3.4.24.21: astacin

This is an abbreviated version!
For detailed information about astacin, go to the full flat file.

Word Map on EC 3.4.24.21

3.4.24.21

meprin

metalloproteases

pellucida

zona

tolloid

metzincins

zp2

polyspermy

zinc-endopeptidase

hydra

c-proteinase

fetuin-b

hexxh

met-turn

adamalysins

hexxhxxgxxhe

tolloid-like

3.4.24.18

n-benzoyl-l-tyrosyl-p-aminobenzoic

serralysins

metalloendoprotease

loxosceles

Reaction

Hydrolysis of peptide bonds in substrates containing five or additional information amino acids, preferentially with Ala in P1', and Pro in P2' =

Synonyms

Ace-MTP-2, Ancylostoma ceylanicum metalloprotease 2, Ast1, Ast2, Ast3, Ast4, Ast5, Ast6, Ast7, Ast9, astacin, astacin metallopeptidases, astacin metalloprotease, astacin-like metalloendopeptidase, astacin-like metalloprotease, astacin-like metalloprotease toxin 3, astacin-Like protease 3, Astacus protease, Astacus proteinase, ASTL, BMP-1, bone morphogenetic protein 1, carp nephrosin, crayfish small-molecule protease, Crayfish small-molecule proteinase, DPY-31, EC 3.4.99.6, LALP3, LAST, LAST_MAM, MEP1A, MEP1B, More, NAS-35, nas-36, nas-37, nephrosin, Ovastacin, Procollagen C-proteinase, Qcam1, Sc-AST, Smed-ast-1, Smed-ast-2, Smed-ast-3, Smed-ast-4, Smed-ast-5, Smed-ast-6, Smed-ast-7, Smed-ast-9, toxin 3, Xhe2

ECTree

3 Hydrolases

3.4 Acting on peptide bonds (peptidases)

3.4.24 Metalloendopeptidases

3.4.24.21 astacin

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Results	in table
6	Activating Compound
44	AA Sequence
1	CAS Registry Number
19	Cloned(Commentary)
13	Crystallization (Commentary)
124	Disease/ Diagnostics
47	General Information
3	General Stability
92	Inhibitors
8	Ki Value [mM]
55	KM Value [mM]
23	Localization
64	Metals/Ions
17	Molecular Weight [Da]
4	Natural Substrates/ Products (Substrates)
61	Organism
13	PDB ID
19	pH Optimum
1	pH Range
8	pH Stability
10	Posttranslational Modification
5	Protein Variants
10	Purification (Commentary)
2	Reaction
2	Reaction Type
51	Reference
51	Source Tissue
1	Specific Activity [micromol/min/mg]
1	Storage Stability
134	Substrates and Products (Substrate)
11	Subunits
92	Synonyms
16	Temperature Optimum [°C]
3	Temperature Stability [°C]
59	Turnover Number [1/s]

Substrates Products

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Substrates Products on EC 3.4.24.21 - astacin

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(Ala)n 4-nitroanilide + H2O

Astacus astacus

n: 1,2,3

31062

2-aminobenzoyl-Arg-Gly-Pro-Phe-Ser-Pro-(4-nitro)Phe-Arg + H2O

2-aminobenzoyl-Arg-Gly-Pro-Phe + Ser-Pro-(4-nitro)Phe-Arg

Astacus astacus

fluorogenic bradykinin analog substrate, cleavage site: Phe-Ser

31028

2-aminobenzoyl-Arg-Hyp-Gly-Phe-Ser-Pro-(4-nitro)Phe-Arg + H2O

2-aminobenzoyl-Arg-Hyp-Gly-Phe + Ser-Pro-(4-nitro)Phe-Arg

Astacus astacus

fluorogenic bradykinin analog substrate, cleavage site: Phe-Ser

31028

2-aminobenzoyl-Arg-Pro-Gly-Ala-Ser-Pro-(4-nitro)Phe-Arg + H2O

2-aminobenzoyl-Arg-Pro-Gly-Ala + Ser-Pro-(4-nitro)Phe-Arg

Astacus astacus

fluorogenic bradykinin analog substrate, cleavage sites: Gly-Ala and Ala-Ser

31028

major products

31028

2-aminobenzoyl-Arg-Pro-Gly-Glu-Ser-Pro-(4-nitro)Phe-Arg + H2O

2-aminobenzoyl-Arg-Pro-Gly-Glu + Ser-Pro-(4-nitro)Phe-Arg

Astacus astacus

fluorogenic bradykinin analog substrate, cleavage site: Glu-Ser

31028

2-aminobenzoyl-Arg-Pro-Gly-Leu-Ser-Pro-(4-nitro)Phe-Arg + H2O

2-aminobenzoyl-Arg-Pro-Gly-Leu + Ser-Pro-(4-nitro)Phe-Arg