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diagnostics
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in patients with clinical signs of meningitis, but without cerebrospinal fluid pleocytosis, enzyme and MMP-8, MMP-13 are highly sensitive markers for intrathecal inflammation
diagnostics
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circulating concentrations of MMP-9 may be a marker helping in the diagnosis and prognosis of cardiovascular and neoplastic diseases
diagnostics
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gelatinase B expression as a prognostic factor in patients with stage II/III rectal carcinoma treated by postoperative adjuvant therapy, overview
diagnostics
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MMP-9 expression is an independent and significant factor for prediction of a poor prognosis in colorectal cancer
diagnostics
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MMP-9 levels are useful in endometriosis diagnostics
diagnostics
matrix metalloproteinase-9 expression in glioma is an independent prognostic factor of patients, which might be a potential diagnostic and therapeutic target of astrocytic glioma
drug development
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MMP-9 is a target for therapeutic treatment
drug development
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MMP-9 is a therapeutic target in autoimmune diseases, vascular pathologies, and cancer
drug development
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MMP-9 is an attractive target for therapeutic intervention studies in mouse models
medicine
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MMP-9 is suggested as a regulator of the angiogenic switch in tumor development
medicine
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abundant expression of enzyme by synovial tissue mast cells in patients with rheumatoid arthritis but not in normal control
medicine
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cells resistant to protein kinase C potentiated, transcription factor p53 mediated apoptosis express a higher level of matrix metalloproteinases MMP-9 and MMP-10. Matrix metalloproteinases function confers protection from protein kinase C/p53 induced apoptosis and are implicated in tumor cell resistance
medicine
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endogenous urokinase plasminogen activator from cultured hepatic stellate cells significantly induces the active forms of enzyme and matrix metalloproteinase MMP-2 in cirrhotic tissue slices. Transfection of hepatic stellate cells with urokinase plasminogen activator gene results in overactivation of enzyme and matrix metalloproteinases MMP-3 and MMP-2
medicine
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enzyme and leucocyte elastase are essential for granulocyte-mediated proteolysis resulting in dermal-epidermal separation in epidermolysis bullosa acquisita and bullous pemphigoid patients skin. Selective inhibition of enzyme by single-chain variable fragment of a monoclonal antibody results in suppression of blistering
medicine
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enzyme is present in extracts from leaking bleb tissue of glaucoma patients, but not in bleb leak fluid or aqueous humor samples
medicine
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enzyme levels are significantly elevated in cerebrospinal fluid of patients with vascular dementia compared to those with Alzheimer disease and to control
medicine
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enzyme, as well as monocyte chemotactic protein-1 and stromal cell-derived factor-1 may have a pathogenic role in the recruitment of leukocytes into the eye in sympathetic ophthalmia
medicine
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expression of enzyme is significantly higher in malignant than in nonmalignant prostate tissues. Significant difference in enzymatic activity among normal prostate, benign prostate hyperplasia, localized and metastatic tissue, and serum
medicine
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in children with aseptic and bacterial meningitis, both enzyme and collagenase MMP-8 show increased levels in cerebrospinal fluid. In patients with clinical signs of meningitis, but without cerebrospinal fluid pleocytosis, enzyme and MMP-8, MMP-13 are highly sensitive markers for intrathecal inflammation
medicine
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incubation of lenses with enzyme leads immediately to cataract
medicine
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majority of urine samples from patients with bladder cancer show enzyme activity. Enzyme content is enhanced in the urine from patieints with high-grade and advanced-stage bladder tumors. Urinary values of biomarkers tissue polypeptide-specific antigen and protein 22 of nuclear matrix correlate with the increase in enzyme activity in high-grade and advanced-stage bladder tumors
medicine
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neutrophils of patients with rheumatoid arthritis release considerable amounts of enzyme. Enzyme acts on fragments of collagen type II obtained by cleavage with collagenases MMP-1, MMP-8, or MMP-13. Enzyme produces small remnant peptides with still intact immunodominant epitopes. Lysines in the main immunodominant epitope are modified by partial hydroxylation and partial glycosylation
medicine
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proenzyme and enzyme levels are significantly increased in patients with proliferative diabetic retinopathy. Additionally, levels of tissue inhibitor of metalloproteinases-1 are significantly increased and functionally inhibit activation of enzyme in vitreous samples. Enzyme levels in vitreous samples of patients with hemorrhage are significantly higher than those in proliferative diabetic retinopathy patients and strongly correlate with hemoglobin levels
medicine
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ratio of matrx metalloproteinases MMP-9/MMP-2 is enhanced in cancer patients copared with benign diseases and healthy individuals. No correlation between gelatinolytic activity and high tumoral marker values is found
medicine
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a positive correlation between MMP-9 values and gestational age is observed in normal pregnant women
medicine
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brain levels of matrix metalloproteinase-9 are a marker of neuroinflammation, MMP-9 appears to be upregulated in microvessels within ischemic brain, MMP-9 levels are markedly lower in CD47 knockout brains compared to wild type brains
medicine
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cervicovaginal MMP-9 correlates with cervical ripening before labor at term, however, cervicovaginal MMP-9 does not change with spontaneous labor or rupture of membranes at term and does not predict success of labor induction
medicine
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higher levels of MMP-9 mRNA expression in the apical periodontitis when compared to healthy periapical ligaments, suggest that MMP-9 can be directly involved in tissue remodeling/destruction during lesion development
medicine
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matrix metalloproteinase is an independent predictor of the reduced nitrate-mediated dilatation in the type 1 diabetes mellitus
medicine
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matrix metalloproteinase-9 is an independent prognostic marker in laryngeal and hypopharyngeal cancer
medicine
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MMP-9 expression positively correlates with prognosis of oral squamous cell carcinoma
medicine
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MMP-9 genotype polymorphisms are primary predictors for oral squamous cell carcinoma risk
medicine
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MMP-9 is a marker of endothelial activation and dysfunction
medicine
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MMP-9 is an inflammatory marker in the tears of patients with ocular surface disease, pro-MMP-9 levels are significantly elevated in blepharitis, in allergic eye disease, in dry eye, and in conjunctivochalasis in comparison to controls
medicine
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serum MMP-9 level is related to FEV1 decline
medicine
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the expression of the mRNA of MMP-9 is not significantly elevated with the progression of biliary-associated liver fibrosis
medicine
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the functional polymorphism C1562T in the promoter of matrix metalloproteinase-9 gene is associated with susceptibility to knee osteoarthritis in the Turkish population
medicine
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the reduction of MMP-9 activity may have a possible therapeutic effect for the management of brain injury after focal ischemia
medicine
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there is an association of the allele distribution at the TIMP-1 +372 T/C locus, the levels of TIMP-1, -2, and MMP-9 in noninflamed tissue, and smoking habit with diagnostic and/or surgical recurrence of Crohn's disease
medicine
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controlling MMP-9 expression has therapeutic potential in Parkinson's disease
medicine
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down-regulation of the expression and activity of MMP-9 is a treatment alternative for plaque stabilization by inhibiting the nuclear factor-kappaB activation
medicine
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higher circulating MMP-9 concentrations are associated with abdominal aortic aneurysm presence
medicine
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imbalance between total MMP-9 and TIMP-1 may contribute to the pathogenesis of lupus nephritis
medicine
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MMP-9 is a nontraditional cardiovascular risk factor
medicine
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MMP-9 is a potential target for cerebral ischemic treatment in human stroke therapy
medicine
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MMP-9 is a potential therapeutic target for gastric adenocarcinomas
medicine
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MMP-9 is a potentially useful biomarker for diagnosing, classifying, and monitoring dysfunctional tear syndrome
medicine
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MMP-9 is a promising target for a neuroprotective approach to preventing seizure-induced hippocampal damage
medicine
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MMP-9 overexpression is an early marker of breast carcinogenesis preceding tumor invasion
medicine
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MMP-9 plasma levels are predictive of cognitive performance following carotid endarterectomy
medicine
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pharmacological inhibition of MMP-9 activity ameliorates skeletal muscle pathogenesis and enhanced myofiber regeneration in mdx mice. MMP-9 represents as one of the most promising therapeutic targets for the prevention of disease progression in Duchenne muscular dystrophy
medicine
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pretreatment serum levels of MMP-9 are powerful prognostic markers in patients with oral squamous cell carcinoma, patients with MMP-9 serum levels higher than median have significantly shorter overall survival than those with levels lower than median
medicine
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the serum levels of MMP-9 significantly correlate with the occurrence and severity of acute graft-versus-host disease
medicine
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MMP-9 induces TGF-beta1 production in the airway epithelium through the cleavage of EGF and EGF-like ligands and activating EGFR, suggesting potential targets of therapeutic intervention in airway fibrotic disorders
medicine
matrix metalloproteinase-9 expression in glioma is an independent prognostic factor of patients, which might be a potential diagnostic and therapeutic target of astrocytic glioma
medicine
serum MMP9 levels are significantly associated with hyperlipidaemia