3.4.24.30: coccolysin
This is an abbreviated version!
For detailed information about coccolysin, go to the full flat file.
Reaction
Preferential cleavage: -/-Leu, -/-Phe, -/-Tyr, -/-Ala =
Synonyms
cell envelope protein, cell wall-anchored proteinase, CEP, EC 3.4.24.4, EM 19000, metalloendopeptidase II, microbial proteinase, PrtS, streptococcal gelatinase, Streptococcus thermophilus intracellular proteinase
ECTree
3.4.24.30 coccolysinAdvanced search results
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results (Inhibitors
Inhibitors on EC 3.4.24.30 - coccolysin
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INHIBITOR 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
IMAGE
3,4,5,6-Tetrachloro-1,2-benzoquinone
-
i.e. o-chloranil, 0.003 mM, most potent inactivator
High MW factor of rat inflammatory exudate
-
strong, MW: 720000-750000
-
phenylmethylsulfonyl fluoride
strongly inhibited, 100% inhibition
phosphoramidon
-
i.e. N-(alpha-L-rhamnopyranosyloxy-hydroxyphosphinyl)-L-Leu-L-Trp
EDTA
-
reversible by Co2+, Mn2+, Zn2+, Ca2+, Cu2+ or Mg2+ with decreasing order of efficiency, not by Cd2+, Ba2+, Ni2+ or Hg2+
additional information
-
no inhibition by DTNB, carbodiimide/glycine ethyl ester; no inhibition by iodoacetate; no inhibition by PMSF, phenylglyoxal; no inhibition by tosyl-Leu chloromethyl ketone, tosyl-Phe chloromethyl ketone, trasylol (i.e. bovine lung trypsin inhibitor)
-
additional information
-
no inhibition by 2,3-butanedinone; no inhibition by PMSF, phenylglyoxal
-
additional information
-
diisopropyl fluorophosphate; no inhibition by iodoacetate
-
additional information
no inhibition with bestatin or E64
-
