3.4.24.24: gelatinase A
This is an abbreviated version!
For detailed information about gelatinase A, go to the full flat file.
Word Map on EC 3.4.24.24
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3.4.24.24
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mmp-9
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metalloproteinases
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zymography
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metastasis
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timp-2
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endothelial
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angiogenesis
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artery
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fibrosis
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necrosis
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gelatinolytic
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invasiveness
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transwell
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basement
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tnf
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mt1-mmp
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plasminogen
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cardiac
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neutrophil
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aortic
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vessel
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integrins
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fibronectin
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upa
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melanoma
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laminin
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matrigel
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vimentin
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myocardial
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interstitial
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proteinases
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lymph
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ventricular
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e-cadherin
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nude
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angiogenic
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aneurysm
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mesenchymal
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stromelysins
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anti-metastatic
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fak
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medicine
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elastin
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cox-2
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synthesis
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urokinase
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collagenases
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urokinase-type
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collagenolytic
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tgf-beta1
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diagnostics
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lipocalin
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boyden
- 3.4.24.24
- mmp-9
- metalloproteinases
-
zymography
- metastasis
- timp-2
- endothelial
- angiogenesis
- artery
- fibrosis
- necrosis
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gelatinolytic
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invasiveness
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transwell
-
basement
- tnf
- mt1-mmp
- plasminogen
- cardiac
- neutrophil
- aortic
- vessel
- integrins
- fibronectin
- upa
- melanoma
- laminin
- matrigel
- vimentin
- myocardial
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interstitial
- proteinases
- lymph
- ventricular
- e-cadherin
-
nude
-
angiogenic
- aneurysm
- mesenchymal
- stromelysins
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anti-metastatic
- fak
- medicine
- elastin
- cox-2
- synthesis
- urokinase
- collagenases
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urokinase-type
-
collagenolytic
- tgf-beta1
- diagnostics
-
lipocalin
-
boyden
Reaction
Cleavage of gelatin type I and collagen types IV, V, VII, X. Cleaves the collagen-like sequence Pro-Gln-Gly-/-Ile-Ala-Gly-Gln =
Synonyms
72 kDa Gelatinase, 72 kDa Gelatinase type A, 72 kDa type IV collagenase, 72-kDa Gelatinase, Collagenase IV, Collagenase type IV, GelA, gelatinase, gelatinase A, human gelatinase A, human matrix metalloproteinase 2, human matrix metalloproteinase-2, LvMMP-2, matrix metallopeptidase 2, matrix metalloprotease 2, Matrix metalloproteinase 2, matrix metalloproteinase-2, matrix metalloprotenase-2, metalloproteinase-2, metrix metalloproteinase-2, MMP 2, MMP-2, MMP2, progelatinase, Type IV collagen metalloproteinase, Type IV collagenase, Type IV collagenase/gelatinase
ECTree
3.4.24.24 gelatinase AAdvanced search results
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Reference on EC 3.4.24.24 - gelatinase A
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Netzel-Arnett, S.; Sang, Q.X.; Moore, W.G.I.; Navre, M.; Birkedal-Hansen, H.; van Wart, H.E.
Comparative sequence specificities of human 72- and 92-kDa gelatinases (type IV collagenases) and PUMP (matrilysin)
Biochemistry
32
6427-6432
1993
Homo sapiens
Okada, Y.; Morodomi, T.; Enghild, J.J.; Suzuki, K.; Yasui, A.; Nakanishi, I.; Salvesen, G.; Nagase, H.
Matrix metalloproteinase 2 from human rheumatoid synovial fibroblasts. Purification and activation of the precursor and enzymic properties
Eur. J. Biochem.
194
721-730
1990
Homo sapiens
Murphy, G.; McAlpine, C.G.; Poll, C.T.; Reynolds, J.J.
Purification and characterization of a bone metalloproteinase that degrades gelatin and types IV and V collagen
Biochim. Biophys. Acta
831
49-58
1985
Oryctolagus cuniculus
Collier, I.E.; Wilhelm, S.M.; Eisen, A.Z.; Marmer, B.L.; Grant, G.A.; Seltzer, J.L.; Kronberger, A.; He, C.; Bauer, E.A.; Goldberg, G.I.
H-ras oncogene-transformed human bronchial epithelial cells (TBE-1) secrete a single metalloprotease capable of degrading basement membrane collagen
J. Biol. Chem.
263
6579-6587
1988
Homo sapiens
Nguyen, Q.; Murphy, G.; Hughes, C.E.; Mort, J.S.; Roughley, P.J.
Matrix metalloproteinases cleave at two distinct sites on human cartilage link protein
Biochem. J.
295
595-598
1993
Homo sapiens
Ochieng, J.; Fridman, R.; Nangia-Makker, P.; Kleiner, D.E.; Liotta, L.A.; Stetler-Stevenson, W.G.; Raz, A.
Galectin-3 is a novel substrate for human matrix metalloproteinases-2 and -9
Biochemistry
33
14109-14114
1994
Homo sapiens
Allan, J.A.; Docherty, A.J.P.; Barker, P.J.; Huskisson, N.S.; Reynolds, J.J.; Murphy, G.
Binding of gelatinases A and B to type-I collagen and other matrix components
Biochem. J.
309
299-306
1995
Homo sapiens
Imai, K.; Shikata, H.; Okada, Y.
Degradation of vitronectin by matrix metalloproteinases-1, -2, -3, -7 and -9
FEBS Lett.
369
249-251
1995
Homo sapiens
Aimes, R.T.; Quingley, J.P.
Matrix metalloproteinase-2 is an interstitial collagenase. Inhibitor-free enzyme catalyzes the cleavage of collagen fibrils and soluble native type I collagen generating the specific 3/4- and 1/4-length fragments
J. Biol. Chem.
270
5872-5876
1995
Gallus gallus
Fridman, R.; Bird, R.E.; Hoyhta, M.; Oelkuct, M.; Komarek, D.; Liang, C.M.; Berman, M.L.; Liotta, L.A.; Stetler-Stevenson, W.G.; Fuerst, T.R.
Expression of human recombinant 72 kDa gelatinase and tissue inhibitor of metalloproteinase-2 (TIMP-2): characterization of complex and free enzyme
Biochem. J.
289
411-416
1993
Homo sapiens
Willenbrock, F.; Crabbe, T.; Slocombe, P.M.; Sutton, C.W.; Docherty, A.J.P.; Cockett, M.I.; O'Shea, M.; Brocklehurst, K.; Phillips, I.R.; Murphy, G.
The activity of the tissue inhibitors of metalloproteinases is regulated by C-terminal domain interactions: a kinetic analysis of the inhibition of gelatinase A
Biochemistry
32
4330-4337
1993
Homo sapiens
Miyazaki, K.; Funahashi, K.; Numata, Y.; Koshikawa, N.; Akaogi, K.; Kikkawa, Y.; Yasumitsu, H.; Umeda, M.
Purification and characterization of a two-chain form of tissue inhibitor of metalloproteinases (TIMP) type 2 and a low molecular weight TIMP-like protein
J. Biol. Chem.
268
14387-14393
1993
Homo sapiens
Banyai, L.; Tordai, H.; Patthy, L.
The gelatin-binding site of human 72 kDa type IV collagenase (gelatinase A)
Biochem. J.
298
403-407
1994
Homo sapiens
Kolkenbrock, H.; Hecker-Kia, A.; Orgel, D.; Ruppitsch, W.; Ulbrich, N.
Activity of ternary gelatinase A-TIMP-2-matrix metallo-proteinase complexes
Biol. Chem. Hoppe-Seyler
375
589-595
1994
Oryctolagus cuniculus
Ye, Q.Z.; Johnson, L.L.; Yu, A.E.; Hupe, D.
Reconstructed 19 kDa catalytic domain of gelatinase A is an active proteinase
Biochemistry
34
4702-4708
1995
Homo sapiens
LePage, R.N.; Fosang, A.J.; Fuller, S.J.; Murphy, G.; Evin, G.; Beyreuther, K.; Masters, C.L.; Small, D.H.
Gelatinase A possesses a beta-secretase-like activity in cleaving the amyloid protein precursor of Alzheimers disease
FEBS Lett.
377
267-270
1995
Homo sapiens
Gohlke, U.; Gomis-Ruth, F.X.; Crabbe, T.; Murphy, G.; Docherty, A.J.P.; Bode, W.
The C-terminal (haemopexin-like) domain structure of human gelatinase A (MMP2): structural implications for its function
FEBS Lett.
378
126-130
1996
Homo sapiens
Libson, A.M.; Gittis, A.G.; Collier, I.E.; Marmer, B.L.; Goldberg, G.I.; Lattman, E.E.
Crystal structure of the haemopexin-like C-terminal domain of gelatinase A [letter]
Nat. Struct. Biol.
2
938-942
1995
Homo sapiens
Murphy, G.; Crabbe, T.
Gelatinases A and B
Methods Enzymol.
248
470-484
1995
Homo sapiens
Fridman, R.; Toth, M.; Pena, D.; Mobashery, S.
Activation of progelatinase B (MMP-9) by gelatinase A (MMP-2)
Cancer Res.
55
2548-2555
1995
Homo sapiens
Lee, H.J.; Chung, M.C.; Lee, C.H.; Chun, H.K.; Kho, Y.H.
Purification of progelatinase A (matrix metalloproteinase 2) and a tissue inhibitor of metalloproteinase-2 (TIMP-2) from T98G human glioblastoma cells
J. Biochem. Mol. Biol.
28
33-39
1995
Homo sapiens
-
Ochieng, J.; Warfield, P.; Green, B.
Interactions of gelatinases with soluble and immobilized fetuin and asialofetuin
Arch. Biochem. Biophys.
322
250-255
1995
Homo sapiens
Hutton, M.; Willenbrock, F.; Brocklehurst, K.; Murphy, G.
Kinetic analysis of the mechanism of interaction of full-length TIMP-2 and gelatinase A: evidence for the existence of a low-affinity intermediate
Biochemistry
37
10094-10098
1998
Homo sapiens
Feng, Y.; Likos, J.J.; Zhu, L.; Woodward, H.; Munie, G.; McDonald, J.J.; Stevens, A.M.; Howard, C.P.; De Crescenzo, G.A.; Welsch, D.; Shieh, H.S.; Stallings, W.C.
Solution structure and backbone dynamics of the catalytic domain of matrix metalloproteinase-2 complexed with a hydroxamic acid inhibitor
Biochim. Biophys. Acta
1598
10-23
2002
Homo sapiens
Gehrmann, M.; Briknarova, K.; Banyai, L.; Patthy, L.; Llinas, M.
The col-1 module of human matrix metalloproteinase-2 (MMP-2): structural/functional relatedness between gelatin-binding fibronectin type II modules and lysine-binding kringle domains
Biol. Chem.
383
137-148
2002
Homo sapiens
Collier, I.E.; Saffarian, S.; Marmer, B.L.; Elson, E.L.; Goldberg, G.
Substrate recognition by gelatinase A: the C-terminal domain facilitates surface diffusion
Biophys. J.
81
2370-2377
2001
Homo sapiens
Tordai, H.; Patthy, L.
The gelatin-binding site of the second type-II domain of gelatinase A/MMP-2
Eur. J. Biochem.
259
513-518
1999
Homo sapiens
Lee, S.J.; Jang, J.W.; Kim, Y.M.; Lee, H.I.; Jeon, J.Y.; Kwon, Y.G.; Lee, S.T.
Endostatin binds to the catalytic domain of matrix metalloproteinase-2
FEBS Lett.
519
147-152
2002
Homo sapiens
Bigg, H.F.; Shi, Y.E.; Liu, Y.E.; Steffensen, B.; Overall, C.M.
Specific, high affinity binding of tissue inhibitor of metalloproteinases-4 (TIMP-4) to the COOH-terminal hemopexin-like domain of human gelatinase A. TIMP-4 binds progelatinase A and the COOH-terminal domain in a similar manner to TIMP-2
J. Biol. Chem.
272
15496-15500
1997
Homo sapiens
Olson, M.W.; Gervasi, D.C.; Mobashery, S.; Fridman, R.
Kinetic analysis of the binding of human matrix metalloproteinase-2 and -9 to tissue inhibitor of metalloproteinase (TIMP)-1 and TIMP-2
J. Biol. Chem.
272
29975-29983
1997
Homo sapiens
Wallon, U.M.; Overall, C.M.
The hemopexin-like domain (C domain) of human gelatinase A (matrix metalloproteinase-2) requires Ca2+ for fibronectin and heparin binding. Binding properties of recombinant gelatinase A C domain to extracellular matrix and basement membrane components
J. Biol. Chem.
272
7473-7481
1997
Homo sapiens
Kleifeld, O.; Kotra, L.P.; Gervasi, D.C.; Brown, S.; Bernardo, M.M.; Fridman, R.; Mobashery, S.; Sagi, I.
X-ray absorption studies of human matrix metalloproteinase-2 (MMP-2) bound to a highly selective mechanism-based inhibitor. comparison with the latent and active forms of the enzyme
J. Biol. Chem.
276
17125-17131
2001
Homo sapiens (P08253), Homo sapiens
Chen, E.I.; Kridel, S.J.; Howard, E.W.; Li, W.; Godzik, A.; Smith, J.W.
A unique substrate recognition profile for matrix metalloproteinase-2
J. Biol. Chem.
277
4485-4491
2002
Homo sapiens
Higashi, S.; Miyazaki, K.
Identification of a region of beta-amyloid precursor protein essential for its gelatinase A inhibitory activity
J. Biol. Chem.
278
14020-14028
2003
Homo sapiens
Chen, E.I.; Li, W.; Godzik, A.; Howard, E.W.; Smith, J.W.
A residue in the S2 subsite controls substrate selectivity of matrix metalloproteinase-2 and matrix metalloproteinase-9
J. Biol. Chem.
278
17158-17163
2003
Homo sapiens (P08253)
Lauer-Fields, J.L.; Sritharan, T.; Stack, M.S.; Nagase, H.; Fields, G.B.
Selective hydrolysis of triple-helical substrates by matrix metalloproteinase-2 and -9
J. Biol. Chem.
278
18140-18145
2003
Homo sapiens
Rosenblum, G.; Meroueh, S.O.; Kleifeld, O.; Brown, S.; Singson, S.P.; Fridman, R.; Mobashery, S.; Sagi, I.
Structural basis for potent slow binding inhibition of human matrix metalloproteinase-2 (MMP-2)
J. Biol. Chem.
278
27009-27015
2003
Homo sapiens (P08253), Homo sapiens
Tamura, Y.; Watanabe, F.; Nakatani, T.; Yasui, K.; Fuji, M.; Komurasaki, T.; Tsuzuki, H.; Maekawa, R.; Yoshioka, T.; Kawada, K.; Sugita, K.; Ohtani, M.
Highly selective and orally active inhibitors of type IV collagenase (MMP-9 and MMP-2): N-sulfonylamino acid derivatives
J. Med. Chem.
41
640-649
1998
Homo sapiens
Cheng, D.; Shen, Q.; Nan, F.; Qian, Z.; Ye, Q.Z.
Purification and characterization of catalytic domains of gelatinase A with or without fibronectin insert for high-throughput inhibitor screening
Protein Expr. Purif.
27
63-74
2003
Homo sapiens
Briknarova, K.; Grishaev, A.; Banyai, L.; Tordai, H.; Patthy, L.; Llinas, M.
The second type II module from human matrix metalloproteinase 2: structure, function and dynamics
Structure
7
1235-1245
1999
Homo sapiens
Wang, M.; Zhao, D.; Spinetti, G.; Zhang, J.; Jiang, L.Q.; Pintus, G.; Monticone, R.; Lakatta, E.G.
Matrix metalloproteinase 2 activation of transforming growth factor-beta1 (TGF-beta1) and TGF-beta1-type II receptor signaling within the aged arterial wall
Arterioscler. Thromb. Vasc. Biol.
26
1503-1509
2006
Rattus norvegicus
Xu, X.; Chen, Z.; Wang, Y.; Yamada, Y.; Steffensen, B.
Functional basis for the overlap in ligand interactions and substrate specificities of matrix metalloproteinases-9 and -2
Biochem. J.
392
127-134
2005
Homo sapiens
Rossello, A.; Nuti, E.; Orlandini, E.; Carelli, P.; Rapposelli, S.; Macchia, M.; Minutolo, F.; Carbonaro, L.; Albini, A.; Benelli, R.; Cercignani, G.; Murphy, G.; Balsamo, A.
New N-arylsulfonyl-N-alkoxyaminoacetohydroxamic acids as selective inhibitors of gelatinase A (MMP-2)
Bioorg. Med. Chem.
12
2441-2450
2004
Homo sapiens
Banerji, A.; Chakrabarti, J.; Mitra, A.; Chatterjee, A.
Effect of curcumin on gelatinase A (MMP-2) activity in B16F10 melanoma cells
Cancer Lett.
211
235-242
2004
Mus musculus
Kozaci, L.D.; Guner, A.; Oktay, G.; Guner, G.
Alterations in biochemical components of extracellular matrix in intervertebral disc herniation: role of MMP-2 and TIMP-2 in type II collagen loss
Cell Biochem. Funct.
24
431-436
2006
Homo sapiens
Hasebe, T.; Hartman, R.; Matsuda, H.; Shi, Y.B.
Spatial and temporal expression profiles suggest the involvement of gelatinase A and membrane type 1 matrix metalloproteinase in amphibian metamorphosis
Cell Tissue Res.
324
105-116
2006
Xenopus laevis
Calabro, A.; Grappone, C.; Pellegrini, G.; Evangelista, S.; Tramontana, M.; Schuppan, D.; Herbst, H.; Milani, S.
Spatial and temporal pattern of expression of interstitial collagenase, stromelysin/transin, gelatinase A, and TIMP-1 during experimental gastric ulcer healing
Digestion
70
127-138
2004
Rattus norvegicus
Di Carlo, A.; Terracciano, D.; Mariano, A.; Macchia, V.
Matrix metalloproteinase-2 and matrix metalloproteinase-9 type IV collagenases in serum of patients with pleural effusions
Int. J. Oncol.
26
1363-1368
2005
Homo sapiens
Khorramizadeh, M.R.; Aalizadeh, N.; Pezeshki, M.; Ghahary, A.; Zeraati, H.; Berahmeh, A.; Safa, O.; Saadat, F.
Determination of gelatinase A using a modified indirect hemagglutination assay in human prostate cancer screening and assessment of its correlation with prostate-specific antigen parameters
Int. J. Urol.
12
637-643
2005
Homo sapiens
Karagiannis, E.D.; Popel, A.S.
A theoretical model of type I collagen proteolysis by matrix metalloproteinase (MMP) 2 and membrane type 1 MMP in the presence of tissue inhibitor of metalloproteinase 2
J. Biol. Chem.
279
39105-39114
2004
synthetic construct
Tam, E.M.; Moore, T.R.; Butler, G.S.; Overall, C.M.
Characterization of the distinct collagen binding, helicase and cleavage mechanisms of matrix metalloproteinase 2 and 14 (gelatinase A and MT1-MMP): the differential roles of the MMP hemopexin c domains and the MMP-2 fibronectin type II modules in collage
J. Biol. Chem.
279
43336-43344
2004
Homo sapiens
Gehrmann, M.L.; Douglas, J.T.; Banyai, L.; Tordai, H.; Patthy, L.; Llinas, M.
Modular autonomy, ligand specificity, and functional cooperativity of the three in-tandem fibronectin type II repeats from human matrix metalloproteinase 2
J. Biol. Chem.
279
46921-46929
2004
Homo sapiens
Kato, K.; Hara, A.; Kuno, T.; Kitaori, N.; Huilan, Z.; Mori, H.; Toida, M.; Shibata, T.
Matrix metalloproteinases 2 and 9 in oral squamous cell carcinomas: manifestation and localization of their activity
J. Cancer Res. Clin. Oncol.
131
340-346
2005
Homo sapiens
Gonzalez-Cuevas, J.; Bueno-Topete, M.; Armendariz-Borunda, J.
Urokinase plasminogen activator stimulates function of active forms of stromelysin and gelatinases (MMP-2 and MMP-9) in cirrhotic tissue
J. Gastroenterol. Hepatol.
21
1544-1554
2006
Rattus norvegicus
Ikejiri, M.; Bernardo, M.M.; Meroueh, S.O.; Brown, S.; Chang, M.; Fridman, R.; Mobashery, S.
Design, synthesis, and evaluation of a mechanism-based inhibitor for gelatinase A
J. Org. Chem.
70
5709-5712
2005
Homo sapiens
Xu, X.; Wang, Y.; Lauer-Fields, J.L.; Fields, G.B.; Steffensen, B.
Contributions of the MMP-2 collagen binding domain to gelatin cleavage. Substrate binding via the collagen binding domain is required for hydrolysis of gelatin but not short peptides
Matrix Biol.
23
171-181
2004
Homo sapiens
Das, S.; Mandal, M.; Mandal, A.; Chakraborti, T.; Chakraborti, S.
Identification, purification and characterization of matrix metalloproteinase-2 in bovine pulmonary artery smooth muscle plasma membrane
Mol. Cell. Biochem.
258
73-89
2004
Bos taurus
Di Carlo, A.; Terracciano, D.; Mariano, A.; Macchia, V.
Urinary gelatinase activities (matrix metalloproteinases 2 and 9) in human bladder tumors
Oncol. Rep.
15
1321-1326
2006
Homo sapiens
Mountain, D.J.; Singh, M.; Menon, B.; Singh, K.
Interleukin-1beta increases expression and activity of matrix metalloproteinase-2 in cardiac microvascular endothelial cells: role of PKCalpha/beta1 and MAPKs
Am. J. Physiol. Cell Physiol.
292
C867-C875
2007
Rattus norvegicus
Monaco, S.; Gioia, M.; Rodriguez, J.; Fasciglione, G.F.; Di Pierro, D.; Lupidi, G.; Krippahl, L.; Marini, S.; Coletta, M.
Modulation of the proteolytic activity of matrix metalloproteinase-2 (gelatinase A) on fibrinogen
Biochem. J.
402
503-513
2007
Homo sapiens
Xu, X.; Chen, Z.; Wang, Y.; Bonewald, L.; Steffensen, B.
Inhibition of MMP-2 gelatinolysis by targeting exodomain-substrate interactions
Biochem. J.
406
147-155
2007
Homo sapiens
Moroy, G.; Denhez, C.; El Mourabit, H.; Toribio, A.; Dassonville, A.; Decarme, M.; Renault, J.H.; Mirand, C.; Bellon, G.; Sapi, J.; Alix, A.J.; Hornebeck, W.; Bourguet, E.
Simultaneous presence of unsaturation and long alkyl chain at P1 of Ilomastat confers selectivity for gelatinase A (MMP-2) over gelatinase B (MMP-9) inhibition as shown by molecular modelling studies
Bioorg. Med. Chem.
15
4753-4766
2007
Homo sapiens
Falcinelli, E.; Giannini, S.; Boschetti, E.; Gresele, P.
Platelets release active matrix metalloproteinase-2 in vivo in humans at a site of vascular injury: lack of inhibition by aspirin
Br. J. Haematol.
138
221-230
2007
Homo sapiens
Zhao, J.X.; Yang, L.P.; Wang, Y.F.; Qin, L.P.; Liu, D.Q.; Bai, C.X.; Nan, X.; Shi, S.S.; Pei, X.J.
Gelatinolytic activity of matrix metalloproteinase-2 and matrix metalloproteinase-9 in rat brain after implantation of 9L rat glioma cells
Eur. J. Neurol.
14
510-516
2007
Rattus norvegicus
Emara, M.; Cheung, P.Y.
Inhibition of sulfur compounds and antioxidants on MMP-2 and -9 at the activity level found during neonatal hypoxia-reoxygenation
Eur. J. Pharmacol.
544
168-173
2006
Homo sapiens, Sus scrofa
Hwang, E.S.; Lee, H.J.
Allyl isothiocyanate and its N-acetylcysteine conjugate suppress metastasis via inhibition of invasion, migration, and matrix metalloproteinase-2/-9 activities in SK-Hep 1 human hepatoma cells
Exp. Biol. Med. (Maywood)
231
421-430
2006
Homo sapiens
Sariahmetoglu, M.; Crawford, B.D.; Leon, H.; Sawicka, J.; Li, L.; Ballermann, B.J.; Holmes, C.; Berthiaume, L.G.; Holt, A.; Sawicki, G.; Schulz, R.
Regulation of matrix metalloproteinase-2 (MMP-2) activity by phosphorylation
FASEB J.
21
2486-2495
2007
Homo sapiens (P08253)
Kim, M.M.; Kim, S.K.
Chitooligosaccharides inhibit activation and expression of matrix metalloproteinase-2 in human dermal fibroblasts
FEBS Lett.
580
2661-2666
2006
Homo sapiens
Bogusiewicz, M.; Stryjecka-Zimmer, M.; Postawski, K.; Jakimiuk, A.J.; Rechberger, T.
Activity of matrix metalloproteinase-2 and -9 and contents of their tissue inhibitors in uterine leiomyoma and corresponding myometrium
Gynecol. Endocrinol.
23
541-546
2007
Homo sapiens
Strek, M.; Gorlach, S.; Podsedek, A.; Sosnowska, D.; Koziolkiewicz, M.; Hrabec, Z.; Hrabec, E.
Procyanidin oligomers from Japanese quince (Chaenomeles japonica) fruit inhibit activity of MMP-2 and MMP-9 metalloproteinases
J. Agric. Food Chem.
55
6447-6452
2007
Homo sapiens
Higashi, S.; Miyazaki, K.
Identification of amino acid residues of the matrix metalloproteinase-2 essential for its selective inhibition by beta-amyloid precursor protein-derived inhibitor
J. Biol. Chem.
283
10068-10078
2008
Homo sapiens
Jin, E.J.; Park, K.S.; Bang, O.S.; Kang, S.S.
Akt signaling regulates actin organization via modulation of MMP-2 activity during chondrogenesis of chick wing limb bud mesenchymal cells
J. Cell. Biochem.
102
252-261
2007
Gallus gallus
Mazzoni, A.; Mannello, F.; Tay, F.R.; Tonti, G.A.; Papa, S.; Mazzotti, G.; Di Lenarda, R.; Pashley, D.H.; Breschi, L.
Zymographic analysis and characterization of MMP-2 and -9 forms in human sound dentin
J. Dent. Res.
86
436-440
2007
Homo sapiens
Gao, L.; Kang, L.; Chen, Q.; Chen, C.; Xu, B.; Jiang, S.
Advanced glycation end products inhibit production and activity of matrix metalloproteinase-2 in human umbilical vein endothelial cells
J. Int. Med. Res.
35
709-715
2007
Homo sapiens
Rutges, J.; Kummer, J.; Oner, F.; Verbout, A.; Castelein, R.; Roestenburg, H.; Dhert, W.; Creemers, L.
Increased MMP-2 activity during intervertebral disc degeneration is correlated to MMP-14 levels
J. Pathol.
214
523-530
2008
Homo sapiens
Robinet, A.; Emonard, H.; Banyai, L.; Laronze, J.Y.; Patthy, L.; Hornebeck, W.; Bellon, G.
Collagen-binding domains of gelatinase A and thrombospondin-derived peptides impede endocytic clearance of active gelatinase A and promote HT1080 fibrosarcoma cell invasion
Life Sci.
82
376-382
2008
Homo sapiens
Wu, M.; Massaeli, H.; Durston, M.; Mesaeli, N.
Differential expression and activity of matrix metalloproteinase-2 and -9 in the calreticulin deficient cells
Matrix Biol.
26
463-472
2007
Mus musculus
Nakaichi, M.; Yunuki, T.; Okuda, M.; Une, S.; Taura, Y.
Activity of matrix metalloproteinase-2 (MMP-2) in canine oronasal tumors
Res. Vet. Sci.
82
271-279
2007
Canis lupus familiaris
Whitlock, G.A.; Dack. K.N.; Dickinson, R.P.; Lewis M.L
A novel series of highly selective inhibitors of MMP-3
Bioorg. Med. Chem. Lett.
17
6750-6753
2007
Homo sapiens
Tao, P.; Fisher, J.F.; Shi, Q.; Vreven, T.; Mobashery, S.; Schlegel, H.B.
Matrix metalloproteinase 2 inhibition: combined quantum mechanics and molecular mechanics studies of the inhibition mechanism of (4-phenoxyphenylsulfonyl)methylthiirane and its oxirane analogue
Biochemistry
48
9839-9847
2009
Homo sapiens
Lisboa, R.A.; Lisboa, F.A.; de Castro Santos, G.; Andrade, M.V.; Cunha-Melo, J.R.
Matrix metalloproteinase 2 activity decreases in human periodontal ligament fibroblast cultures submitted to simulated orthodontic force
In Vitro Cell. Dev. Biol. Anim.
45
614-621
2009
Homo sapiens
Sato, Y.; Kishi, J.; Suzuki, K.; Nakamura, H.; Hayakawa, T.
Sonic extracts from a bacterium related to periapical disease activate gelatinase A and inactivate tissue inhibitor of metalloproteinases TIMP-1 and TIMP-2
Int. Endod. J.
42
1104-1111
2009
Homo sapiens
Momi, S.; Falcinelli, E.; Giannini, S.; Ruggeri, L.; Cecchetti, L.; Corazzi, T.; Libert, C.; Gresele, P.
Loss of matrix metalloproteinase 2 in platelets reduces arterial thrombosis in vivo
J. Exp. Med.
206
2365-2379
2009
Homo sapiens
Marquez-Aguirre, A.; Sandoval-Rodriguez, A.; Gonzalez-Cuevas, J.; Bueno-Topete, M.; Navarro-Partida, J.; Arellano-Olivera, I.; Lucano-Landeros, S.; Armendariz-Borunda, J.
Adenoviral delivery of dominant-negative transforming growth factor beta type II receptor up-regulates transcriptional repressor SKI-like oncogene, decreases matrix metalloproteinase 2 in hepatic stellate cell and prevents liver fibrosis in rats
J. Gene Med.
11
207-219
2009
Homo sapiens
Akers, W.J.; Xu, B.; Lee, H.; Sudlow, G.; Fields, G.B.; Achilefu, S.; Edwards, W.B.
Detection of MMP-2 and MMP-9 activity in vivo with a triple-helical peptide optical probe
Bioconjug. Chem.
23
656-663
2012
Homo sapiens
Santos, F.C.; Rochel-Maia, S.S.; Fochi, R.A.; Justulin, L.A.; Santos, S.A.; Vilamaior, P.S.; Felisbino, S.L.; Goes, R.M.; Taboga, S.R.
MMP-2 and MMP-9 localization and activity in the female prostate during estrous cycle
Gen. Comp. Endocrinol.
173
419-427
2011
Meriones unguiculatus
Koo, B.H.; Han, J.H.; Yeom, Y.I.; Kim, D.S.
Thrombin-dependent MMP-2 activity is regulated by heparan sulfate
J. Biol. Chem.
285
41270-41279
2010
Homo sapiens
Gomes, J.R.; Omar, N.F.; dos Santos Neves, J.; Narvaes, E.A.; Novaes, P.D.
Immunolocalization and activity of the MMP-9 and MMP-2 in odontogenic region of the rat incisor tooth after post shortening procedure
J. Mol. Histol.
42
153-159
2011
Rattus norvegicus, Rattus norvegicus Wistar
Zhang, R.; Pan, X.; Huang, Z.; Weber, G.F.; Zhang, G.
Osteopontin enhances the expression and activity of MMP-2 via the SDF-1/CXCR4 axis in hepatocellular carcinoma cell lines
PLoS ONE
6
e23831
2011
Homo sapiens
Diaz, N.; Suarez, D.; Suarez, E.
Kinetic and binding effects in peptide substrate selectivity of matrix metalloproteinase-2: molecular dynamics and QM/MM calculations
Proteins
78
1-11
2010
Homo sapiens
Kawagoe, M.; Tsuruga, E.; Oka, K.; Sawa, Y.; Ishikawa, H.
Matrix metalloproteinase-2 degrades fibrillin-1 and fibrillin-2 of oxytalan fibers in the human eye and periodontal ligaments in vitro
Acta Histochem. Cytochem.
46
153-159
2013
Homo sapiens (P08253), Homo sapiens
Bauters, D.; Scroyen, I.; Van Hul, M.; Lijnen, H.
Gelatinase A (MMP-2) promotes murine adipogenesis
Biochim. Biophys. Acta
1850
1449-1456
2015
Mus musculus (P33434), Mus musculus, Mus musculus BALB/c (P33434)
Musumeci, G.; Magro, G.; Cardile, V.; Coco, M.; Marzagalli, R.; Castrogiovanni, P.; Imbesi, R.; Graziano, A.; Barone, F.; Di Rosa, M.; Castorina, S.; Castorina, A.
Characterization of matrix metalloproteinase-2 and -9, ADAM-10 and N-cadherin expression in human glioblastoma multiforme
Cell Tissue Res.
362
45-60
2015
Homo sapiens (P08253), Homo sapiens
Koo, B.; Kim, Y.; Han, J.; Kim, D.
Dimerization of matrix metalloproteinase-2 (MMP-2): functional implication in MMP-2 activation
J. Biol. Chem.
287
22643-22653
2012
Homo sapiens (P08253)
Higashi, S.; Hirose, T.; Takeuchi, T.; Miyazaki, K.
Molecular design of a highly selective and strong protein inhibitor against matrix metalloproteinase-2 (MMP-2)
J. Biol. Chem.
288
9066-9076
2013
Homo sapiens (P08253)
Goncalves, A.; Meschiari, C.; Stetler-Stevenson, W.; Nonato, M.; Alves, C.; Espreafico, E.; Gerlach, R.
Expression of soluble and functional full-length human matrix metalloproteinase-2 in Escherichia coli
J. Biotechnol.
157
20-24
2012
Homo sapiens (P08253), Homo sapiens
Wang, C.; Zhan, C.; Cai, Q.; Du, C.; Liu, G.; Su, W.; Cao, M.
Expression and characterization of common carp (Cyprinus carpio) matrix metalloproteinase-2 and its activity against type I collagen
J. Biotechnol.
177
45-52
2014
Cyprinus carpio (M4VLM9), Cyprinus carpio
Ren, X.; Lamb, G.D.; Murphy, R.M.
Distribution and activation of matrix metalloproteinase-2 in skeletal muscle fibers
Am. J. Physiol. Cell Physiol.
317
C613-C625
2019
Homo sapiens (P08253), Homo sapiens, Rattus norvegicus (P33436)
Nejima, D.; Zarkouna, Y.; Pujol, P.; Gammoudi, A.; Boussen, H.; Manai, M.
Clinicopathologic and prognostic significance of gelatinase A in Tunisian colorectal cancer a case-control study
Appl. Immunohistochem. Mol. Morphol.
25
64-70
2017
Homo sapiens (P08253), Homo sapiens
Henriet, P.; Emonard, H.
Matrix metalloproteinase-2 not (just) a hero of the past
Biochimie
166
223-232
2019
Homo sapiens (P08253)
Lesniak-Walentyn, A.; Hrabia, A.
Expression and localization of matrix metalloproteinases (MMP-2, -7, -9) and their tissue inhibitors (TIMP-2, -3) in the chicken oviduct during maturation
Cell Tissue Res.
364
185-197
2016
Gallus gallus (Q90611), Gallus gallus, Gallus gallus Hy-Line Brown (Q90611)
Lian, Y.Y.; He, H.H.; Zhang, C.Z.; Li, X.C.; Chen, Y.H.
Functional characterization of a matrix metalloproteinase 2 gene in Litopenaeus vannamei
Fish Shellfish Immunol.
84
404-413
2019
Penaeus vannamei (A0A5H2QHE4), Penaeus vannamei
Nishihama, K.; Yasuma, T.; Yano, Y.; D Alessandro-Gabazza, C.N.; Toda, M.; Hinneh, J.A.; Baffour Tonto, P.; Takeshita, A.; Totoki, T.; Mifuji-Moroka, R.; Kobayashi, T.; Iwasa, M.; Takei, Y.; Morser, J.; Cann, I.; Gabazza, E.C.
Anti-apoptotic activity of human matrix metalloproteinase-2 attenuates diabetes mellitus
Metab. Clin. Exp.
82
88-99
2018
Homo sapiens (P08253), Homo sapiens
Baez, I.B.; Sampieri, C.L.; Solano, F.C.; Martinez Cazares, M.T.; Montero, H.; Cuevas, R.Z.
Activity of matrix metalloproteinase 2 and 9 isoforms in sputum samples from individuals infected with M. tuberculosis
Microb. Pathog.
135
103607
2019
Homo sapiens (P08253), Homo sapiens
Abu Bakar, A.R.; Ripen, A.M.; Merican, A.F.; Mohamad, S.B.
Enzymatic inhibitory activity of Ficus deltoidea leaf extract on matrix metalloproteinase-2, 8 and 9
Nat. Prod. Res.
33
1765-1768
2019
Homo sapiens (P08253)
Kopaliani, I.; Martin, M.; Zatschler, B.; Mueller, B.; Deussen, A.
Whey peptide isoleucine-tryptophan inhibits expression and activity of matrix metalloproteinase-2 in rat aorta
Peptides
82
52-59
2016
Rattus norvegicus (P33436)
Jana, S.; Chatterjee, K.; Ray, A.K.; DasMahapatra, P.; Swarnakar, S.
Regulation of matrix metalloproteinase-2 activity by COX-2-PGE2-pAKT axis promotes angiogenesis in endometriosis
PLoS ONE
11
e0163540
2016
Homo sapiens (P08253), Homo sapiens
Yan, L.; Jin, T.; Chen, Y.; Zhan, C.; Zhang, L.; Weng, L.; Liu, G.; Cao, M.
Characterization of a recombinant matrix metalloproteinase-2 from sea cucumber (Stichopus japonicas) and its application to prepare bioactive collagen hydrolysate
Process Biochem.
72
63-70
2018
Apostichopus japonicus (A0A2P9J4V0)
-
Nicolai, E.; Sinibaldi, F.; Sannino, G.; Lagana, G.; Basoli, F.; Licoccia, S.; Cozza, P.; Santucci, R.; Piro, M.C.
Omega-3 and omega-6 fatty acids act as inhibitors of the matrix metalloproteinase-2 and matrix metalloproteinase-9 activity
Protein J.
36
278-285
2017
Homo sapiens (P08253)
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