonin produced during gastric ulcer development, overview
-
-
?
additional information
?
-
-
gastric gelatinase B is rapidly increased in Helicobacter felis-infected mice and is involved in induction of gastritis
-
-
?
additional information
?
-
-
MMP-9 is essential for neutrophil infiltration during zymosan peritonitis
-
-
?
additional information
?
-
-
nitric oxide regulates matrix metalloproteinase-9 activity by guanylyl-cyclase-dependent and -independent pathways, Sper/NO shows biphasic regulation of MMP-9 inactivated macrophages, overview
-
-
?
additional information
?
-
-
MMP-9 activity plays a central role in modulating the clinical course and severity of respiratory tularemia, Pro-Gly-Pro, a potent neutrophil chemotactic tripeptide, is released from extracellular matrix through the action of MMP-9, MMP-9 is involved in leukocyte recruitment, pulmonary infection with the Gram-negative intracellular bacterium Francisella tularensis, a category A biological threat agent, induces MMP-9 expression, MMP-9 is associated with higher bacterial burdens in pulmonary and extrapulmonary tissues, development of more extensive histopathology predominated by neutrophils, and increased morbidity and mortality compared to mice lacking MMP-9
-
-
?
additional information
?
-
-
enzyme may be necessary for initiating or completing degradation of type I/type V copolymeric fibrils for growth and remodeling of extracellular collagen
-
-
?
additional information
?
-
-
independent of its proteolytic function, enzyme has a biphasic effect on smooth muscle cell-mediated collagen gel contraction
-
-
?
additional information
?
-
-
astrocyte-released MMP-9 is involved in interleukin-1beta induced neurotoxicity, probably via urokinase plasminogen activator, overview
-
-
?
additional information
?
-
-
inhibition of MMP-9 prevents neutrophilic inflammation in ventilator-induced lung injury, VILI, and pulmonary hemorrhage, overview
-
-
?
additional information
?
-
-
myogenic reactivity, inhibited in small renal arteries isolated from nonpregnant rats treated with recombinant human relaxin, is completely restored by incubation with MMP-9, MMP-9 rather than MMP-2 plays a central role in the vasodilatory effect of short-term relaxin administration, overview
-
-
?