3.4.24.21: astacin
This is an abbreviated version!
For detailed information about astacin, go to the full flat file.
Word Map on EC 3.4.24.21
-
3.4.24.21
-
meprin
-
metalloproteases
-
pellucida
-
zona
-
tolloid
-
metzincins
-
zp2
-
polyspermy
-
zinc-endopeptidase
-
hydra
-
c-proteinase
-
fetuin-b
-
hexxh
-
met-turn
-
adamalysins
-
hexxhxxgxxhe
-
tolloid-like
-
3.4.24.18
-
n-benzoyl-l-tyrosyl-p-aminobenzoic
-
serralysins
-
metalloendoprotease
-
loxosceles
- 3.4.24.21
- meprin
- metalloproteases
- pellucida
- zona
-
tolloid
-
metzincins
- zp2
-
polyspermy
-
zinc-endopeptidase
- hydra
-
c-proteinase
-
fetuin-b
-
hexxh
-
met-turn
- adamalysins
-
hexxhxxgxxhe
-
tolloid-like
-
3.4.24.18
-
n-benzoyl-l-tyrosyl-p-aminobenzoic
- serralysins
- metalloendoprotease
- loxosceles
Reaction
Hydrolysis of peptide bonds in substrates containing five or additional information amino acids, preferentially with Ala in P1', and Pro in P2' =
Synonyms
Ace-MTP-2, Ancylostoma ceylanicum metalloprotease 2, Ast1, Ast2, Ast3, Ast4, Ast5, Ast6, Ast7, Ast9, astacin, astacin metallopeptidases, astacin metalloprotease, astacin-like metalloendopeptidase, astacin-like metalloprotease, astacin-like metalloprotease toxin 3, astacin-Like protease 3, Astacus protease, Astacus proteinase, ASTL, BMP-1, bone morphogenetic protein 1, carp nephrosin, crayfish small-molecule protease, Crayfish small-molecule proteinase, DPY-31, EC 3.4.99.6, LALP3, LAST, LAST_MAM, MEP1A, MEP1B, More, NAS-35, nas-36, nas-37, nephrosin, Ovastacin, Procollagen C-proteinase, Qcam1, Sc-AST, Smed-ast-1, Smed-ast-2, Smed-ast-3, Smed-ast-4, Smed-ast-5, Smed-ast-6, Smed-ast-7, Smed-ast-9, toxin 3, Xhe2
ECTree
3.4.24.21 astacinAdvanced search results
results (
results (Source Tissue
Source Tissue on EC 3.4.24.21 - astacin
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
top
SOURCE TISSUE 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
SOURCE
-
the enzyme Xhe2 is exclusively expressed in hatching gland cells as they first emerge at the lateral edge of the anterior neural plate, and persists in this tissue up to the tadpole stage
astacin is synthesized as a preproenzyme in the midgut gland
-
LAST_MAM signals are detected in all investigated tissues, most dominantly in the proventriculus and muscle
-
the proenzyme is only transiently found within the ducts between the hepatopancreas and the stomach
-
LAST_MAM signals are detected in all investigated tissues, most dominantly in the proventriculus and muscle
additional information
-
synthesized in (the fibrillar cells (F-cells) of) the hepatopancreas (midgut gland) and stored extracellularly in the cardia
-
synthesized in the hepatopancreas (midgut gland) and stored extracellularly in the cardia
-
synthesized in the hepatopancreas (midgut gland) and stored extracellularly in the cardia
additional information
highest enzyme expression level occurs in the adult stage of the parasite
additional information
-
highest enzyme expression level occurs in the adult stage of the parasite
additional information
-
LAST_MAM signals are detected in all investigated tissues, most dominantly in the proventriculus and muscle
additional information
-
eight astacins with a minimal structure (a signal peptide, an activation domain and a Zn-binding catalytic domain), that are colocalized in large cells organized in a peculiar, not yet morphologically characterized, two-ring-shaped structure located in the middle of the body. A single astacin Smed-ast-8, characterized by a ShK toxin domain in its C-terminal region, has been found to be produced in gastrodermal cells. Smed-ast-1 almost completely colocalizes with Smed-ast-2, Smedast-3, Smed-ast-4, Smed-ast-5, Smed-ast-6, Smed-ast-7 and Smed-ast-9. Planarian astacins are exclusive for post-mitotic differentiated cells
additional information
eight astacins with a minimal structure (a signal peptide, an activation domain and a Zn-binding catalytic domain), that are colocalized in large cells organized in a peculiar, not yet morphologically characterized, two-ring-shaped structure located in the middle of the body. A single astacin Smed-ast-8, characterized by a ShK toxin domain in its C-terminal region, has been found to be produced in gastrodermal cells. Smed-ast-1 almost completely colocalizes with Smed-ast-2, Smedast-3, Smed-ast-4, Smed-ast-5, Smed-ast-6, Smed-ast-7 and Smed-ast-9. Planarian astacins are exclusive for post-mitotic differentiated cells
additional information
eight astacins with a minimal structure (a signal peptide, an activation domain and a Zn-binding catalytic domain), that are colocalized in large cells organized in a peculiar, not yet morphologically characterized, two-ring-shaped structure located in the middle of the body. A single astacin Smed-ast-8, characterized by a ShK toxin domain in its C-terminal region, has been found to be produced in gastrodermal cells. Smed-ast-1 almost completely colocalizes with Smed-ast-2, Smedast-3, Smed-ast-4, Smed-ast-5, Smed-ast-6, Smed-ast-7 and Smed-ast-9. Planarian astacins are exclusive for post-mitotic differentiated cells
additional information
eight astacins with a minimal structure (a signal peptide, an activation domain and a Zn-binding catalytic domain), that are colocalized in large cells organized in a peculiar, not yet morphologically characterized, two-ring-shaped structure located in the middle of the body. A single astacin Smed-ast-8, characterized by a ShK toxin domain in its C-terminal region, has been found to be produced in gastrodermal cells. Smed-ast-1 almost completely colocalizes with Smed-ast-2, Smedast-3, Smed-ast-4, Smed-ast-5, Smed-ast-6, Smed-ast-7 and Smed-ast-9. Planarian astacins are exclusive for post-mitotic differentiated cells
additional information
eight astacins with a minimal structure (a signal peptide, an activation domain and a Zn-binding catalytic domain), that are colocalized in large cells organized in a peculiar, not yet morphologically characterized, two-ring-shaped structure located in the middle of the body. A single astacin Smed-ast-8, characterized by a ShK toxin domain in its C-terminal region, has been found to be produced in gastrodermal cells. Smed-ast-1 almost completely colocalizes with Smed-ast-2, Smedast-3, Smed-ast-4, Smed-ast-5, Smed-ast-6, Smed-ast-7 and Smed-ast-9. Planarian astacins are exclusive for post-mitotic differentiated cells
additional information
eight astacins with a minimal structure (a signal peptide, an activation domain and a Zn-binding catalytic domain), that are colocalized in large cells organized in a peculiar, not yet morphologically characterized, two-ring-shaped structure located in the middle of the body. A single astacin Smed-ast-8, characterized by a ShK toxin domain in its C-terminal region, has been found to be produced in gastrodermal cells. Smed-ast-1 almost completely colocalizes with Smed-ast-2, Smedast-3, Smed-ast-4, Smed-ast-5, Smed-ast-6, Smed-ast-7 and Smed-ast-9. Planarian astacins are exclusive for post-mitotic differentiated cells
additional information
eight astacins with a minimal structure (a signal peptide, an activation domain and a Zn-binding catalytic domain), that are colocalized in large cells organized in a peculiar, not yet morphologically characterized, two-ring-shaped structure located in the middle of the body. A single astacin Smed-ast-8, characterized by a ShK toxin domain in its C-terminal region, has been found to be produced in gastrodermal cells. Smed-ast-1 almost completely colocalizes with Smed-ast-2, Smedast-3, Smed-ast-4, Smed-ast-5, Smed-ast-6, Smed-ast-7 and Smed-ast-9. Planarian astacins are exclusive for post-mitotic differentiated cells
additional information
eight astacins with a minimal structure (a signal peptide, an activation domain and a Zn-binding catalytic domain), that are colocalized in large cells organized in a peculiar, not yet morphologically characterized, two-ring-shaped structure located in the middle of the body. A single astacin Smed-ast-8, characterized by a ShK toxin domain in its C-terminal region, has been found to be produced in gastrodermal cells. Smed-ast-1 almost completely colocalizes with Smed-ast-2, Smedast-3, Smed-ast-4, Smed-ast-5, Smed-ast-6, Smed-ast-7 and Smed-ast-9. Planarian astacins are exclusive for post-mitotic differentiated cells
additional information
eight astacins with a minimal structure (a signal peptide, an activation domain and a Zn-binding catalytic domain), that are colocalized in large cells organized in a peculiar, not yet morphologically characterized, two-ring-shaped structure located in the middle of the body. A single astacin Smed-ast-8, characterized by a ShK toxin domain in its C-terminal region, has been found to be produced in gastrodermal cells. Smed-ast-1 almost completely colocalizes with Smed-ast-2, Smedast-3, Smed-ast-4, Smed-ast-5, Smed-ast-6, Smed-ast-7 and Smed-ast-9. Planarian astacins are exclusive for post-mitotic differentiated cells
additional information
developmental expression of enzyme Xhe2 and its regulation by transcription factor Pax3, overview
